Deep Brain Stimulation for Parkinson's Disease

Recruiting in Palo Alto (17 mi)

Overseen byKiarash Shahlaie, MD, PhD

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Recruiting

Sponsor: University of California, Davis

No Placebo Group

Trial Summary

What is the purpose of this trial?Deep brain stimulation (DBS) in the dorsal region of the subthalamic nucleus (STN) is very effective for reducing motor symptoms of Parkinson's disease (PD). Modeling studies suggest that this therapy may result in current spread into the ventral STN, causing altered cognitive processes. As a result, current stimulation parameters often lead to worsening in verbal fluency, executive function, and, particularly, cognitive control. There is evidence suggesting that low frequency oscillatory activity occurs across brain circuits important in integrating information for cognition. Preclinical studies and human recording studies indicate these low frequency theta oscillations drive cognitive control during cognitive tasks. Thus, the purpose of this study is to determine the safety, tolerability, and efficacy of low frequency stimulation (LFS) of the ventral STN alongside standard high frequency stimulation (HFS) of the dorsal STN in patients with PD.

Eligibility Criteria

This trial is for adults with advanced Parkinson's Disease who have had a specific type of deep brain stimulation (DBS) surgery using the Boston Scientific VerciseTM system. They must be able to consent, participate in cognitive tests, and not have severe cognitive or physical impairments.

Inclusion Criteria

I have Parkinson's and received a Boston Scientific Vercise DBS implant.

I am 18 years old or older.

You have had the Boston Scientific VerciseTM DBS system implanted for at least 3 months.

+1 more

Exclusion Criteria

I am unable to give consent for myself.

I do not have cognitive or physical impairments that limit my participation in tests.

I am not fluent in English.

+3 more

Participant Groups

The study is testing low frequency stimulation of the ventral STN alongside standard high frequency stimulation of the dorsal STN in patients with Parkinson's. It aims to see if this can improve cognition without worsening motor symptoms.

1Treatment groups

Experimental Treatment

Group I: Sustained Dual Frequency, Dual Region, StimulationExperimental Treatment1 Intervention