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MRI Surveillance for Brain Metastases from Lung Cancer

Phase 2

Recruiting

Led By Michael Farris, MD

Research Sponsored by Wake Forest University Health Sciences

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Histology described as adeno-squamous or not otherwise specified favoring squamous are eligible

Eastern Cooperative Oncology Group (ECOG) performance status of 0 - 3

Timeline

Screening 3 weeks

Treatment Varies

Follow Up at 4 months, 8 months, 14 months, 20 months and 26 months after first radiation therapy treatment

Awards & highlights

No Placebo-Only Group

Summary

This trial looks at using MRI to detect cancer spread to the brain before it causes symptoms.

Who is the study for?

This trial is for adults over 18 with non-squamous locally advanced lung cancer (stages IIIA-IIIC). They must have started radiation therapy within the past 120 days and be able to undergo MRI scans. Pregnant or breastfeeding individuals, those with known brain metastases, or women of childbearing potential not on contraception are excluded.

What is being tested?

The study tests whether regular MRI brain scans after radiation therapy can detect cancer spread to the brain earlier than usual. Participants will receive MRIs using Gadolinium contrast, complete quality of life questionnaires, and provide blood samples.

What are the potential side effects?

Potential side effects may include discomfort from blood draws, allergic reactions to Gadolinium contrast used in MRIs (such as headache or nausea), and anxiety or discomfort from frequent MRI procedures.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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My cancer is identified as adeno-squamous or mainly squamous.

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I can care for myself but may not be able to do heavy physical work.

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I am 18 years old or older.

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My lung cancer is at an advanced stage but has not spread beyond my lungs.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ at 4 months, 8 months, 14 months, 20 months and 26 months after first radiation therapy treatment

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~at 4 months, 8 months, 14 months, 20 months and 26 months after first radiation therapy treatment

This trial's timeline: 3 weeks for screening, Varies for treatment, and at 4 months, 8 months, 14 months, 20 months and 26 months after first radiation therapy treatment for reporting.