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What is Phospholine Iodide
EchothiophateThe Generic name of this drug
Treatment SummaryEchothiophate iodine is a medication used to treat glaucoma and occasionally used to treat a type of crossed eyes. It is a long-lasting drug that works by reducing the pressure in the eye.
Phospholine Iodide Ophthalmicis the brand name
Phospholine Iodide Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Phospholine Iodide Ophthalmic
Echothiophate
1959
7
Approved as Treatment by the FDA
Echothiophate, also called Phospholine Iodide Ophthalmic, is approved by the FDA for 4 uses including Accommodative component in esotropia and nonuveitic secondary glaucoma .Accommodative component in esotropia
Helps manage Accommodative component in esotropia
nonuveitic secondary glaucoma
Helps manage nonuveitic secondary glaucoma
Open Angle Glaucoma
Helps manage Open Angle Glaucoma (OAG)
Glaucoma, Angle-Closure
Helps manage Chronic Angle Closure Glaucoma
Effectiveness
How Phospholine Iodide Affects PatientsEchothiophate Iodide is a powerful medication used to treat glaucoma. It works by blocking the enzyme responsible for breaking down a certain chemical in the body, leading to long-term effects. After a few weeks of using eyedrops containing this drug, most patients will have lower levels of the enzyme in their blood and red blood cells.
How Phospholine Iodide works in the bodyEchothiophate Iodide is a medication that boosts the effects of acetylcholine in the eye. It works by binding to cholinesterase, an enzyme that breaks down acetylcholine. This binding is permanent and lasts for a long time, causing miosis (constriction of the pupil), improved drainage of the eye's fluid, lower eye pressure, and better focusing of the eye.
When to interrupt dosage
The prescribed amount of Phospholine Iodide is subject to the diagnosed condition, including Open Angle Glaucoma, nonuveitic secondary glaucoma and Accommodative component in esotropia. Dosage fluctuates as per the procedure of delivery (e.g. Kit or Solution) featured in the table beneath.Condition
Dosage
Administration
nonuveitic secondary glaucoma
, 1.25 mg/mL, 0.6 mg/mL, 2.5 mg/mL, 0.3 mg/mL, 6.25 mg/mL, 3.0 mg/mL, 1.5 mg/mL, 12.5 mg/mL
, Powder, for solution, Ophthalmic, Powder, for solution - Ophthalmic, Liquid; Powder, for solution, Liquid; Powder, for solution - Ophthalmic, Solution, Solution - Ophthalmic, Kit, Kit - Ophthalmic
Glaucoma, Angle-Closure
, 1.25 mg/mL, 0.6 mg/mL, 2.5 mg/mL, 0.3 mg/mL, 6.25 mg/mL, 3.0 mg/mL, 1.5 mg/mL, 12.5 mg/mL
, Powder, for solution, Ophthalmic, Powder, for solution - Ophthalmic, Liquid; Powder, for solution, Liquid; Powder, for solution - Ophthalmic, Solution, Solution - Ophthalmic, Kit, Kit - Ophthalmic
Open Angle Glaucoma
, 1.25 mg/mL, 0.6 mg/mL, 2.5 mg/mL, 0.3 mg/mL, 6.25 mg/mL, 3.0 mg/mL, 1.5 mg/mL, 12.5 mg/mL
, Powder, for solution, Ophthalmic, Powder, for solution - Ophthalmic, Liquid; Powder, for solution, Liquid; Powder, for solution - Ophthalmic, Solution, Solution - Ophthalmic, Kit, Kit - Ophthalmic
Accommodative component in esotropia
, 1.25 mg/mL, 0.6 mg/mL, 2.5 mg/mL, 0.3 mg/mL, 6.25 mg/mL, 3.0 mg/mL, 1.5 mg/mL, 12.5 mg/mL
, Powder, for solution, Ophthalmic, Powder, for solution - Ophthalmic, Liquid; Powder, for solution, Liquid; Powder, for solution - Ophthalmic, Solution, Solution - Ophthalmic, Kit, Kit - Ophthalmic
Warnings
Phospholine Iodide has two prohibitions. It should not be incorporated with the situations outlined in the following table.Phospholine Iodide ContraindicationsCondition
Risk Level
Notes
Inflammation
Do Not Combine
Angle-Closure Glaucoma
Do Not Combine
Common Phospholine Iodide Drug Interactions
Drug Name
Risk Level
Description
Hydroxyzine
Major
The risk or severity of QTc prolongation can be increased when Echothiophate is combined with Hydroxyzine.
Ziprasidone
Major
The risk or severity of QTc prolongation can be increased when Echothiophate is combined with Ziprasidone.
Fexinidazole
Moderate
The risk or severity of adverse effects can be increased when Echothiophate is combined with Fexinidazole.
Haloperidol
Moderate
The risk or severity of QTc prolongation can be increased when Echothiophate is combined with Haloperidol.
Pitolisant
Moderate
Echothiophate may increase the QTc-prolonging activities of Pitolisant.
Phospholine Iodide Toxicity & Overdose RiskSide effects of taking too much of this drug include blurry or changed vision and eye pain. The lowest toxic dose in rats is 174 micrograms per kilogram of body weight.
Phospholine Iodide Novel Uses: Which Conditions Have a Clinical Trial Featuring Phospholine Iodide?
14 active clinical trials are assessing the potential of Phospholine Iodide to alleviate Accommodative component in esotropia, Open Angle Glaucoma and nonuveitic secondary glaucoma.Condition
Clinical Trials
Trial Phases
nonuveitic secondary glaucoma
0 Actively Recruiting
Open Angle Glaucoma
11 Actively Recruiting
Phase 3, Not Applicable, Phase 2, Phase 4
Accommodative component in esotropia
0 Actively Recruiting
Glaucoma, Angle-Closure
0 Actively Recruiting
Phospholine Iodide Reviews: What are patients saying about Phospholine Iodide?
5Patient Review
5/14/2013 I use this in one eye to help with my pupil dilation issue.
5Patient Review
2/11/2014 These eye drops not only dilate the pupil, but also help to reduce and control my eye pressure when used in conjunction with another medication.
5Patient Review
7/7/2016 This is the only eye drop that has been able to consistently lower my pressure below 18 for the last few years. Sometimes it can be difficult to obtain, and each bottle only lasts for 28 days, but it WORKS!
Patient Q&A Section about phospholine iodide
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is Phospholine iodide used for?
"This drug is used to lower pressure in the eye for people with glaucoma or other eye problems. It works by shrinking the pupil and reducing the amount of fluid in the eye. It also affects some eye muscles."
Answered by AI
How is Echothiophate administered?
"Echothiophate must be diluted before using. The 0.06% concentration produces the most significant IOP reduction for most patients, which is approximately the same as the peak effect of 4% pilocarpine."
Answered by AI
What drug class is Echothiophate iodide?
"Many organophosphorus compounds are used as pesticides. Some have medical applications, while others are used as oil additives. The general chemical formula for these compounds is (RO)₃PS, [(RO)₂PO]⁻, R(RO)₂PS, etc."
Answered by AI
Who manufactures Phospholine Iodide?
"(n.d.). Retrieved from https://www.pfizermedinfo.com/en-us/phospholine-iodide
Phospholine Iodide is a medication used to treat conditions related to the eye. It is a brand name drug that is manufactured by Pfizer, and its active ingredient is called phospholine iodide. This drug is available in both pill and liquid form, and is taken orally."
Answered by AI