Prinzide

Migraine, Heart Attack, prophylaxis of cardiovascular event + 6 more
Treatment
5 FDA approvals
20 Active Studies for Prinzide

What is Prinzide

LisinoprilThe Generic name of this drug
Treatment SummaryLisinopril is an anti-hypertension medication used to treat high blood pressure, heart failure, and heart attack. It is a type of ACE inhibitor, a group of drugs that are often the first line of treatment for hypertension. Lisinopril works by blocking the action of a certain enzyme and the renin-angiotensin-aldosterone system, which helps to regulate blood pressure. It was approved by the FDA in 1987 and is commonly prescribed to treat hypertension.
Prinivilis the brand name
image of different drug pills on a surface
Prinzide Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Prinivil
Lisinopril
1987
1222

Approved as Treatment by the FDA

Lisinopril, commonly known as Prinivil, is approved by the FDA for 5 uses which include Congestive Heart Failure (CHF) and Hypertensive disease .
Congestive Heart Failure (CHF)
Used in combination with other therapies
Hypertensive disease
Helps manage High Blood Pressure (Hypertension)
Acute Myocardial Infarction (AMI)
Helps manage Acute Myocardial Infarction (AMI)
Congestive Heart Failure
Used in combination with other therapies
Heart Attack
Helps manage Acute Myocardial Infarction (AMI)

Effectiveness

How Prinzide Affects PatientsLisinopril helps with high blood pressure, heart failure, and heart attack by blocking enzymes and hormones that work to regulate blood pressure and blood flow. It has a wide range of safe dosages, and most people take 10-80mg every day for long-lasting effects.
How Prinzide works in the bodyLisinopril works by blocking the conversion of angiotensin I to angiotensin II. Angiotensin II is what causes blood vessels to constrict and increases oxygen consumption. Without this, Lisinopril prevents the overgrowth of muscle cells and stops the blood vessels from narrowing. It also increases levels of bradykinin, which has a natural vasodilating effect, helping to keep blood vessels wide open. Lisinopril also stops renin from converting angiotensin to angiotensin I.

When to interrupt dosage

The dosage of Prinzide is dependent upon the confirmed disorder, including Migraine, Congestive Heart Failure and prophylaxis of cardiovascular event. The portion of medication likewise depends on the technique of delivery (e.g. Tablet - Oral or Tablet) outlined in the table beneath.
Condition
Dosage
Administration
Migraine
, 2.5 mg, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 0.1 mg, 1.0 mg/mL
, Tablet, Tablet - Oral, Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral, Kit
Heart Attack
, 2.5 mg, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 0.1 mg, 1.0 mg/mL
, Tablet, Tablet - Oral, Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral, Kit
prophylaxis of cardiovascular event
, 2.5 mg, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 0.1 mg, 1.0 mg/mL
, Tablet, Tablet - Oral, Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral, Kit
Congestive Heart Failure
, 2.5 mg, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 0.1 mg, 1.0 mg/mL
, Tablet, Tablet - Oral, Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral, Kit
Diabetes
, 2.5 mg, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 0.1 mg, 1.0 mg/mL
, Tablet, Tablet - Oral, Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral, Kit
Diabetic Nephropathies
, 2.5 mg, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 0.1 mg, 1.0 mg/mL
, Tablet, Tablet - Oral, Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral, Kit
Cardiovascular Events
, 2.5 mg, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 0.1 mg, 1.0 mg/mL
, Tablet, Tablet - Oral, Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral, Kit
Migraine Disorders
, 2.5 mg, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 0.1 mg, 1.0 mg/mL
, Tablet, Tablet - Oral, Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral, Kit
Hypertensive disease
, 2.5 mg, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 0.1 mg, 1.0 mg/mL
, Tablet, Tablet - Oral, Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral, Kit

Warnings

Prinzide has five contraindications. Consequently, it should not be taken in cases of the conditions described in the table below.Prinzide Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Type 2 Diabetes
Do Not Combine
Angioedema
Do Not Combine
Pulse Frequency
Do Not Combine
Angioedemas, Hereditary
Do Not Combine
There are 20 known major drug interactions with Prinzide.
Common Prinzide Drug Interactions
Drug Name
Risk Level
Description
Amifostine
Major
Lisinopril may increase the hypotensive activities of Amifostine.
Azathioprine
Major
The risk or severity of myelosuppression, anemia, and severe leukopenia can be increased when Lisinopril is combined with Azathioprine.
Lithium carbonate
Major
The serum concentration of Lithium carbonate can be increased when it is combined with Lisinopril.
Lithium citrate
Major
The serum concentration of Lithium citrate can be increased when it is combined with Lisinopril.
Lithium hydroxide
Major
The serum concentration of Lithium hydroxide can be increased when it is combined with Lisinopril.
Prinzide Toxicity & Overdose RiskThe lowest toxic dose of lisinopril in rats has been found to be greater than 8500mg/kg in rats and greater than 9100mg/kg in mice. Those who overdose on lisinopril may experience low blood pressure, which can be reversed by administering saline intravenously. Since lisinopril does not bind to protein, dialysis can be used to remove the drug from the bloodstream.
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Prinzide Novel Uses: Which Conditions Have a Clinical Trial Featuring Prinzide?

647 active studies are being conducted to gauge the effectiveness of Prinzide in treating Type 2 Diabetes, Diabetic Nephropathy and Hypertensive Disease.
Condition
Clinical Trials
Trial Phases
Migraine
51 Actively Recruiting
Phase 4, Not Applicable, Phase 1, Phase 3, Phase 2, Early Phase 1
Congestive Heart Failure
11 Actively Recruiting
Not Applicable, Phase 1, Phase 2
Migraine Disorders
1 Actively Recruiting
Phase 3
Diabetes
74 Actively Recruiting
Phase 1, Not Applicable, Phase 4, Phase 2, Phase 3
Diabetic Nephropathies
0 Actively Recruiting
prophylaxis of cardiovascular event
0 Actively Recruiting
Hypertensive disease
27 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Cardiovascular Events
4 Actively Recruiting
Not Applicable
Heart Attack
4 Actively Recruiting
Not Applicable, Phase 3

Prinzide Reviews: What are patients saying about Prinzide?

5Patient Review
4/25/2009
Prinzide for High Blood Pressure
I switched to this treatment from atenolol because it was making me lightheaded and my blood pressure wasn't responding well. I much prefer Prinzide oral because the only downside is a occasional cough, which is manageable.
5Patient Review
5/21/2011
Prinzide for High Blood Pressure
This treatment has been great for relieving my itching and swelling. My blood pressure is also down, which is a huge plus.
5Patient Review
9/22/2008
Prinzide for High Blood Pressure
5Patient Review
12/14/2008
Prinzide for High Blood Pressure
4.3Patient Review
5/20/2015
Prinzide for High Blood Pressure
There have been times when this pill gets stuck in my throat and it's quite painful. I drink lots of water but my throat still burns for hours afterwards. My voice also becomes hoarse.
4.3Patient Review
4/11/2009
Prinzide for High Blood Pressure
I've only just started taking this medication, but so far it's been going well.
4.3Patient Review
11/10/2010
Prinzide for High Blood Pressure
While this did help my overall condition, I found the side effects to be really tough to deal with. My throat swelled up and I had a hard time coughing.
4.3Patient Review
1/14/2012
Prinzide for High Blood Pressure
I'm not sure if it's a side effect, but this treatment made me cough quite a bit.
4.3Patient Review
4/15/2010
Prinzide for High Blood Pressure
Unfortunately, I had a really severe reaction to this medication. My upper lip swelled up so badly that I went back to the ER. After they gave me a large dose of Benadryl, I finally started to look normal again after about 12 hours.
4Patient Review
9/9/2009
Prinzide for High Blood Pressure
I wish the flavor was better, and that it wasn't so easy to lose track of such a small pill.
3.7Patient Review
3/30/2009
Prinzide for High Blood Pressure
3.3Patient Review
8/30/2010
Prinzide for High Blood Pressure
I haven't experienced any negative side effects from this medication. I take the smallest dosage available, and then split the dose into two halves - one in the morning, and one at night. This has been effective in keeping my blood pressure level stable.
3Patient Review
12/4/2008
Prinzide for High Blood Pressure
3Patient Review
12/21/2010
Prinzide for High Blood Pressure
I experienced no negative side effects, but it took a full six months to see any results.
2.7Patient Review
4/20/2009
Prinzide for High Blood Pressure
I had a severe reaction to prinizide that was diagnosed as angio-edema. My face, lips, and cheeks swelled up nearly twice their usual size. It seems I'm allergic to the drug; very scary!!
2.7Patient Review
5/15/2009
Prinzide for High Blood Pressure
Although this medication has only slightly increased my urination, it has lowered my blood pressure from hypertension to a type 1. I am hoping that with further exercise, it will lower even more.
2.3Patient Review
12/4/2008
Prinzide for High Blood Pressure
2Patient Review
1/14/2011
Prinzide for High Blood Pressure
I found that this medication made it difficult to speak clearly and think straight. I also experienced jerking in my limbs, which was unpleasant.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about prinzide

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are side effects of Prinzide?

"You may experience dizziness, lightheadedness, tiredness, depression, or headache as your body adjusts to the medication."

Answered by AI

How long does it take for Prinzide to work?

"The medication may take a few weeks to have its full effect."

Answered by AI

Is Prinzide the same as lisinopril?

"Angiotensin converting enzyme inhibitors are used to treat hypertension, heart failure, and myocardial infarction. Prinivil and Prinzide are two such drugs that contain ACE inhibitors."

Answered by AI

What is the drug Prinzide used for?

"Hydrochlorothiazide is a "water pill" (diuretic) that causes you to make more urine, which helps your body get rid of extra salt and water.

This medication is used to treat high blood pressure. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. This product contains two medications: lisinopril and hydrochlorothiazide. Lisinopril is an ACE inhibitor and works by relaxing blood vessels so that blood can flow more easily. Hydrochlorothiazide is a "water pill" (diuretic) that causes you to make more urine, which helps your body get rid of extra salt and water."

Answered by AI

Clinical Trials for Prinzide

Image of U Health in Miami, United States.

Cuffless PPG Monitor for High Blood Pressure

18+
All Sexes
Miami, FL
This study aims to validate the accuracy and reliability of blood pressure (BP) estimates obtained over 24 hours using a PPG-based chest-patch device compared to the gold standard ambulatory blood pressure monitoring (ABPM) method using an upper arm cuff-based oscillometric BP device, in both hypertensive and normotensive individuals referred by their provider to undergo a 24-hours ABPM for clinical indication. The Awake/Asleep test, which is the primary test recommended for automated wearable cuffless BP devices that are cuff-calibrated (based on the 2023 European Society of Hypertension (ESH) recommendations for the validation of cuffless blood pressure measuring devices), will be conducted in this study. The secondary aim of the study is to assess the feasibility and convenience of the PPG-based device.
Waitlist Available
Has No Placebo
U Health (+1 Sites)Ziad Zoghby, M.D., M.B.A.Biobeat Technologies Ltd.
Image of UConn Health in Farmington, United States.

Digital Exercise Prescription Tool for Cardiovascular Disease

18 - 64
All Sexes
Farmington, CT
The investigators will conduct a feasibility and pilot efficacy randomized controlled trial to test the usability and user satisfaction of an evidence-based digital health tool the investigators developed for physicians to use to Prioritize Personalize Prescribe EXercise (P3-EX) to patients with cardiovascular disease (CVD) risk factors. The investigators will recruit 24 physicians from two local hospitals in CT, USA. Physicians will recruit two patients each (N=48) having CVD risk factors. Physicians will deliver a P3-EX exercise prescription (ExRx) to one of their patients (n=24) and the American College of Sports Medicine Physical Activity Vital Sign (ACSM-PAVS) ExRx to the other (n=24) in a random sequence crossover design. Physicians and patients will rate the feasibility and acceptability of each method using validated questionnaires. Patients will perform their prescribed ExRx for 12 weeks and complete a self-report exercise diary to monitor exercise adherence with virtual oversight from University of Connecticut (UConn) Graduate Research Assistants. Before and after the exercise intervention, the investigators will measure patient CVD risk factors and physical activity (PA) levels via accelerometry. The primary aim is to evaluate the feasibility and acceptability of P3-EX for physicians to use to prescribe exercise to patients with CVD risk factors, and the secondary aim is to explore the preliminary efficacy of P3-EX to improve patient CVD risk factors, PA levels, and exercise adherence. The investigators hypothesize P3-EX will be feasible for physicians to use to prescribe customized exercise routines for patients with CVD risk factors, and physicians and patients will be satisfied with P3-EX.
Waitlist Available
Has No Placebo
UConn Health (+2 Sites)Linda S Pescatello, PhD
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Exendin-9 + Dexamethasone for Insulin Resistance

18 - 60
All Sexes
Durham, NC
Glucagon secretion from α-cells has long been viewed as primarily a counterregulatory mechanism - e.g. an agent with a role to prevent blood sugar from decreasing to levels that compromise function. Our group, along with other researchers, have begun to identify a much more complex role for α-cells, raising questions about when and how glucagon may influence blood glucose levels. This proposal looks to detail proglucagon peptide secretion from α-cells and the impact this has on β-cell function and glucose tolerance, in preclinical studies of human islets and translational studies in human subjects. This protocol registration describes Aim 2 from this NIH grant which involves 2 study populations and separate protocols but addresses a common question. Aim 3 in the grant is focused on a separate hypothesis and will be conducted and published separately from Aim 2.
Phase 1
Recruiting
Duke Center for LivingDavid D'Alessio, MD
Have you considered Prinzide clinical trials? We made a collection of clinical trials featuring Prinzide, we think they might fit your search criteria.Go to Trials
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Embolization for Migraine

18 - 80
All Sexes
Baltimore, MD
This study is to test the safety and feasibility of a procedure called embolization of the middle meningeal arteries (MMA), using a product called Onyx. Embolization creates a plug in the arteries. MMA embolization with Onyx is not approved for use in patients with migraines, but is currently used in patients with subdural hematomas. The FDA is allowing the use of Onyx in this study. It is thought that by using Onyx to block the middle meningeal arteries, the amount of migraine-causing substances which are released into the brain's bloodstream will be reduced. The company that manufactures Onyx, Medtronic, is providing the supplies for this study. Participants will be in the study for about 8 months after enrolling, including 6 months of follow up after the procedure. The participants will be asked to complete a daily headache diary and continue the participant's regular migraine medications. Participants will also have several clinic visits and be asked to provide blood samples for research.
Waitlist Available
Has No Placebo
Johns Hopkins MedicineRisheng Xu, MD, PhDMedtronic
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Continuous Glucose Monitors for Diabetes

18 - 90
All Sexes
Baltimore, MD
Among the diffident groups of patients, those with chronic and severe medical conditions are more likely to be readmitted to the hospital. It is not surprising therefore that patients with diabetes have high readmission rates. Patients with diabetes have 40% higher re-hospitalization rates compared with those patients without diabetes, with 30-day readmission rates reported to range between 14% and 26%. It should be noted that almost 30% of the patients with diabetes are experiencing two or more hospital admissions per year, accounting for more than 50% of total hospitalizations and hospital health care costs. This research application will evaluate whether the initiation of Continuous Glucose Monitor (CGM) devices at the time of hospital discharge will lead to better glucose control and health outcomes compared to the use of "finger sticks" Point of Care (POC) following hospital discharge among patients with diabetes. This study will be a two arm (Real Time CGM vs POC) single center RCT at the Baltimore VA Medical Center. One hundred and twenty individuals will be recruited and randomly assigned (1:1) to either Real Time CGM or to POC following hospital discharge. All subjects will be followed from for 3 months post hospital discharge.
Waitlist Available
Has No Placebo
Baltimore VA Medical CenterIlias Spanakis, MDDexCom, Inc.
Have you considered Prinzide clinical trials? We made a collection of clinical trials featuring Prinzide, we think they might fit your search criteria.Go to Trials
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Continuous Glucose Monitor + Nutrition Counseling for Type 2 Diabetes

18+
All Sexes
Chapel Hill, NC
This study is designed to test the feasibility and preliminary efficacy of a continuous glucose monitor (CGM)-augmented food is medicine (FIM) intervention for adults with type 2 diabetes and nutrition or food insecurity. This study will learn if a FIM intervention ("intervention") that includes access to real-time CGM and nutrition counseling can increase engagement, improve glycemic management, and support healthy eating in this population, compared to the FIM intervention alone ("comparator"). At the study baseline, participants will be randomized to either the intervention or the comparator arm for 16 weeks. The intervention will occur during the first 12 weeks (phase 1: intervention phase) and will be compared to a standard FIM approach without CGM or counseling. Phase 2 (extension phase) will last 4 weeks and will consist of all participants in the intervention and comparator arm receiving both FIM and CGM for self-directed use. The study will also explore participant experiences through a series of semi-structured interviews with a subset of randomly selected participants to identify opportunities for scaling the intervention to a broader population.
Recruiting
Has No Placebo
University of North Carolina at Chapel HillAnna Kahkoska, MD, PhD
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Dietary Interventions for Hypertension

18+
All Sexes
Birmingham, AL
Natriuretic peptides (NPs) are hormones produced by the heart and play an important role in maintaining cardiovascular health and have favorable metabolic benefits. Low NP levels are associated with an increased likelihood of the development of cardiometabolic diseases like diabetes and hypertension. NP levels are known to be highly heritable, with up to half of the differences in NP levels being explained by genetics. The investigators aim to describe the genetic architecture of NPs by examining the genetic variants associated with NPs, and generate and validate a polygenic score (PGS) for NPs. The investigators will use this NP PGS to examine the association of genetically determined NP levels with cardiometabolic and cardiovascular outcomes. The investigators will conduct a genotype-guided physiological clinical trial that aims to assess the genetic factors affecting NP levels and their impact on blood pressure and NP response to saline infusion, high-salt diet, and low-salt diet. These findings will help support personal medicine approaches to lower the increasing burden of hypertension in the United States.
Waitlist Available
Has No Placebo
University of Alabama at BirminghamPankaj Arora, MD, FAHA
Have you considered Prinzide clinical trials? We made a collection of clinical trials featuring Prinzide, we think they might fit your search criteria.Go to Trials
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