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Topical Retinoid

Topical Acne Medications for Acne

Phase < 1
Recruiting
Led By Steven R Feldman, MD, PhD
Research Sponsored by Wake Forest University Health Sciences
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Patients with a current diagnosis of acne
Be older than 18 years old
Must not have
Patients without a sufficient command of the English language
Patients without a current diagnosis of acne
Timeline
Screening 3 weeks
Treatment Varies
Follow Up end of study visit - day 56
Awards & highlights
No Placebo-Only Group

Summary

This trial found that acne patients often don't take medications as prescribed, leading to treatment failure, increased healthcare costs & lower quality of life.

Who is the study for?
This trial is for adults over 18 living in the US with a current acne diagnosis who can communicate well in English. It's not for those without an acne diagnosis, under 18, non-US residents, or those who don't speak English sufficiently.
What is being tested?
The study tests daily use of adapalene gel alone and combined with benzoyl peroxide/clindamycin phosphate gel to treat acne. The goal is to see which treatment works better and how patients stick with them.
What are the potential side effects?
Possible side effects include skin irritation, dryness, redness, peeling at the application site. Some may experience allergic reactions or increased sensitivity to sunlight.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am currently diagnosed with acne.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
Select...
I am not fluent in English.
Select...
I do not have a current diagnosis of acne.
Select...
I am under 18 years old.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~end of study visit - day 56
This trial's timeline: 3 weeks for screening, Varies for treatment, and end of study visit - day 56 for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Medication Adherence
Secondary study objectives
Gender specific adherence (female subjects)
Gender specific adherence (male subjects)

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

3Treatment groups
Experimental Treatment
Group I: Two gel treatmentExperimental Treatment1 Intervention
One-third of the participants will be instructed to apply adapalene and the clindamycin phosphate/benzoyl peroxide gel every day.
Group II: Three gel treatmentExperimental Treatment1 Intervention
One-third of the participants will be instructed to apply adapalene, benzoyl peroxide gel, and clindamycin phosphate gel every day.
Group III: One gel treatmentExperimental Treatment1 Intervention
Every participant will be instructed to apply a topical retinoid every day.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Adapalene Gel
2018
Completed Phase 4
~1650

Find a Location

Who is running the clinical trial?

Wake Forest University Health SciencesLead Sponsor
1,395 Previous Clinical Trials
2,460,133 Total Patients Enrolled
Bausch Health Americas, Inc.Industry Sponsor
262 Previous Clinical Trials
81,858 Total Patients Enrolled
6 Trials studying Acne
2,226 Patients Enrolled for Acne
Steven R Feldman, MD, PhDPrincipal InvestigatorWake Forest University Health Sciences
14 Previous Clinical Trials
531 Total Patients Enrolled

Media Library

Adapalene Gel (Topical Retinoid) Clinical Trial Eligibility Overview. Trial Name: NCT05582434 — Phase < 1
Acne Research Study Groups: One gel treatment, Two gel treatment, Three gel treatment
Acne Clinical Trial 2023: Adapalene Gel Highlights & Side Effects. Trial Name: NCT05582434 — Phase < 1
Adapalene Gel (Topical Retinoid) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05582434 — Phase < 1
~26 spots leftby May 2025
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