Your session is about to expire
What is Prinzide
LisinoprilThe Generic name of this drug
Treatment SummaryLisinopril is an anti-hypertension medication used to treat high blood pressure, heart failure, and heart attack. It is a type of ACE inhibitor, a group of drugs that are often the first line of treatment for hypertension. Lisinopril works by blocking the action of a certain enzyme and the renin-angiotensin-aldosterone system, which helps to regulate blood pressure. It was approved by the FDA in 1987 and is commonly prescribed to treat hypertension.
Prinivilis the brand name
Prinzide Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Prinivil
Lisinopril
1987
1222
Approved as Treatment by the FDA
Lisinopril, commonly known as Prinivil, is approved by the FDA for 5 uses which include Congestive Heart Failure (CHF) and Hypertensive disease .Congestive Heart Failure (CHF)
Used in combination with other therapies
Hypertensive disease
Helps manage High Blood Pressure (Hypertension)
Acute Myocardial Infarction (AMI)
Helps manage Acute Myocardial Infarction (AMI)
Congestive Heart Failure
Used in combination with other therapies
Heart Attack
Helps manage Acute Myocardial Infarction (AMI)
Effectiveness
How Prinzide Affects PatientsLisinopril helps with high blood pressure, heart failure, and heart attack by blocking enzymes and hormones that work to regulate blood pressure and blood flow. It has a wide range of safe dosages, and most people take 10-80mg every day for long-lasting effects.
How Prinzide works in the bodyLisinopril works by blocking the conversion of angiotensin I to angiotensin II. Angiotensin II is what causes blood vessels to constrict and increases oxygen consumption. Without this, Lisinopril prevents the overgrowth of muscle cells and stops the blood vessels from narrowing. It also increases levels of bradykinin, which has a natural vasodilating effect, helping to keep blood vessels wide open. Lisinopril also stops renin from converting angiotensin to angiotensin I.
When to interrupt dosage
The dosage of Prinzide is dependent upon the confirmed disorder, including Migraine, Congestive Heart Failure and prophylaxis of cardiovascular event. The portion of medication likewise depends on the technique of delivery (e.g. Tablet - Oral or Tablet) outlined in the table beneath.Condition
Dosage
Administration
Migraine
, 2.5 mg, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 0.1 mg, 1.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit, Solution, Solution - Oral
Heart Attack
, 2.5 mg, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 0.1 mg, 1.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit, Solution, Solution - Oral
prophylaxis of cardiovascular event
, 2.5 mg, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 0.1 mg, 1.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit, Solution, Solution - Oral
Congestive Heart Failure
, 2.5 mg, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 0.1 mg, 1.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit, Solution, Solution - Oral
Diabetes
, 2.5 mg, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 0.1 mg, 1.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit, Solution, Solution - Oral
Diabetic Nephropathies
, 2.5 mg, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 0.1 mg, 1.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit, Solution, Solution - Oral
Cardiovascular Events
, 2.5 mg, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 0.1 mg, 1.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit, Solution, Solution - Oral
Migraine Disorders
, 2.5 mg, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 0.1 mg, 1.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit, Solution, Solution - Oral
Hypertensive disease
, 2.5 mg, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 0.1 mg, 1.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit, Solution, Solution - Oral
Warnings
Prinzide has five contraindications. Consequently, it should not be taken in cases of the conditions described in the table below.Prinzide ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Type 2 Diabetes
Do Not Combine
Angioedema
Do Not Combine
Pulse Frequency
Do Not Combine
Angioedemas, Hereditary
Do Not Combine
Common Prinzide Drug Interactions
Drug Name
Risk Level
Description
Amifostine
Major
Lisinopril may increase the hypotensive activities of Amifostine.
Azathioprine
Major
The risk or severity of myelosuppression, anemia, and severe leukopenia can be increased when Lisinopril is combined with Azathioprine.
Lithium carbonate
Major
The serum concentration of Lithium carbonate can be increased when it is combined with Lisinopril.
Lithium citrate
Major
The serum concentration of Lithium citrate can be increased when it is combined with Lisinopril.
Lithium hydroxide
Major
The serum concentration of Lithium hydroxide can be increased when it is combined with Lisinopril.
Prinzide Toxicity & Overdose RiskThe lowest toxic dose of lisinopril in rats has been found to be greater than 8500mg/kg in rats and greater than 9100mg/kg in mice. Those who overdose on lisinopril may experience low blood pressure, which can be reversed by administering saline intravenously. Since lisinopril does not bind to protein, dialysis can be used to remove the drug from the bloodstream.
Prinzide Novel Uses: Which Conditions Have a Clinical Trial Featuring Prinzide?
647 active studies are being conducted to gauge the effectiveness of Prinzide in treating Type 2 Diabetes, Diabetic Nephropathy and Hypertensive Disease.Condition
Clinical Trials
Trial Phases
Migraine Disorders
1 Actively Recruiting
Phase 3
Diabetic Nephropathies
0 Actively Recruiting
prophylaxis of cardiovascular event
0 Actively Recruiting
Congestive Heart Failure
14 Actively Recruiting
Not Applicable, Phase 1, Phase 2
Hypertensive disease
21 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Diabetes
74 Actively Recruiting
Not Applicable, Phase 4, Phase 2, Phase 1, Phase 3
Migraine
50 Actively Recruiting
Phase 4, Not Applicable, Phase 2, Phase 1, Phase 3, Early Phase 1
Cardiovascular Events
5 Actively Recruiting
Not Applicable
Heart Attack
7 Actively Recruiting
Not Applicable, Phase 4, Phase 3
Prinzide Reviews: What are patients saying about Prinzide?
5Patient Review
4/25/2009 I switched to this treatment from atenolol because it was making me lightheaded and my blood pressure wasn't responding well. I much prefer Prinzide oral because the only downside is a occasional cough, which is manageable.
5Patient Review
5/21/2011 This treatment has been great for relieving my itching and swelling. My blood pressure is also down, which is a huge plus.
5Patient Review
9/22/20085Patient Review
12/14/20084.3Patient Review
5/20/2015 There have been times when this pill gets stuck in my throat and it's quite painful. I drink lots of water but my throat still burns for hours afterwards. My voice also becomes hoarse.
4.3Patient Review
4/11/2009 I've only just started taking this medication, but so far it's been going well.
4.3Patient Review
11/10/2010 While this did help my overall condition, I found the side effects to be really tough to deal with. My throat swelled up and I had a hard time coughing.
4.3Patient Review
1/14/2012 I'm not sure if it's a side effect, but this treatment made me cough quite a bit.
4.3Patient Review
4/15/2010 Unfortunately, I had a really severe reaction to this medication. My upper lip swelled up so badly that I went back to the ER. After they gave me a large dose of Benadryl, I finally started to look normal again after about 12 hours.
4Patient Review
9/9/2009 I wish the flavor was better, and that it wasn't so easy to lose track of such a small pill.
3.7Patient Review
3/30/20093.3Patient Review
8/30/2010 I haven't experienced any negative side effects from this medication. I take the smallest dosage available, and then split the dose into two halves - one in the morning, and one at night. This has been effective in keeping my blood pressure level stable.
3Patient Review
12/4/20083Patient Review
12/21/2010 I experienced no negative side effects, but it took a full six months to see any results.
2.7Patient Review
4/20/2009 I had a severe reaction to prinizide that was diagnosed as angio-edema. My face, lips, and cheeks swelled up nearly twice their usual size. It seems I'm allergic to the drug; very scary!!
2.7Patient Review
5/15/2009 Although this medication has only slightly increased my urination, it has lowered my blood pressure from hypertension to a type 1. I am hoping that with further exercise, it will lower even more.
2.3Patient Review
12/4/20082Patient Review
1/14/2011 I found that this medication made it difficult to speak clearly and think straight. I also experienced jerking in my limbs, which was unpleasant.
Patient Q&A Section about prinzide
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What are side effects of Prinzide?
"You may experience dizziness, lightheadedness, tiredness, depression, or headache as your body adjusts to the medication."
Answered by AI
How long does it take for Prinzide to work?
"The medication may take a few weeks to have its full effect."
Answered by AI
Is Prinzide the same as lisinopril?
"Angiotensin converting enzyme inhibitors are used to treat hypertension, heart failure, and myocardial infarction. Prinivil and Prinzide are two such drugs that contain ACE inhibitors."
Answered by AI
What is the drug Prinzide used for?
"Hydrochlorothiazide is a "water pill" (diuretic) that causes you to make more urine, which helps your body get rid of extra salt and water.
This medication is used to treat high blood pressure. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. This product contains two medications: lisinopril and hydrochlorothiazide. Lisinopril is an ACE inhibitor and works by relaxing blood vessels so that blood can flow more easily. Hydrochlorothiazide is a "water pill" (diuretic) that causes you to make more urine, which helps your body get rid of extra salt and water."
Answered by AI