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Buspirone oral capsule for Opioid Use Disorder

Phase 1
Waitlist Available
Research Sponsored by Johns Hopkins University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 28 days
Awards & highlights
All Individual Drugs Already Approved
Approved for 5 Other Conditions

Summary

This is a pilot study to collect preliminary data to support a grant application. The goal of the study is to evaluate whether the Food and Drug Administration (FDA)-approved and generically-available medication buspirone reduces symptoms of opioid withdrawal among patients undergoing a clinically-indicated and supervised taper from their opioid pain medications. This is premised on strong preclinical scientific support but has not yet be well-examined in humans.

Eligible Conditions
  • Opioid Use Disorder
  • Dependency
  • Chronic Pain
  • Opiate Withdrawal

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~28 days
This trial's timeline: 3 weeks for screening, Varies for treatment, and 28 days for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Opioid Withdrawal Symptom Severity
Taper Completion

Awards & Highlights

All Individual Drugs Already Approved
Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.
Approved for 5 Other Conditions
This treatment demonstrated efficacy for 5 other conditions.

Trial Design

2Treatment groups
Active Control
Placebo Group
Group I: Buspirone oral capsuleActive Control1 Intervention
Buspirone (15 milligrams) administered orally three times per day
Group II: Placebo oral capsulePlacebo Group1 Intervention
Placebo administered orally three times per day

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Who is running the clinical trial?

Johns Hopkins UniversityLead Sponsor
2,317 Previous Clinical Trials
14,871,801 Total Patients Enrolled
~2 spots leftby Oct 2025
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