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Targeted Therapy

Experimental Group for Pancreatic Cancer

Phase 1 & 2
Waitlist Available
Led By Devalingam Mahalingam, MD
Research Sponsored by Devalingam Mahalingam
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 2 years
Awards & highlights

Study Summary

This trial will test a new cancer drug, sotorasib, to see if it is safe and effective when combined with standard chemotherapy for treating pancreatic cancer that has progressed after first-line treatment.

Eligible Conditions
  • Pancreatic Cancer
  • KRAS Mutation

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~2 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and 2 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Objective Response Rate (ORR)
Secondary outcome measures
Assess Adverse Events
Disease Control Rate (DCR)
Duration of Response (DoR)
+2 more

Trial Design

1Treatment groups
Experimental Treatment
Group I: Experimental GroupExperimental Treatment6 Interventions
Patients will either receive a combination of: Sotorasib + Liposomal Irinotecan (nal-IRI) + 5 Fluorouracil (5FU) + Leucovorin (LV) OR Sotorasib + Gemcitabine (GEM) + Nab-paclitaxel *The combination of therapy received is based on the participants prior therapy and of the discretion of their treating physician
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Sotorasib
FDA approved
Paclitaxel
FDA approved
Leucovorin
FDA approved

Find a Location

Who is running the clinical trial?

AmgenIndustry Sponsor
1,383 Previous Clinical Trials
1,379,921 Total Patients Enrolled
Devalingam MahalingamLead Sponsor
1 Previous Clinical Trials
Devalingam Mahalingam, MDPrincipal InvestigatorNorthwestern University Feinberg School of Medicine
2 Previous Clinical Trials
30 Total Patients Enrolled
~0 spots leftby Jun 2025
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