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mRNA Vaccine

mRNA-1468 for Shingles

Phase 1 & 2
Waitlist Available
Research Sponsored by ModernaTX, Inc.
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
In general, do you consider yourself to be in good health?
Have you not ever been vaccinated against chickenpox or shingles?
Timeline
Screening 3 weeks
Treatment Varies
Follow Up day 85 and day 225 (1 and 6 months after the last injection)

Summary

This trial will measure if a vaccine is safe and triggers an immune response in people.

Eligible Conditions
  • Shingles

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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Do you feel like you are healthy overall?
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You have never received a vaccine for chickenpox or shingles.
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You have not had shingles in the last 10 years.
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Are you available and willing to attend up to 10 in-person visits and up to 8 phone calls over a period of about 15 months?
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You must be 50 years old or above.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~day 85 and day 225 (1 and 6 months after the last injection)
This trial's timeline: 3 weeks for screening, Varies for treatment, and day 85 and day 225 (1 and 6 months after the last injection) for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Secondary study objectives
Vaccine Seroresponse Rate of Participants

Trial Design

8Treatment groups
Experimental Treatment
Active Control
Group I: Part 2: mRNA-1468: Dose 6Experimental Treatment1 Intervention
Participants will receive mRNA-1468 by IM injection on Day 1 and Day 57 in Part 2.
Group II: Part 2: mRNA-1468: Dose 5Experimental Treatment1 Intervention
Participants will receive mRNA-1468 by IM injection on Day 1 and Day 57 in Part 2.
Group III: Part 1: mRNA-1468: Dose 4Experimental Treatment1 Intervention
Participants will receive mRNA-1468 by IM injection on Day 1 and Day 57 in Part 1.
Group IV: Part 1: mRNA-1468: Dose 3Experimental Treatment1 Intervention
Participants will receive mRNA-1468 by IM injection on Day 1 and Day 57 in Part 1.
Group V: Part 1: mRNA-1468: Dose 2Experimental Treatment1 Intervention
Participants will receive mRNA-1468 by IM injection on Day 1 and Day 57 in Part 1.
Group VI: Part 1: mRNA-1468: Dose 1Experimental Treatment2 Interventions
Participants will receive placebo by intramuscular (IM) injection on Day 1 followed with mRNA-1468 by IM injection on Day 57 in Part 1.
Group VII: Part 1: ShingrixActive Control1 Intervention
Participants will receive Shingrix by IM injection on Day 1 and Day 57 in Part 1.
Group VIII: Part 2: ShingrixActive Control1 Intervention
Participants will receive Shingrix by IM injection on Day 1 and Day 57 in Part 2.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Placebo
1995
Completed Phase 3
~2670

Find a Location

Logistics

Participation is compensated

You will be compensated for participating in this trial.

Who is running the clinical trial?

ModernaTX, Inc.Lead Sponsor
118 Previous Clinical Trials
61,584,732 Total Patients Enrolled

Media Library

mRNA-1468 (mRNA Vaccine) Clinical Trial Eligibility Overview. Trial Name: NCT05701800 — Phase 1 & 2
Shingles Clinical Trial 2023: mRNA-1468 Highlights & Side Effects. Trial Name: NCT05701800 — Phase 1 & 2
mRNA-1468 (mRNA Vaccine) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05701800 — Phase 1 & 2
Shingles Research Study Groups: Part 1: mRNA-1468: Dose 1, Part 1: mRNA-1468: Dose 2, Part 1: mRNA-1468: Dose 3, Part 1: mRNA-1468: Dose 4, Part 1: Shingrix, Part 2: mRNA-1468: Dose 5, Part 2: mRNA-1468: Dose 6, Part 2: Shingrix
Shingles Patient Testimony for trial: Trial Name: NCT05701800 — Phase 1 & 2
~184 spots leftby Nov 2025
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