Comparison of 129Xe MRI With 19F MRI in CF Lung Disease

Recruiting in Palo Alto (17 mi)

Overseen byJennifer Goralski, MD

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Phase < 1

Waitlist Available

Sponsor: University of North Carolina, Chapel Hill

No Placebo Group

Trial Summary

What is the purpose of this trial?

This study is designed to compare the capabilities of two novel imaging techniques: polarized perfluorinated gas mixed with oxygen, and hyperpolarized xenon mixed with N2 to detect changes in lung ventilation using MRI.

Eligibility Criteria

Inclusion Criteria

Subjects must be at least 18 years of age;

Non-smokers (<10 pack year history and no active smoking in the past year);

Diagnosis of cystic fibrosis as via standard sweat chloride/phenotypic features/genotyping

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Treatment Details

Interventions

Hyperpolarized Xenon gas (Gas)
PFP (Gas)

Participant Groups

2Treatment groups

Experimental Treatment

Group I: 19F MRI with PFPExperimental Treatment2 Interventions

PFP gas will be administered using a full-face mask during the MRI. Images are acquired during 12-second breath-hold after every 3rd breath. After the MRI is complete, participant performs spirometry maneuvers in a room outside the magnet. Once a minimum of 15 minutes has elapsed since leaving the MRI scanner, the participant returns to the MRI scanner, where he/she will self-administer hyperpolarized xenon gas prior to acquiring MRI images. MRI imaging will be taken during approximately 15-second breath-holds.

Group II: 129Xe MRIExperimental Treatment2 Interventions

Participants will self-administer hyperpolarized xenon gas via inhalation prior to the investigators acquiring MRI images. MRI imaging will be taken during approximately 15-second breath-holds. After the MRI is complete, participant performs spirometry maneuvers in a room outside the magnet. Once a minimum of 15 minutes has elapsed since leaving the MRI scanner, the participant will return to the MRI scanner, where the second phase of the study will occur. PFP gas will be administered using a full-face mask during the MRI. Images are acquired during 12-second breath-hold after every 3rd breath.