Smartwatch-Guided DOAC Therapy for Atrial Fibrillation
(REACT-AF Trial)
Trial Summary
What is the purpose of this trial?
This trial tests whether taking blood-thinning medication continuously or only when a smart watch detects an irregular heartbeat is better for adults with a history of irregular heartbeats and moderate stroke risk.
Will I have to stop taking my current medications?
Participants must be willing to stop taking their current Direct Oral Anticoagulant (DOAC) medication for the study. If you are on other medications like aspirin or NSAIDs, you may need to stop them if they are not within current medical guidelines.
What data supports the effectiveness of the drug Apixaban for atrial fibrillation?
Is Apixaban (Eliquis) generally safe for humans?
What makes the AFSW Guided DOAC therapy unique for atrial fibrillation?
The AFSW Guided DOAC therapy is unique because it uses a smartwatch to guide the administration of direct-acting oral anticoagulants (DOACs) like Apixaban, which helps in preventing strokes in patients with atrial fibrillation. This approach may offer a more personalized and continuous monitoring method compared to traditional DOAC therapy, potentially improving adherence and outcomes.1391011
Research Team
Rod Passman
Principal Investigator
Northwestern University
Dan Hanley
Principal Investigator
Johns Hopkins University
Eligibility Criteria
This trial is for adults aged 22-85 with a history of Atrial Fibrillation (AF) and low-to-moderate stroke risk, who can use a smartwatch and smartphone. They must be on DOAC therapy but willing to stop if needed, not at high risk for non-cardioembolic stroke, without severe heart conditions or other health issues that increase bleeding risks.Inclusion Criteria
Exclusion Criteria
Trial Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants are randomized to either AFSW-guided, time-delimited DOAC therapy or continuous DOAC therapy
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- AFSW Guided DOAC (Device)
- Continuous DOAC therapy (Anticoagulant)
Find a Clinic Near You
Who Is Running the Clinical Trial?
Johns Hopkins University
Lead Sponsor
Theodore DeWeese
Johns Hopkins University
Chief Executive Officer since 2023
MD from an unspecified institution
Allen Kachalia
Johns Hopkins University
Chief Medical Officer since 2023
MD from an unspecified institution
National Heart, Lung, and Blood Institute (NHLBI)
Collaborator
Dr. Gary H. Gibbons
National Heart, Lung, and Blood Institute (NHLBI)
Chief Executive Officer since 2012
MD from Harvard Medical School
Dr. James P. Kiley
National Heart, Lung, and Blood Institute (NHLBI)
Chief Medical Officer since 2011
MD from University of California, San Francisco