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Alkylating agents

Paclitaxel/carboplatin with custirsen for Cancer

Phase 1
Waitlist Available
Research Sponsored by Achieve Life Sciences
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 0, 1, 2, 3, 3.25, 3.67, 4.5, 6, 8, 12, 24 and 48 hours after the start of paclitaxel infusion
Awards & highlights

Study Summary

The primary goal of this study is to determine if custirsen has an effect on the way the body distributes and gets rid of paclitaxel, the standard administered chemotherapy. The study will also evaluate if custirsen influences the way the body distributes and gets rid of carboplatin (another standard administered chemotherapy) and will measure custirsen blood levels in this cancer population. Finally, the study will evaluate the safety and tolerability of adding custirsen to the standard paclitaxel/carboplatin chemotherapy.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~0, 1, 2, 3, 3.25, 3.67, 4.5, 6, 8, 12, 24 and 48 hours after the start of paclitaxel infusion
This trial's timeline: 3 weeks for screening, Varies for treatment, and 0, 1, 2, 3, 3.25, 3.67, 4.5, 6, 8, 12, 24 and 48 hours after the start of paclitaxel infusion for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Paclitaxel
Secondary outcome measures
To evaluate the safety and tolerability of adding custirsen to standard paclitaxel/carboplatin chemotherapy

Trial Design

1Treatment groups
Experimental Treatment
Group I: Paclitaxel/carboplatin with custirsenExperimental Treatment1 Intervention
Custirsen added to standard paclitaxel/carboplatin chemotherapy
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Custirsen
Not yet FDA approved

Find a Location

Who is running the clinical trial?

Teva Branded Pharmaceutical Products R&D, Inc.Industry Sponsor
251 Previous Clinical Trials
3,485,342 Total Patients Enrolled
Achieve Life SciencesLead Sponsor
35 Previous Clinical Trials
7,732 Total Patients Enrolled
~3 spots leftby Jun 2025
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