Stem Cell Therapy for Alzheimer's Disease

Recruiting in Palo Alto (17 mi)

Overseen byPaul E Schulz, MD

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Phase 1 & 2

Waitlist Available

Sponsor: Paul E Schulz

No Placebo Group

Trial Summary

What is the purpose of this trial?

The goal of this clinical trial is to learn if stem cell therapy works to treat brain inflammation in adults. Inflammation in the brain may be involved in adults who have memory or thinking problems. The stem cells will be taken from participant's fat samples, processed and given back to participants, so they are their own donor. The main questions this trial aims to answer are: * Does stem cell therapy reduce inflammation in the brain? * Does stem cell therapy improve brain activity? * Does stem cell therapy slow down progression to Alzheimer's disease? Participants will: * Have a small fat biopsy taken at a doctor's office to process stem cells * Receive 4 infusions of stem cells, through a vein in the arm over 12 weeks * Visit the clinic every 2-4 weeks for the first 4 months and then every 1-2 months for 8 months for checkups and tests

Eligibility Criteria

This trial is for adults with memory or thinking problems due to conditions like early Alzheimer's or mild cognitive impairment. Participants must be willing to have a small fat biopsy and receive stem cell infusions. Specific eligibility details are not provided, but typically there would be criteria related to age, disease severity, and overall health.

Inclusion Criteria

Has an MRI to evaluate AD pathology (may use previous if within 6mo.)

Has signed an informed consent form before any assessment is performed as part of the study

I am between 60 and 80 years old.

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Exclusion Criteria

I have the TSPO SNP rs6971 mutation.

I have a condition like TBI, PD, or MS that could affect my thinking.

My condition is stable and does not include severe heart, kidney, liver issues, or autoimmune diseases.

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Treatment Details

Interventions

adMSC (Stem Cell Therapy)

Trial OverviewThe study tests whether stem cells derived from participants' own fat can reduce brain inflammation and improve cognitive function in those showing early signs of Alzheimer's. It involves processing these cells and administering them back into the patient through arm vein infusions over 12 weeks.

Participant Groups

1Treatment groups

Experimental Treatment

Group I: adMSCExperimental Treatment1 Intervention

IV-infusions of autologous, adipose-derived, Mesenchymal Stem Cells (adMSCs)