Brivaracetam for Alzheimer's Disease
(EHAD Trial)
Trial Summary
What is the purpose of this trial?
The major goals of the study are to 1) characterize hippocampal activity in patients with mild cognitive impairment (MCI) due to Alzheimer's disease (AD) and AD who have suspected hippocampal epileptic activity based on scalp EEG recordings from IRB # 21-001603; 2) study the efficacy of brivaracetam to suppress epileptic activity and pathological high frequency oscilations (pHFOs) during hippocampal depth electrode and scalp EEG in patients with MCI and AD; and 3) investigate the effects of brivaracetam on cognition in an open-label pilot study.
Eligibility Criteria
This trial is for adults aged 45-70 with mild cognitive impairment or Alzheimer's, showing specific epileptic activity on EEG. Participants need a reliable informant and must meet certain criteria including scoring above 18 on the Mini-Mental State Exam. Those with other risk factors for epilepsy, using antiseizure meds, significant brain lesions or systemic illnesses, or affecting CNS medications can't join.Inclusion Criteria
Exclusion Criteria
Treatment Details
Interventions
- Brivaracetam (Anti-epileptic drug)
Brivaracetam is already approved in European Union, United States, Canada, Australia for the following indications:
- Partial-onset seizures with or without secondary generalisation
- Focal (partial) onset seizures in epilepsy patients 1 month of age and older
- Partial-onset seizures with or without secondary generalisation
- Partial-onset seizures with or without secondary generalisation