Fludeoxyglucose (FDG) F 18 PET Scan, CT Scan, and Ferumoxtran-10 MRI Scan Before Chemotherapy and Radiation Therapy in Finding Lymph Node Metastasis in Patients With Locally Advanced Cervical Cancer or High-Risk Endometrial Cancer

Recruiting in Palo Alto (17 mi)

+32 other locations

Overseen byMostafa Atri

Age: 18+

Sex: Female

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Phase 1 & 2

Waitlist Available

Sponsor: National Cancer Institute (NCI)

No Placebo Group

Trial Summary

What is the purpose of this trial?

This phase I/II trial is studying how well fludeoxyglucose F 18 PET scan, CT scan, and ferumoxtran-10 MRI scan finds lymph node metastasis before undergoing chemotherapy and radiation therapy in patients with locally advanced cervical cancer or high-risk endometrial cancer. Diagnostic procedures, such as a fludeoxyglucose F 18 positron emission tomography (PET) scan, computed tomography (CT) scan, and ferumoxtran-10 magnetic resonance imaging (MRI) scan, may help find lymph node metastasis in patients with cervical cancer or endometrial cancer.

Research Team

Mostafa Atri

Principal Investigator

NRG Oncology

Eligibility Criteria

Inclusion Criteria

Previously untreated, primary disease

Locoregionally advanced (stage IB2, IIA [>= 4 cm], or IIB-IVA) disease

Any cell type allowed

See 7 more

Treatment Details

Interventions

Computed Tomography (Procedure)
Ferumoxtran-10 (Contrast Agent)
Fludeoxyglucose F 18 (Radiation)
Magnetic Resonance Imaging (Procedure)
Positron Emission Tomography (Procedure)

Participant Groups

1Treatment groups

Experimental Treatment

Group I: Treatment (diagnostic scans, surgery, chemotherapy, radiation)Experimental Treatment7 Interventions

Patients receive fludeoxyglucose F 18 (FDG) IV followed 60 minutes later by positron emission tomography (PET)/CT scanning on day 1. Patients also receive ferumoxtran-10 IV over 30-45 minutes on day 1 (or 24-36 hours before MRI) and undergo MRI on day 2. Patients undergo extraperitoneal, laparoscopic, or trans-peritoneal lymphadenectomy with pelvic and abdominal lymph node biopsy within 2 weeks after PET/CT scan. Patients diagnosed with metastatic disease prior to lymph node biopsy proceed directly to primary treatment. Patients with cervical cancer undergo chemoradiotherapy within 4 weeks of PET/CT scan.