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MRI + iEEG for Epilepsy

Phase < 1

Recruiting

Led By Kathryn A Davis, MD, MSTR

Research Sponsored by University of Pennsylvania

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Patients with medication-refractory epilepsy

Be older than 18 years old

Must not have

Prior intracranial surgery or device

Timeline

Screening 3 weeks

Treatment Varies

Follow Up measure will be assessed upon collection of patient pre-implant 3t and 7t mri studies and ieeg recordings, and control mri

Awards & highlights

No Placebo-Only Group

Summary

This trial will help researchers develop noninvasive imaging biomarkers to predict how well a person will respond to epilepsy surgery, paving the way for less invasive, better-targeted interventions.

Who is the study for?

This trial is for individuals with drug-resistant epilepsy who are scheduled to have intracranial EEG (IEEG) placement and are thought to have temporal lobe epilepsy. It's not suitable for those with non-diagnostic IEEG results, contraindications to MRI like metal implants or claustrophobia, pregnant individuals, or those who've had prior brain surgery.

What is being tested?

The study tests the use of high-resolution MRIs at 7T and standard 3T alongside IEEG recordings to develop imaging biomarkers that could predict the outcomes of epilepsy surgery. The goal is to improve surgical strategies for seizure control in people with focal drug-resistant epilepsy.

What are the potential side effects?

While this study does not involve drugs, there may be risks associated with undergoing MRIs such as discomfort from loud noises or lying still, and potential issues related to IEEG such as infection risk or discomfort at electrode sites.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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My epilepsy does not improve with medication.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

Select...

I have had brain surgery or a device implanted in my brain.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ measure will be assessed upon collection of patient pre-implant 7t rsfmri and ieeg recordings, and control 7t mri

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~measure will be assessed upon collection of patient pre-implant 7t rsfmri and ieeg recordings, and control 7t mri

This trial's timeline: 3 weeks for screening, Varies for treatment, and measure will be assessed upon collection of patient pre-implant 7t rsfmri and ieeg recordings, and control 7t mri for reporting.