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Cancer Metabolism Inhibitor

RLY-1971 in Subjects With Advanced or Metastatic Solid Tumors

Phase 1
Waitlist Available
Research Sponsored by Hoffmann-La Roche
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up through study completion (an average of one year)
Awards & highlights
No Placebo-Only Group

Summary

This trial tests a new drug called RLY-1971 in patients with advanced or spreading cancers. It aims to find the safest dose, understand how the drug is processed by the body, and see if it can shrink tumors.

Eligible Conditions
  • Solid Tumors

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~through study completion (an average of one year)
This trial's timeline: 3 weeks for screening, Varies for treatment, and through study completion (an average of one year) for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Maximum Tolerated Dose (MTD)
Recommended Phase 2 Dose (RP2D)
Secondary study objectives
Disease Control Rate (DCR)
Objective Response Rate (ORR)
Plasma concentration levels of RLY-1971
Other study objectives
Changes in phospho-ERK levels
Duration of Response (DOR)
Progression-free Survival (PFS)
+1 more

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups
Experimental Treatment
Group I: RLY-1971 - Dose Escalation/ExpansionExperimental Treatment1 Intervention
Dose Escalation: Oral dose of RLY-1971 until Maximum Tolerated Dose (MTD), and Recommended Phase 2 dose (RP2D) are identified Dose Expansion: Oral dose of RLY-1971 once Maximum Tolerated Dose (MTD), and Recommended Phase 2 Dose (RP2D) are identified.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
RLY-1971
2020
Completed Phase 1
~60

Find a Location

Who is running the clinical trial?

Hoffmann-La RocheLead Sponsor
2,459 Previous Clinical Trials
1,096,988 Total Patients Enrolled
Clinical TrialsStudy DirectorHoffmann-La Roche
2,228 Previous Clinical Trials
895,934 Total Patients Enrolled
~10 spots leftby Dec 2025
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