Dynamic FAZA PET and Multiparametric MR Imaging for Brain Tumor

Recruiting in Palo Alto (17 mi)

Caroline Chung | MD Anderson Cancer Center

Overseen byCaroline Chung

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Phase < 1

Waitlist Available

Sponsor: M.D. Anderson Cancer Center

No Placebo Group

Trial Summary

What is the purpose of this trial?Primary Objectives To investigate the relationship between dynamic MRI, brain tumor perfusion (DSC) and permeability (DCE), and dynamic 18F-FAZA PET uptake. Secondary Objectives To investigate the relationship between tumors with greater hypoxia defined by qBOLD and 18F-FAZA PET and pathological features including proportionate necrosis, Ki-67 and IDH mutation status To investigate the correlation between the hypoxic tumor region delineated using 18F-FAZA PET and qBOLD

Eligibility Criteria

This trial is for adults over 18 with high grade glioma (brain tumor) or newly diagnosed cervical cancer. Participants must be receiving surgery, radiotherapy, or chemotherapy and have no issues with MRI or PET scans using specific contrasts. They should be able to give informed consent.

Inclusion Criteria

I am an adult woman with new cervical cancer, getting treatment, and can have MRI or PET scans.

I am an adult with a new or returning high-grade brain tumor and can undergo MRI and PET scans.

Exclusion Criteria

Glioma Cohort: Patients with prior nephrectomy or planned nephrectomy, prior brain radiation within 30 days, pregnant or lactating women, subjects with contraindications to the use of 18F-FAZA, patients with a body weight of 400 pounds or more, or BMI precluding entry into the PET-MRI scanner, and those with any additional medical condition, serious concurrent illness, or other extenuating circumstance that may significantly interfere with study compliance

I do not have conditions that prevent PET-MRI scans or weigh over 400 pounds.

Participant Groups

The study is testing the use of dynamic FAZA PET scans and multiparametric MR imaging to evaluate oxygen levels, metabolism, and blood supply in brain tumors and cervical cancers. It aims to understand how these factors relate to each other.

1Treatment groups

Experimental Treatment

Group I: 18F-FTXExperimental Treatment1 Intervention

The radioactive tracer (FAZA)