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Motor Learning for Stroke Recovery

Phase < 1

Recruiting

Led By Kristan Leech, PT, DPT, PhD

Research Sponsored by University of Southern California

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Independently ambulatory (including the use of assistive devices)

Unilateral stroke

Must not have

Aphasia (expressive, receptive, or global)

Inability to give informed consent

Timeline

Screening 3 weeks

Treatment Varies

Follow Up measured after motor learning in each testing session; participants will complete 2 testing sessions over approximately 1 months

Awards & highlights

No Placebo-Only Group

Summary

This trial looks to improve walking in older adults post-stroke through a mix of biomechanical, neuropsychological, and brain imaging methods. It could lead to better treatment approaches to help those affected. #stroke

Who is the study for?

This trial is for older adults who had a stroke at least 6 months ago, can walk (with or without help), and have no severe cognitive deficits, dementia, uncontrolled high blood pressure, ongoing physical therapy for other conditions, or any metal implants that interfere with MRI scans.

What is being tested?

The study aims to understand how cognitive impairments after a stroke affect the ability to learn new walking skills. It involves explicit and implicit motor learning tests combined with brain imaging and biomechanical analysis to see how these factors interact.

What are the potential side effects?

There may be minimal side effects from participating in this trial as it mainly involves assessments and non-invasive brain imaging. However, some participants might experience fatigue during motor learning tasks or discomfort from being in an MRI machine.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I can walk on my own, even if I need a device to help.

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I had a stroke that affected only one side of my body.

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I can walk for 5 minutes without needing to stop.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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I have difficulty speaking or understanding speech.

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I am unable to understand and agree to the study's details.

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I have a condition affecting my movement or brain function that could interfere with testing.

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I have had a stroke in my brainstem or cerebellum.

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My blood pressure is not higher than 160/110 mmHg.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ measured after motor learning in each testing session; participants will complete 2 testing sessions over approximately 1 months

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~measured after motor learning in each testing session; participants will complete 2 testing sessions over approximately 1 months

This trial's timeline: 3 weeks for screening, Varies for treatment, and measured after motor learning in each testing session; participants will complete 2 testing sessions over approximately 1 months for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

step length asymmetry - change in performance

Secondary study objectives

step length asymmetry - immediate retention

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups

Experimental Treatment

Group I: Evaluating motor learning and brain structures post-strokeExperimental Treatment2 Interventions

We will use a single arm design to determine the impact of post-stroke cognitive impairment on two forms of motor learning (implicit and explicit) and evaluate the structural integrity of relevant brain structures in 65 individuals post stroke

0 / 8Eligibility criteria met