Anesthetics for Pain Management During Surgery
(MCA Trial)
Trial Summary
What is the purpose of this trial?
This trial examines how three IV drugs (propofol, dexmedetomidine, fentanyl) affect memory and physiological responses to pain. It targets people experiencing pain to understand how these drugs influence brain activity related to memory and fear, which could help explain anxiety disorders like PTSD. Dexmedetomidine has been shown to improve cognition compared to propofol and may have protective effects against PTSD.
Research Team
Keith M Vogt, MD, PhD
Principal Investigator
University of Pittsburgh
Eligibility Criteria
This trial is for healthy adults aged 18-39, with normal body weight and hearing, who speak English natively and have at least a high school education. Participants must not be taking psychotropic medications or have a history of certain medical conditions like sleep apnea, diabetes, chronic pain disorders, significant cardiac disease, or metal implants that are incompatible with MRI.Inclusion Criteria
Exclusion Criteria
Treatment Details
Interventions
- Dexmedetomidine (Alpha-2 Adrenergic Agonist)
- Fentanyl (Opioid Analgesic)
- Peripheral Nerve Stimulation (Other)
- Placebo (Other)
- Propofol (General Anesthetic)
Dexmedetomidine is already approved in Canada, Japan for the following indications:
- Sedation in intensive care settings
- Procedural sedation
- Sedation in intensive care settings
- Procedural sedation
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Who Is Running the Clinical Trial?
Keith M. Vogt, MD, PhD
Lead Sponsor
National Institute of General Medical Sciences (NIGMS)
Collaborator