Benzoyl Peroxide Gel for Total Hip Arthroplasty

Recruiting in Palo Alto (17 mi)

Overseen byJason M Jennings, MD DPT

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Phase 4

Waitlist Available

Sponsor: Colorado Joint Replacement

No Placebo Group

Prior Safety Data

Trial Summary

What is the purpose of this trial?

This trial investigates how quickly a bacteria known for causing acne grows in patients who have had hip replacement surgery. The goal is to see if this bacteria might be causing infections after the surgery.

Research Team

Jason M Jennings, MD DPT

Principal Investigator

Colorado Joint Replacement

Eligibility Criteria

This trial is for patients aged 18-85 who are undergoing primary hip or knee replacement at Porter Adventist Hospital without a previous joint replacement on the biopsy side. They must not have had a hip infection, be using antibiotics recently, have active psoriatic disease over the hip, Cutibacterium joint infections, or any immunodeficiency diseases.

Inclusion Criteria

I have a natural hip joint and am volunteering for research on knee or hip replacement.

CJR primary joint arthroplasty patients who are receiving care at Porter Adventist Hospital

I have not had joint replacement surgery before and am a patient at this practice.

See 1 more

Exclusion Criteria

I have had a hip infection in the past.

I have active psoriasis or inflammation over my hip.

I have had a total hip replacement surgery on both sides.

See 3 more

Treatment Details

Interventions

Benzoyl peroxide gel (Antibacterial Agent)

Trial OverviewThe study tests Benzoyl peroxide gel's effect on reducing colonization of P acnes bacteria in the skin around the hip area. This bacterium is commonly associated with acne but its role in affecting outcomes after total hip arthroplasty (hip replacement surgery) is unknown.

Participant Groups

2Treatment groups

Experimental Treatment

Active Control

Group I: Experimental Skin Prep with BPOExperimental Treatment1 Intervention

Patients will undergo a skin cleansing protocols using 4% Chlorhexidine gluconate (CHG) cloths. Following the CHG wipes, patients will be prepped with 5% BPO gel applied directly to the biopsy site. After the skin prep, three 3-mm punch (Acu-Punch, Acuderm, Fort Lauderdale, FL) skin biopsies will performed for both an anterior-based hypothetical incision, and for a more lateral/posterior incision, for a total of 6 biopsies taken per subject.

Group II: Standard Skin PrepActive Control1 Intervention

Patients will undergo a skin cleansing protocols using 4% Chlorhexidine gluconate (CHG) cloths. After the skin prep, three 3-mm punch (Acu-Punch, Acuderm, Fort Lauderdale, FL) skin biopsies will performed for both an anterior-based hypothetical incision, and for a more lateral/posterior incision, for a total of 6 biopsies taken per subject.