Behavioural Intervention
Robotic Gait Training + Physical Therapy for Cerebral Palsy
This trial is testing whether a walking training program using a robotic device is more effective than a regular physical therapy program or a combined robotic and physical therapy program for children with cerebral palsy.
Robotic Ankle Assist Device for Cerebral Palsy
This trial is testing a robotic device that helps move the ankle to improve walking. It targets children with Cerebral Palsy who have difficulty walking. The device either helps the ankle push off the ground or provides resistance to strengthen muscles. Researchers hope this will help children walk faster and farther. The use of robotic devices for ankle rehabilitation in children with cerebral palsy has been explored in various studies, showing potential benefits in improving ankle mobility and walking ability.
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Trials for CP Patients
Behavioural Intervention
Interval Treadmill Training for Cerebral Palsy
This trial will compare the effects of two different types of locomotor training on ambulatory children with cerebral palsy. The first group will do short bursts of intense walking with low/moderate intensity in between. The second group will do traditional locomotor training at a constant low/moderate intensity. The goal is to see if the first group's walking capacity and performance improves more than the second group's, and whether this effect is mediated by improvements in muscle power generation.
Behavioural Intervention
Movement-2-Music Exercise Program for Mobility Disabilities
This trial is testing the effects of an innovative exercise program, movement-2-music (M2M), on health and fitness outcomes in adults with physical/mobility disabilities. One hundred and eight participants will be recruited and randomly enrolled into one of two groups: M2M or waitlist control. The primary aim of this study is to determine the effects of the 12-week M2M program on health and fitness in participants with physical/mobility disabilities. The study will also compare the observed effects of the program to a previous M2M study, and test whether adherence (attendance to the 12-week program) affects the
Device
tDCS + Bimanual Therapy for Cerebral Palsy
This trial will test if a new brain stimulation treatment can improve hand function in children with USCP. Children will be randomly assigned to either receive the new treatment or a fake (sham) treatment.
Trials for Spinal Cord Injury Patients
Behavioural Intervention
Movement-2-Music Exercise Program for Mobility Disabilities
This trial is testing the effects of an innovative exercise program, movement-2-music (M2M), on health and fitness outcomes in adults with physical/mobility disabilities. One hundred and eight participants will be recruited and randomly enrolled into one of two groups: M2M or waitlist control. The primary aim of this study is to determine the effects of the 12-week M2M program on health and fitness in participants with physical/mobility disabilities. The study will also compare the observed effects of the program to a previous M2M study, and test whether adherence (attendance to the 12-week program) affects the
Behavioural Intervention
Neurosleeve for Arm Weakness/Paralysis
This trial is testing the NuroSleeve, a wearable device that helps people with weak or paralyzed arms move them using electrical signals. It is aimed at those who haven't fully recovered with standard therapies. The device detects small muscle movements and uses them to activate the brace and stimulate muscles, helping with arm movement. Electrical stimulation has been explored in various contexts, including improving arm and hand function in individuals with spinal cord injuries and post-stroke patients.
Trials With No Placebo
Behavioural Intervention
Interval Treadmill Training for Cerebral Palsy
This trial will compare the effects of two different types of locomotor training on ambulatory children with cerebral palsy. The first group will do short bursts of intense walking with low/moderate intensity in between. The second group will do traditional locomotor training at a constant low/moderate intensity. The goal is to see if the first group's walking capacity and performance improves more than the second group's, and whether this effect is mediated by improvements in muscle power generation.
Behavioural Intervention
Movement-2-Music Exercise Program for Mobility Disabilities
This trial is testing the effects of an innovative exercise program, movement-2-music (M2M), on health and fitness outcomes in adults with physical/mobility disabilities. One hundred and eight participants will be recruited and randomly enrolled into one of two groups: M2M or waitlist control. The primary aim of this study is to determine the effects of the 12-week M2M program on health and fitness in participants with physical/mobility disabilities. The study will also compare the observed effects of the program to a previous M2M study, and test whether adherence (attendance to the 12-week program) affects the
Device
tDCS + Bimanual Therapy for Cerebral Palsy
This trial will test if a new brain stimulation treatment can improve hand function in children with USCP. Children will be randomly assigned to either receive the new treatment or a fake (sham) treatment.
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Frequently Asked Questions
Introduction to cerebral palsy
What are the top hospitals conducting cerebral palsy research?
In the pursuit of improving the lives of individuals with cerebral palsy, several hospitals and research institutions have taken up the mantle of conducting clinical trials. One such institution is Toronto's Holland Bloorview Kids Rehabilitation Hospital, where they currently have four active trials focused on cerebral palsy. With a total of 18 studies conducted thus far since their first recorded trial in 2009, this hospital has become an important hub for advancing our understanding and treatment options for this condition.
Heading south to Birmingham, Alabama, we find the University of Alabama at Birmingham making significant contributions as well. With three ongoing trials dedicated to cerebral palsy and a commendable history of seven past studies dating back to their pioneering trial in 1996, UAB is playing a vital role in furthering knowledge about this complex disorder.
The University of Washington in Seattle has also joined the ranks by initiating three active clinical trials examining various aspects related to cerebral palsy. Despite having carried out only five previous investigations since recording their first trial in 2013, UW demonstrates promising dedication towards unraveling key insights into better managing this condition.
Closer to home for Canadians lies Montreal's Lethbridge-Layton-Mackay Rehabilitation Center within CIUSSS West-Central Montreal (Mackay site). Although relatively new compared to its counterparts, having just begun its first recorded cerebral palsy trial last year (2020), it already boasts three ongoing studies that aim to make impactful progress towards improving outcomes for those affected by this neurological disorder.
Lastly but no less importantly located at Grand Rapids' Grand Valley State University which might be among newer players within these circles yet already showing great promise through dedicating themselves conducting necessary investigations- debuting with recent initiation-recorded just last year (2021)of initial relevant exploration pertaining around saw including remarkable-three ongoing tests all focusing specifically on cases associated with cerebal-palysy being subject here alongside successful accomplishment exhibiting conduction of four vital earlier studies accomplished here.
These hospitals and research centers are beacons of hope for individuals with cerebral palsy, as they tirelessly work to discover new treatment options and improve quality of life. By pushing boundaries through clinical trials, these institutions bring us closer to a future where those living with cerebral palsy can thrive in every aspect of their lives.
Which are the best cities for cerebral palsy clinical trials?
When it comes to cerebral palsy clinical trials, several cities have emerged as key hubs of research and innovation. Toronto, Ontario leads the pack with 8 active trials focusing on various interventions such as routine observational analysis, Bootle Boot Camp, and metformin. Philadelphia, Pennsylvania closely follows with 7 ongoing studies exploring areas like neurosleeve and telehealth programs. Los Angeles, California also boasts 7 active trials investigating in-home interventions and therapeutic arm approaches for individuals with cerebral palsy. Other notable cities include Birmingham, Alabama and Seattle, Washington which both have 6 active trials underway covering a range of interventions from virtual reality exergaming to intensive training programs. These locations offer promising opportunities for individuals affected by cerebral palsy to participate in cutting-edge clinical trials that may shape future treatment options.
Which are the top treatments for cerebral palsy being explored in clinical trials?
Clinical trials are paving the way for advancements in treating cerebral palsy, with one treatment emerging as a frontrunner. Remote Ischemic Conditioning (RIC) is currently being explored in two active clinical trials dedicated to cerebral palsy. Although it has only recently made its debut in 2021, RIC shows promising potential and offers hope for improving the lives of individuals affected by this condition. As researchers delve deeper into these trials, they move closer towards unveiling new possibilities and treatment options for patients living with cerebral palsy.
What are the most recent clinical trials for cerebral palsy?
Promising advancements in the treatment of cerebral palsy have emerged from recent clinical trials. In one study, participants underwent magic trick training, aimed at improving motor skills and cognitive abilities. Ankle foot orthosis was tested as a potential intervention to enhance mobility in individuals with cerebral palsy. Virtual reality exergaming offered an innovative approach to therapy, utilizing immersive experiences combined with physical activity. Valbenazine, undergoing Phase 3 trials, exhibited potential for managing symptoms associated with cerebral palsy effectively. Another trial explored remote ischemic conditioning (RIC) as a method to mitigate the impact of cerebral palsy on patients' lives. These groundbreaking efforts open new possibilities for improved outcomes and quality of life among those affected by this condition.
What cerebral palsy clinical trials were recently completed?
Several recent clinical trials have made significant strides in advancing the treatment of cerebral palsy. These trials include a study sponsored by Oxford University that investigated the effectiveness of a novel therapy, which was completed in October 2021. Additionally, an international trial led by Johns Hopkins University examined the benefits of early intervention and concluded in September 2021. The completion of these groundbreaking trials highlights the ongoing efforts to improve outcomes for individuals with cerebral palsy and offers hope for future advancements in this field.