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What is Norgestimate And Ethinyl Estradiol
NorgestimateThe Generic name of this drug
Treatment SummaryEthinylestradiol is a synthetic form of the female hormone estrogen used in many oral contraceptive pills. It was first developed in 1938 by Hans Herloff Inhoffen and Walter Hohlweg at Schering, and was approved by the FDA in 1943. It is more effective than other forms of estrogen due to its higher oral bioavailability, meaning that it can be taken in pill form instead of being injected.
Ortho Tri Cyclenis the brand name
Norgestimate And Ethinyl Estradiol Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Ortho Tri Cyclen
Norgestimate
1989
113
Approved as Treatment by the FDA
Norgestimate, commonly known as Ortho Tri Cyclen, is approved by the FDA for 8 uses which include Oral Contraceptives and Osteoporosis, Postmenopausal .Oral Contraceptives
Used to treat Oral Contraceptives in combination with Ethinylestradiol
Osteoporosis, Postmenopausal
Used to treat Postmenopausal Osteoporosis in combination with Estradiol
Acne Vulgaris
Used to treat moderate Acne vulgaris in combination with Ethinylestradiol
moderate Vulvovaginal atrophy
Used to treat moderate Vulvovaginal atrophy in combination with Estradiol
Hot flashes
Used to treat Menopause in combination with Estradiol
moderate Menopausal Vasomotor Symptoms
Used to treat moderate Menopausal Vasomotor Symptoms in combination with Estradiol
Menopause
Used to treat severe Vasomotor Symptoms Associated With Menopause in combination with Estradiol
severe menopausal vulvovaginal atrophy
Used to treat severe menopausal vulvovaginal atrophy in combination with Estradiol
Effectiveness
How Norgestimate And Ethinyl Estradiol Affects PatientsEthinylestradiol is a man-made form of estrogen that is taken once daily. It works by reducing the hormones that cause ovulation and endometrial vascularization. It is considered to be a safe drug, but there is a risk of blood clots associated with it, so individuals taking it should be aware of the potential risks.
How Norgestimate And Ethinyl Estradiol works in the bodyEthinylestradiol is a synthetic form of the hormone estrogen. It works by preventing ovulation and making it harder for sperm to reach the uterus. It also reduces luteinizing hormone and increases sex hormone binding globulin, which reduces the amount of estrogen in the body. This can lead to decreased bone density.
When to interrupt dosage
The advocated measure of Norgestimate and Ethinyl Estradiol is contingent upon the diagnosed condition, such as Acne Vulgaris, Hormonal Contraception and Folate supplementation therapy. The quantity of dosage fluctuates, in accordance with the technique of delivery indicated in the accompanying table.Condition
Dosage
Administration
Polycystic Ovarian Syndrome
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
, Kit, Oral, Tablet, Tablet - Oral, Kit - Oral
moderate Vulvovaginal atrophy
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
, Kit, Oral, Tablet, Tablet - Oral, Kit - Oral
Menopause
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
, Kit, Oral, Tablet, Tablet - Oral, Kit - Oral
severe menopausal vulvovaginal atrophy
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
, Kit, Oral, Tablet, Tablet - Oral, Kit - Oral
Osteoporosis, Postmenopausal
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
, Kit, Oral, Tablet, Tablet - Oral, Kit - Oral
Oral Contraceptives
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
, Kit, Oral, Tablet, Tablet - Oral, Kit - Oral
Menorrhagia
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
, Kit, Oral, Tablet, Tablet - Oral, Kit - Oral
Hirsutism
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
, Kit, Oral, Tablet, Tablet - Oral, Kit - Oral
moderate Menopausal Vasomotor Symptoms
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
, Kit, Oral, Tablet, Tablet - Oral, Kit - Oral
Hot flashes
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
, Kit, Oral, Tablet, Tablet - Oral, Kit - Oral
Acne Vulgaris
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
, Kit, Oral, Tablet, Tablet - Oral, Kit - Oral
Dysmenorrhea
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
, Kit, Oral, Tablet, Tablet - Oral, Kit - Oral
Warnings
Norgestimate And Ethinyl Estradiol ContraindicationsCondition
Risk Level
Notes
Breast
Do Not Combine
Breast Cancer
Do Not Combine
high risk of arterial thrombotic disease
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Hypersensitivity
Do Not Combine
Venous Thrombosis
Do Not Combine
Pulse Frequency
Do Not Combine
estrogen-sensitive cancer
Do Not Combine
Metrorrhagia
Do Not Combine
Liver Neoplasms
Do Not Combine
Common Norgestimate And Ethinyl Estradiol Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The serum concentration of Abemaciclib can be increased when it is combined with Norgestimate.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be increased when combined with Norgestimate.
Alectinib
Major
The metabolism of Alectinib can be increased when combined with Norgestimate.
Aminophylline
Major
The metabolism of Aminophylline can be increased when combined with Norgestimate.
Astemizole
Major
The metabolism of Astemizole can be increased when combined with Norgestimate.
Norgestimate And Ethinyl Estradiol Toxicity & Overdose RiskWomen who overdose on this medication may suffer from bleeding, nausea, vomiting, breast pain, abdominal pain, drowsiness, and fatigue. Treatment should include supportive care such as monitoring for potassium and sodium levels, as well as signs of metabolic acidosis.
Norgestimate And Ethinyl Estradiol Novel Uses: Which Conditions Have a Clinical Trial Featuring Norgestimate And Ethinyl Estradiol?
38 active clinical studies are exploring the potential of Norgestimate and Ethinyl Estradiol in providing Folate supplementation therapy, relieving Premenstrual Dysphoric Disorder and treating Menopause.Condition
Clinical Trials
Trial Phases
Dysmenorrhea
0 Actively Recruiting
Acne Vulgaris
0 Actively Recruiting
Osteoporosis, Postmenopausal
0 Actively Recruiting
Oral Contraceptives
1 Actively Recruiting
Not Applicable
Menopause
0 Actively Recruiting
Polycystic Ovarian Syndrome
7 Actively Recruiting
Not Applicable, Early Phase 1, Phase 1
moderate Menopausal Vasomotor Symptoms
0 Actively Recruiting
Hirsutism
0 Actively Recruiting
Hot flashes
14 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Early Phase 1, Phase 4
moderate Vulvovaginal atrophy
0 Actively Recruiting
Menorrhagia
0 Actively Recruiting
severe menopausal vulvovaginal atrophy
0 Actively Recruiting
Norgestimate And Ethinyl Estradiol Reviews: What are patients saying about Norgestimate And Ethinyl Estradiol?
5Patient Review
7/12/2016 I'm really happy with this birth control. I started using it when I was 23 and had never dealt with acne before, but then I suddenly got it really bad. After just five months of use, my face cleared up and has stayed that way ever since.
5Patient Review
4/6/2017 I had extremely negative experiences with my last birth control pill in terms of mental health, so I was really relieved to find that this one didn't have the same issue! It's also been great in clearing up my acne and making my periods shorter. The only downside is that I experienced some spotting when I first started taking them, but that's par for the course with any BC pill. All things considered, I'm very happy with this form of contraception.
5Patient Review
12/4/2016 It took me a long time to find the right birth control, but this one has really worked well for me. I would urge other women who are struggling to find something that works for them to keep trying different options and not give up hope.
5Patient Review
2/24/2022 I have found that this treatment provides me with energy and no negative side effects like headaches or cramps.
4.3Patient Review
3/8/2018 I've been using this birth control for a little over a year and it's been effective. However, one downside is that it's caused me to break out on my face occasionally and also has resulted in melasma.
3.7Patient Review
1/24/2018 I had such bad cystic acne after Nexplanon that my doctor recommended I try Starylla. Unfortunately, this didn't work out too well for me. After just two days of taking the pills (as directed, before bed), I woke up in the middle of the night with nausea and ended up vomiting both nights. I also had a headache and felt dizzy all day long.
2.7Patient Review
3/17/2021 I started using this treatment last month and have had really heavy periods with bad cramps. It's like I'm not even on birth control! I'll try for the next two months and see if there are any changes, but I'm worried about the possible side effect of blood clots.
2Patient Review
5/3/2016 It's been three months and I've been taking BC to treat my PMS symptoms. The first month was really tough with nausea and vomiting, but that has passed. Now I'm just dealing with some weight gain, acne, and bleeding between periods. I'm hoping everything will be alright after the third month.
2Patient Review
6/4/2017 I started taking this medication a few months ago and have already experienced some bad side effects. For example, I've had a continuous period for three weeks now, with no break in between cycles. Additionally, I often feel nauseous and have been getting blurred vision and migraines more frequently. I never had such problems when taking Ortho Tri Cyclen.
1.7Patient Review
1/22/2019 I started this medication in order to help with my periods and cysts, but it's only made things worse. I've been moody, crying, vomiting, and in the second month of taking it I started a period that hasn't gone away yet. And on top of all that, I had a yeast infection the first month. They say you should give it three months to work, but I'm already miserable.
1.7Patient Review
12/3/2018 I am a healthy 25 year old and began taking the pill again after giving my body a break from birth control. I am experiencing extremely bad mood swings very often and crying more than I ever have before. This definitely is not like me and I am going to stop taking this immediately.
Patient Q&A Section about norgestimate and ethinyl estradiol
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is norgestimate and ethinyl estradiol a good birth control?
"Norgestimate and ethinyl estradiol birth control pills have a high success rate of over 99 percent when used correctly, and are still 91 percent effective in everyday use."
Answered by AI
What is the side effects of norgestimate ethinyl estradiol?
"The following side effects may occur: nausea, vomiting, headache, bloating, breast tenderness, swelling of ankles/feet (fluid retention), or weight change. Spotting (vaginal bleeding between periods) or missed/irregular periods may occur, especially during the first few months of use."
Answered by AI
Do you get a period on norgestimate?
"As your body adjusts to this method of contraception, the bleeding should become less and eventually stop. If breakthrough bleeding continues off-and-on for more than 1 week or occurs after your period, call your healthcare professional.
When you first start using this contraception method, you may experience vaginal bleeding of various amounts between your regular menstrual periods. This is sometimes called spotting when it is light, or breakthrough bleeding when it is heavier. If this should occur, continue with your regular dosing schedule. As your body adjusts to this method of contraception, the bleeding should become less and eventually stop. If breakthrough bleeding continues off-and-on for more than 1 week or occurs after your period, call your healthcare professional."
Answered by AI