Resistant Starch
Potato-Based Supplement for Bone Marrow Transplant Patients
This trial is testing a potato-based resistant starch supplement for patients receiving stem cell transplants. The goal is to see if this supplement can safely and effectively reduce a common complication called acute GVHD by boosting a helpful substance in the gut.
Alkylating agents
Bendamustine +/- Cyclophosphamide to Prevent GVHD Post Stem Cell Transplant for Blood Cancers
This trial is testing bendamustine, with or without cyclophosphamide, to see if it can help prevent GVHD in patients undergoing stem cell transplant.
JAK2/IRAK1/CSF1R Inhibitor
Pacritinib for Chronic Graft-versus-Host Disease
This trial tests pacritinib, a capsule taken by mouth, in adults with moderate or severe chronic graft-versus-host disease (cGVHD) that hasn't responded to other treatments. Pacritinib helps by blocking proteins that cause inflammation and immune issues. Participants will take the drug regularly and have periodic check-ups over an extended period.
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Trials for Graft-versus-Host Disease Patients
Behavioral Intervention
Multidisciplinary Care for Graft-versus-Host Disease
This trial is testing whether a new, multidisciplinary approach to care can improve quality of life, symptoms, and psychological distress for people who have developed GVHD after a stem cell transplant.
Trials for Acute Lymphoblastic Leukemia Patients
Alkylating agents
GVHD Prophylaxis Regimens for Blood Cancer Stem Cell Transplant
This trial is studying two different drug combinations to reduce the risk of a common but serious complication called "graft versus host disease" (GVHD) following a blood stem cell transplant from an unrelated donor to treat blood cancer.
T Cell Depletion
Stem Cell Transplantation for Leukemia
This trial is for cancer patients who need a peripheral blood stem cell transplant. The study is testing how well a selective removal of naïve T cells works in preventing GVHD after the transplant.
Monoclonal Antibodies
Tocilizumab for Blood Cancer Post-Transplant Care
This trial is testing whether ATG can be replaced with tocilizumab in the haplo-cord transplant conditioning regimen to improve immune reconstitution and reduce relapse while preserving low rates of graft failure and graft versus host disease.
Trials With No Placebo
Alkylating agents
Stem Cell Transplant for Severe Aplastic Anemia
This trial is for people with severe aplastic anemia, myelodysplastic syndrome, or paroxysmal nocturnal hemoglobinuria who want to receive a stem cell transplant using peripheral blood stem cells from a family member.
Immunosuppressant
High Dose Thymoglobulin for Graft-versus-Host Disease Prophylaxis
This trial will compare two different doses of ATG (a medication used to prepare the body for a stem cell transplant) to see which is more effective in preventing transplant complications.
Alkylating agents
GVHD Prophylaxis Regimens for Blood Cancer Stem Cell Transplant
This trial is studying two different drug combinations to reduce the risk of a common but serious complication called "graft versus host disease" (GVHD) following a blood stem cell transplant from an unrelated donor to treat blood cancer.
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Frequently Asked Questions
Introduction to gvhd
What are the top hospitals conducting gvhd research?
Groundbreaking research and clinical trials are not limited to the fight against cancer alone. In the field of graft-versus-host disease (GVHD), hospitals across the United States are leading the way in finding innovative treatments. Among these institutions is Boston's Dana Farber Cancer Institute, where seven active GVHD trials are currently underway. This renowned center has dedicated significant resources to understanding this complex condition and developing new therapies. Similarly, Massachusetts General Hospital also contributes to advancing GVHD research with six ongoing trials. These two Boston-based hospitals have become powerhouses in tackling GVHD head-on.
Moving westward, we find another influential player in Seattle: the Fred Hutchinson Cancer Research Center. With five active GVHD trials, this esteemed institution is at the forefront of cutting-edge medical advancements for this challenging disease.
Not to be overlooked is Children's National Medical Center located in Washington D.C., which boasts five active GVHD clinical trials that focus specifically on pediatric patients. Their dedication to improving outcomes for young sufferers of this condition showcases their commitment to providing effective treatments tailored for children.
It comes as no surprise that when discussing groundbreaking medical research, Boston's Dana-Farber Cancer Institute makes a second appearance on our list, demonstrating its unwavering commitment by conducting an additional five active GVHD trials alongside their substantial efforts in battling cancer.
These top hospitals represent a collective effort aimed at unraveling the mysteries surrounding graft-versus-host disease and offering hope to those affected by it. As researchers push boundaries and collaborate across multiple locations nationwide, they bring us closer to finding better treatment options and ultimately improving quality of life for individuals impacted by GVHD around the world
Which are the best cities for gvhd clinical trials?
When it comes to GVHD clinical trials, several cities have emerged as leading hubs for research and innovation. Boston, Massachusetts stands out with 26 active trials investigating treatments such as Abatacept, Exercise interventions, Belumosudil (KD025), and more. New york, New York follows closely behind with 19 ongoing studies that explore options like Prednisone, GDC-8264 at 35 mg dosage, Alpha-1 antitrypsin (AAT), and others. Additionally, Atlanta, Georgia has 14 active trials focusing on Alpha-1 antitrypsin (AAT), Abatacept, Belumosudil (KD025), among others. These cities offer individuals with GVHD access to cutting-edge clinical trials that pave the way for advancements in care and provide hope for improved outcomes.
Which are the top treatments for gvhd being explored in clinical trials?
In the world of clinical trials, several treatments are taking center stage in the exploration of graft-versus-host disease (GVHD). Among these top contenders is ruxolitinib, a promising drug showing great potential with its implementation in ongoing studies. Another frontrunner is tocilizumab, which has been garnering considerable attention for its efficacy in treating GVHD. Additionally, abatacept is also being investigated as a potential treatment option for this challenging condition. These innovative therapies hold promise for advancing our understanding and management of GVHD for better patient outcomes.
What are the most recent clinical trials for gvhd?
Recent clinical trials have brought forth promising developments in the treatment of graft-versus-host disease (GVHD). One notable trial explores the effectiveness of Sitagliptin, Bortezomib, and Cyclophosphamide as a potential therapeutic combination for GVHD. Another investigation focuses on prophylactic measures to prevent GVHD following transplantation. Additionally, GDC-8264 has emerged as an intriguing candidate, demonstrating its potential impact in early-phase studies. Moreover, allogeneic mesenchymal stromal cells (MSCs) are being studied extensively for their efficacy in treating GVHD. Lastly, Pacritinib shows promise as a dual inhibitor that could potentially provide effective outcomes against this complex condition. These recent clinical trials offer hope for improved management and treatment options for patients with GVHD.
What gvhd clinical trials were recently completed?
Several significant clinical trials investigating graft-versus-host disease (GVHD) have recently concluded, bringing us closer to more effective treatments for this complex condition. One notable trial was completed by the National Institutes of Health in October 2021, evaluating the efficacy of a novel drug candidate specifically targeting GVHD. Additionally, a separate study led by Memorial Sloan Kettering Cancer Center wrapped up in September 2021, exploring innovative therapies to mitigate the impact of GVHD on patients' quality of life. These recent milestones highlight the ongoing efforts and dedication within the medical community to combat GVHD and improve outcomes for individuals affected by this challenging condition.