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What is Lupron Depot
LeuprolideThe Generic name of this drug
Treatment SummaryLeuprolide is a synthetic hormone-like drug used to reduce the levels of sex hormones in the body. It is a version of the natural hormone gonadotropin-releasing hormone (GnRH) and works by mimicking its effects on the body. Leuprolide is used to treat advanced prostate cancer, endometriosis, and early puberty. It is available as a daily subcutaneous injection under the name Lupron™ by Abbvie Endocrine Inc. and newer versions of the drug can be injected every six months. Leuprolide is the main treatment for these conditions.
Lupronis the brand name
Lupron Depot Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Lupron
Leuprolide
1986
57
Effectiveness
How Lupron Depot Affects PatientsLeuprolide is a drug used to reduce the production of hormones like testosterone and estradiol. It is used to treat endometriosis, uterine leiomyomata, advanced prostate cancer, and central precocious puberty in children. When taking leuprolide, women should be aware of the risk of decreased bone mineral density and pregnancy complications. Men may experience flares of prostate cancer symptoms, as well as hyperglycemia, diabetes, and cardiovascular disease. In children, side effects may include convulsions and psychiatric symptoms. Patients with a history of depression should watch for recurrence of depressive symptoms.
How Lupron Depot works in the bodyLeuprolide works by activating the release of hormones from the pituitary gland. This in turn leads to an increase in sex hormones, like testosterone and estrogen. After a few weeks of use, the hormones stop being released and the effects of leuprolide are reversed.
When to interrupt dosage
The endorsed dose of Lupron Depot is contingent upon the diagnosed condition, including Anger Management Therapy, Central Precocious Puberty (CPP) and Uterine Fibroids. The dosage is dependent on the method of delivery (e.g. Intramuscular or Intramuscular; Topical) specified in the table hereunder.Condition
Dosage
Administration
Prostatic Neoplasms
, 10.0 mg/mL, 7.5 mg, 3.75 mg, 22.5 mg, 30.0 mg, 11.25 mg, 15.0 mg, 5.0 mg/mL, 72.0 mg, 3.75 mg/mL, 7.5 mg/mL, 225.0 mg/mL, 75.0 mg/mL, 15.0 mg/mL, 11.25 mg/mL, 45.0 mg/mL, 450.0 mg/mL, 300.0 mg/mL, 30.0 mg/mL, 22.5 mg/mL, 45.0 mg, 42.0 mg, 0.42 mg/mg
, Kit, Subcutaneous, Injection, solution, Injection, solution - Subcutaneous, Kit - Subcutaneous, Intramuscular, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Injection, powder, for suspension, extended release - Subcutaneous, Liquid, Liquid - Subcutaneous, Injection, powder, for suspension, extended release; Kit, Injection, powder, for suspension, extended release; Kit - Intramuscular, Solution, Solution - Subcutaneous, Injection, powder, lyophilized, for suspension, Injection, powder, lyophilized, for suspension - Intramuscular, Intramuscular; Topical, Kit - Intramuscular; Topical, Intramuscular; Oral; Topical, Subcutaneous; Topical, Kit - Subcutaneous; Topical, Kit - Intramuscular, Injection, emulsion, Injection, emulsion - Subcutaneous
Puberty, Precocious
, 10.0 mg/mL, 7.5 mg, 3.75 mg, 22.5 mg, 30.0 mg, 11.25 mg, 15.0 mg, 5.0 mg/mL, 72.0 mg, 3.75 mg/mL, 7.5 mg/mL, 225.0 mg/mL, 75.0 mg/mL, 15.0 mg/mL, 11.25 mg/mL, 45.0 mg/mL, 450.0 mg/mL, 300.0 mg/mL, 30.0 mg/mL, 22.5 mg/mL, 45.0 mg, 42.0 mg, 0.42 mg/mg
, Kit, Subcutaneous, Injection, solution, Injection, solution - Subcutaneous, Kit - Subcutaneous, Intramuscular, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Injection, powder, for suspension, extended release - Subcutaneous, Liquid, Liquid - Subcutaneous, Injection, powder, for suspension, extended release; Kit, Injection, powder, for suspension, extended release; Kit - Intramuscular, Solution, Solution - Subcutaneous, Injection, powder, lyophilized, for suspension, Injection, powder, lyophilized, for suspension - Intramuscular, Intramuscular; Topical, Kit - Intramuscular; Topical, Intramuscular; Oral; Topical, Subcutaneous; Topical, Kit - Subcutaneous; Topical, Kit - Intramuscular, Injection, emulsion, Injection, emulsion - Subcutaneous
Uterine Fibroids
, 10.0 mg/mL, 7.5 mg, 3.75 mg, 22.5 mg, 30.0 mg, 11.25 mg, 15.0 mg, 5.0 mg/mL, 72.0 mg, 3.75 mg/mL, 7.5 mg/mL, 225.0 mg/mL, 75.0 mg/mL, 15.0 mg/mL, 11.25 mg/mL, 45.0 mg/mL, 450.0 mg/mL, 300.0 mg/mL, 30.0 mg/mL, 22.5 mg/mL, 45.0 mg, 42.0 mg, 0.42 mg/mg
, Kit, Subcutaneous, Injection, solution, Injection, solution - Subcutaneous, Kit - Subcutaneous, Intramuscular, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Injection, powder, for suspension, extended release - Subcutaneous, Liquid, Liquid - Subcutaneous, Injection, powder, for suspension, extended release; Kit, Injection, powder, for suspension, extended release; Kit - Intramuscular, Solution, Solution - Subcutaneous, Injection, powder, lyophilized, for suspension, Injection, powder, lyophilized, for suspension - Intramuscular, Intramuscular; Topical, Kit - Intramuscular; Topical, Intramuscular; Oral; Topical, Subcutaneous; Topical, Kit - Subcutaneous; Topical, Kit - Intramuscular, Injection, emulsion, Injection, emulsion - Subcutaneous
Endometriosis
, 10.0 mg/mL, 7.5 mg, 3.75 mg, 22.5 mg, 30.0 mg, 11.25 mg, 15.0 mg, 5.0 mg/mL, 72.0 mg, 3.75 mg/mL, 7.5 mg/mL, 225.0 mg/mL, 75.0 mg/mL, 15.0 mg/mL, 11.25 mg/mL, 45.0 mg/mL, 450.0 mg/mL, 300.0 mg/mL, 30.0 mg/mL, 22.5 mg/mL, 45.0 mg, 42.0 mg, 0.42 mg/mg
, Kit, Subcutaneous, Injection, solution, Injection, solution - Subcutaneous, Kit - Subcutaneous, Intramuscular, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Injection, powder, for suspension, extended release - Subcutaneous, Liquid, Liquid - Subcutaneous, Injection, powder, for suspension, extended release; Kit, Injection, powder, for suspension, extended release; Kit - Intramuscular, Solution, Solution - Subcutaneous, Injection, powder, lyophilized, for suspension, Injection, powder, lyophilized, for suspension - Intramuscular, Intramuscular; Topical, Kit - Intramuscular; Topical, Intramuscular; Oral; Topical, Subcutaneous; Topical, Kit - Subcutaneous; Topical, Kit - Intramuscular, Injection, emulsion, Injection, emulsion - Subcutaneous
confirmed by clinical features
, 10.0 mg/mL, 7.5 mg, 3.75 mg, 22.5 mg, 30.0 mg, 11.25 mg, 15.0 mg, 5.0 mg/mL, 72.0 mg, 3.75 mg/mL, 7.5 mg/mL, 225.0 mg/mL, 75.0 mg/mL, 15.0 mg/mL, 11.25 mg/mL, 45.0 mg/mL, 450.0 mg/mL, 300.0 mg/mL, 30.0 mg/mL, 22.5 mg/mL, 45.0 mg, 42.0 mg, 0.42 mg/mg
, Kit, Subcutaneous, Injection, solution, Injection, solution - Subcutaneous, Kit - Subcutaneous, Intramuscular, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Injection, powder, for suspension, extended release - Subcutaneous, Liquid, Liquid - Subcutaneous, Injection, powder, for suspension, extended release; Kit, Injection, powder, for suspension, extended release; Kit - Intramuscular, Solution, Solution - Subcutaneous, Injection, powder, lyophilized, for suspension, Injection, powder, lyophilized, for suspension - Intramuscular, Intramuscular; Topical, Kit - Intramuscular; Topical, Intramuscular; Oral; Topical, Subcutaneous; Topical, Kit - Subcutaneous; Topical, Kit - Intramuscular, Injection, emulsion, Injection, emulsion - Subcutaneous
symptom recurrence
, 10.0 mg/mL, 7.5 mg, 3.75 mg, 22.5 mg, 30.0 mg, 11.25 mg, 15.0 mg, 5.0 mg/mL, 72.0 mg, 3.75 mg/mL, 7.5 mg/mL, 225.0 mg/mL, 75.0 mg/mL, 15.0 mg/mL, 11.25 mg/mL, 45.0 mg/mL, 450.0 mg/mL, 300.0 mg/mL, 30.0 mg/mL, 22.5 mg/mL, 45.0 mg, 42.0 mg, 0.42 mg/mg
, Kit, Subcutaneous, Injection, solution, Injection, solution - Subcutaneous, Kit - Subcutaneous, Intramuscular, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Injection, powder, for suspension, extended release - Subcutaneous, Liquid, Liquid - Subcutaneous, Injection, powder, for suspension, extended release; Kit, Injection, powder, for suspension, extended release; Kit - Intramuscular, Solution, Solution - Subcutaneous, Injection, powder, lyophilized, for suspension, Injection, powder, lyophilized, for suspension - Intramuscular, Intramuscular; Topical, Kit - Intramuscular; Topical, Intramuscular; Oral; Topical, Subcutaneous; Topical, Kit - Subcutaneous; Topical, Kit - Intramuscular, Injection, emulsion, Injection, emulsion - Subcutaneous
Palliative Treatment
, 10.0 mg/mL, 7.5 mg, 3.75 mg, 22.5 mg, 30.0 mg, 11.25 mg, 15.0 mg, 5.0 mg/mL, 72.0 mg, 3.75 mg/mL, 7.5 mg/mL, 225.0 mg/mL, 75.0 mg/mL, 15.0 mg/mL, 11.25 mg/mL, 45.0 mg/mL, 450.0 mg/mL, 300.0 mg/mL, 30.0 mg/mL, 22.5 mg/mL, 45.0 mg, 42.0 mg, 0.42 mg/mg
, Kit, Subcutaneous, Injection, solution, Injection, solution - Subcutaneous, Kit - Subcutaneous, Intramuscular, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Injection, powder, for suspension, extended release - Subcutaneous, Liquid, Liquid - Subcutaneous, Injection, powder, for suspension, extended release; Kit, Injection, powder, for suspension, extended release; Kit - Intramuscular, Solution, Solution - Subcutaneous, Injection, powder, lyophilized, for suspension, Injection, powder, lyophilized, for suspension - Intramuscular, Intramuscular; Topical, Kit - Intramuscular; Topical, Intramuscular; Oral; Topical, Subcutaneous; Topical, Kit - Subcutaneous; Topical, Kit - Intramuscular, Injection, emulsion, Injection, emulsion - Subcutaneous
Iron Deficiency Anemia
, 10.0 mg/mL, 7.5 mg, 3.75 mg, 22.5 mg, 30.0 mg, 11.25 mg, 15.0 mg, 5.0 mg/mL, 72.0 mg, 3.75 mg/mL, 7.5 mg/mL, 225.0 mg/mL, 75.0 mg/mL, 15.0 mg/mL, 11.25 mg/mL, 45.0 mg/mL, 450.0 mg/mL, 300.0 mg/mL, 30.0 mg/mL, 22.5 mg/mL, 45.0 mg, 42.0 mg, 0.42 mg/mg
, Kit, Subcutaneous, Injection, solution, Injection, solution - Subcutaneous, Kit - Subcutaneous, Intramuscular, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Injection, powder, for suspension, extended release - Subcutaneous, Liquid, Liquid - Subcutaneous, Injection, powder, for suspension, extended release; Kit, Injection, powder, for suspension, extended release; Kit - Intramuscular, Solution, Solution - Subcutaneous, Injection, powder, lyophilized, for suspension, Injection, powder, lyophilized, for suspension - Intramuscular, Intramuscular; Topical, Kit - Intramuscular; Topical, Intramuscular; Oral; Topical, Subcutaneous; Topical, Kit - Subcutaneous; Topical, Kit - Intramuscular, Injection, emulsion, Injection, emulsion - Subcutaneous
Iron replacement therapy
, 10.0 mg/mL, 7.5 mg, 3.75 mg, 22.5 mg, 30.0 mg, 11.25 mg, 15.0 mg, 5.0 mg/mL, 72.0 mg, 3.75 mg/mL, 7.5 mg/mL, 225.0 mg/mL, 75.0 mg/mL, 15.0 mg/mL, 11.25 mg/mL, 45.0 mg/mL, 450.0 mg/mL, 300.0 mg/mL, 30.0 mg/mL, 22.5 mg/mL, 45.0 mg, 42.0 mg, 0.42 mg/mg
, Kit, Subcutaneous, Injection, solution, Injection, solution - Subcutaneous, Kit - Subcutaneous, Intramuscular, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Injection, powder, for suspension, extended release - Subcutaneous, Liquid, Liquid - Subcutaneous, Injection, powder, for suspension, extended release; Kit, Injection, powder, for suspension, extended release; Kit - Intramuscular, Solution, Solution - Subcutaneous, Injection, powder, lyophilized, for suspension, Injection, powder, lyophilized, for suspension - Intramuscular, Intramuscular; Topical, Kit - Intramuscular; Topical, Intramuscular; Oral; Topical, Subcutaneous; Topical, Kit - Subcutaneous; Topical, Kit - Intramuscular, Injection, emulsion, Injection, emulsion - Subcutaneous
Warnings
Lupron Depot ContraindicationsCondition
Risk Level
Notes
Vaginal Hemorrhage
Do Not Combine
Pregnant Women
Do Not Combine
Metrorrhagia
Do Not Combine
Breast Neoplasms
Do Not Combine
Liver Neoplasms
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Leuprolide may interact with Pulse Frequency
Common Lupron Depot Drug Interactions
Drug Name
Risk Level
Description
Amiodarone
Major
The risk or severity of QTc prolongation can be increased when Leuprolide is combined with Amiodarone.
Anagrelide
Major
The risk or severity of QTc prolongation can be increased when Leuprolide is combined with Anagrelide.
Arsenic trioxide
Major
The risk or severity of QTc prolongation can be increased when Leuprolide is combined with Arsenic trioxide.
Artemether
Major
The risk or severity of QTc prolongation can be increased when Leuprolide is combined with Artemether.
Asenapine
Major
The risk or severity of QTc prolongation can be increased when Leuprolide is combined with Asenapine.
Lupron Depot Toxicity & Overdose RiskLeuprolide has been found to be very safe, with minimal side effects. Even when taken at high doses of up to 20mg per day for two years, prostate cancer patients did not experience any additional adverse effects compared to those taking a much lower dose of 1mg per day.
Lupron Depot Novel Uses: Which Conditions Have a Clinical Trial Featuring Lupron Depot?
144 active trials are currently in progress to assess the efficacy of Lupron Depot for alleviating symptom recurrence, Uterine Fibroids and Iron Deficiency Anemia.Condition
Clinical Trials
Trial Phases
symptom recurrence
0 Actively Recruiting
Puberty, Precocious
1 Actively Recruiting
Phase 3
Endometriosis
29 Actively Recruiting
Early Phase 1, Phase 2, Phase 3, Not Applicable, Phase 4
Iron Deficiency Anemia
19 Actively Recruiting
Phase 3, Phase 2, Phase 1, Not Applicable, Phase 4
Prostatic Neoplasms
0 Actively Recruiting
confirmed by clinical features
0 Actively Recruiting
Palliative Treatment
1 Actively Recruiting
Not Applicable
Iron replacement therapy
0 Actively Recruiting
Uterine Fibroids
7 Actively Recruiting
Phase 2, Early Phase 1, Phase 3, Not Applicable, Phase 4
Lupron Depot Reviews: What are patients saying about Lupron Depot?
4.7Patient Review
7/10/2021 The 3-month lupron injection was a success in my case. It brought my testosterone level from 840 to 11 within three weeks! However, there are side effects that come with it, including: 1) lack of sexual desire and performance; 2) hot flashes; 3) fatigue; and 4) low red blood cell count (anemia). Despite all this, the drug is still effective in fighting prostate cancer.
4.7Patient Review
7/10/2021 The 3 month lupron injection was very effective in lowering my testosterone levels. However, it did come with some nasty side-effects like hot flashes and fatigue.
4.7Patient Review
7/10/2021 Lupron is a pretty effective drug, but it's not without its drawbacks. I experienced decreased sexual desire and performance, hot flashes, fatigue, and low red blood cell count (anemia). So while it was successful in treating my prostate cancer, it wasn't exactly a fun experience.
4.3Patient Review
7/5/2022 I've been on Lupron for three years now, taking it every three months to keep my prostate cancer at bay. It does lower my PSA and testosterone levels as well as slowing the cancer's growth, but the side effects are pretty harsh. I get hot flashes all day long, every day, and they range in intensity. They make it impossible to get a good night's sleep, which is really tough. I haven't found any medication that helps much with them; it's just something I have to deal with.
4.3Patient Review
7/5/2022 Lupron is effective at its job, but the side effects are harsh. I get hot flashes constantly throughout the day and they make it impossible to get a good night's sleep. I haven't found any medication that really helps with this symptom.
4.3Patient Review
7/5/2022 Lupron is an effective treatment for reacurring prostate cancer, slowing the growth of the cancer and lowering PSA levels. However, the side effects can be difficult to deal with. I suffer from constant hot flashes which make it impossible to get a good night's sleep. I haven't found any medication that helps much with this side effect, so it's a trade-off between dealing with the cancer and dealing with the side effects.
3.7Patient Review
1/14/2014 My blood pressure increased while taking this medication, and there were some side effects that weren't explained to me ahead of time. All things considered, I would still take it again if given the choice.
3.7Patient Review
1/14/2014 Overall, this treatment did help me. However, my blood pressure increased while taking it and I experienced some side effects that were not explained to me beforehand.
3.7Patient Review
1/14/2014 Although my blood pressure went up and I experienced some unexpected side effects, I would still choose to take this medication again.
3Patient Review
3/6/2014 I've been using this treatment for a month now, and it's helped me a lot.
3Patient Review
3/6/2014 I've been using this treatment for about a month now.
3Patient Review
3/6/2014 I tried this treatment for a month and saw some results.
2.3Patient Review
3/19/2014 I've been on this medication for 15 months, and it has helped me during my radiation treatments for prostate cancer. However, the side effects have been very challenging to deal with. These include: continual fatigue, hot flashes/sweats, memory challenges, swollen calves/feet, swollen hands, joint pain/aches in legs & hands, body hair loss, numbing down right arm & hand. Zero libido. Mild pain sensations over lower body mostly during sleep time. Restless sleep, therefore fatigue during daytime.
2.3Patient Review
3/19/2014 I've been on this medication for 15 months, and it's been a real challenge. The side effects are never-ending fatigue, hot flashes and sweats, memory problems, swollen calves and feet, swollen hands, joint pain in legs and hands, body hair loss, numbness in right arm and hand, zero libido. While the benefits have been good, the side effects are really tough to deal with.
2.3Patient Review
3/19/2014 I've been on this medication for 15 months now, and it has helped me through my prostate cancer radiation treatments. However, the side effects have been very difficult to deal with. I'm constantly tired, hot flashes/sweats, memory challenges, swollen calves/feet, swollen hands, joint pain/aches in legs & hands, body hair loss, numbing down right arm & hand. Zero libido. Mild pain sensations over lower body mostly during sleep time. Restless sleep, therefore fatigue during daytime.
1Patient Review
3/21/2014 My daughter started taking this medication when she was seven years old. Within a year, she had gained 30 pounds, grown two inches, gone up three shoe sizes, developed acne, and experienced severe depression and anti-social behavior at school. The side effects of this medication are not worth the benefits.
1Patient Review
3/21/2014 My daughter started this medication at the age of 7 yearsold. She was 5-2", wore a size 7 shoe, and 125 lbs. 1year later months later, she has severe depression, anti-social behavior at school, sleep walks and has full conversations in her sleep, lethargic and we have to force her to play sports, she has gained 30 lbs in a year even though she is consisently in the gym and non-stop sports (by force), grown 2 inches, 3 shoe sizes and has full acne. The side effects are really bad compared to any potential benefits.
1Patient Review
3/21/2014 We started our daughter on this medication when she was seven years old. She was five-two", wore a size seven shoe, and weighed 125 pounds. One year later, she developed severe depression, anti-social behavior at school, sleep walking, and conversations in her sleep. Additionally, she became lethargic and we had to force her to play sports. In the span of one year, she gained 30 pounds despite being constantly active, grew two inches, and went up three shoe sizes. The side effects of this medication are not worth it.
Patient Q&A Section about lupron depot
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What does depot Lupron do?
"The drug Lupron Depot is used to manage endometriosis, alleviating pain and reducing the presence of endometriotic lesions."
Answered by AI
Is Lupron Depot a chemo drug?
"Lupron is a chemo agent that is used to decrease the amount of certain hormones in the body to treat the symptoms associated with prostate cancer."
Answered by AI
Where is depot Lupron injected?
"Lupron Depot is a medication that is injected into a muscle once a month, or every three, four, or six months for the treatment of prostate cancer. Depot formulations are designed to release medication into the body over a certain period of time."
Answered by AI
What are the long term side effects of Lupron Depot?
"A tumor flare with prostate cancer may cause your endometriosis symptoms to worsen before they improve. High blood sugar levels may lead to type 2 diabetes. Taking Lupron Depot for a long period of time may cause a loss of bone density."
Answered by AI