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Behavioural Intervention

TMS for PTSD (rTMS for PTSD Trial)

N/A
Recruiting
Led By Bradley V Watts, MD MPH
Research Sponsored by VA Office of Research and Development
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Age between 19 and 70
Be older than 18 years old
Must not have
Significant central nervous system disorder (stroke, brain mass, epilepsy)
Prior use of TMS
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 6 months

Summary

This trial is testing whether transcranial magnetic stimulation, a treatment for depression, is also effective for treating PTSD in veterans.

Who is the study for?
This trial is for Veterans aged 19-70 with moderate to severe PTSD, eligible for VA healthcare. Participants must not be using certain medications like high-dose bupropion or clozapine, have no metal in their head (except dental work), no major CNS disorders, unstable medical conditions, recent seizures, or current psychosis. Women of childbearing potential must use birth control.
What is being tested?
The study tests if Transcranial Magnetic Stimulation (TMS), a non-invasive method using magnets to stimulate the brain, can improve functioning in Veterans with PTSD compared to sham TMS. It's randomized and involves 91 participants who either receive real TMS or a placebo-like sham treatment.
What are the potential side effects?
While the description doesn't specify side effects of TMS, common ones include headache, scalp discomfort at the stimulation site during treatment sessions, lightheadedness and rare risk of seizure.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am between 19 and 70 years old.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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I do not have a major brain condition like a stroke, tumor, or epilepsy.
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I have previously used TMS therapy.
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I am currently taking clozapine or more than 300mg of bupropion daily.
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I have undergone PTSD therapy using CPT or PE in the last 2 months.
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I have had a seizure in the last year.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~6 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 6 months for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
CAPS
QIDS SR-16
WHODAS

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: TMSExperimental Treatment1 Intervention
transcranial magnetic stimulation delivered to the right dorsolateral prefrontal cortex at 1 Hz
Group II: ShamPlacebo Group1 Intervention
sham transcranial magnetic stimulation delivered to the right dorsolateral prefrontal cortex

Find a Location

Who is running the clinical trial?

VA Office of Research and DevelopmentLead Sponsor
1,664 Previous Clinical Trials
3,765,575 Total Patients Enrolled
Bradley V Watts, MD MPHPrincipal InvestigatorWhite River Junction VA Medical Center, White River Junction, VT

Media Library

TMS 1 hz (Behavioural Intervention) Clinical Trial Eligibility Overview. Trial Name: NCT04207346 — N/A
Post-Traumatic Stress Disorder Research Study Groups: TMS, Sham
Post-Traumatic Stress Disorder Clinical Trial 2023: TMS 1 hz Highlights & Side Effects. Trial Name: NCT04207346 — N/A
TMS 1 hz (Behavioural Intervention) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04207346 — N/A
~18 spots leftby Dec 2025
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