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Radiation

MRI + CT-Guided Radiation Therapy for Sarcoma

Phase 2
Recruiting
Research Sponsored by Jonsson Comprehensive Cancer Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Histologically confirmed sarcoma
Primary or recurrent disease involving the abdomen or pelvis
Must not have
Active treatment of a separate malignancy
History of prior irradiation to the area targeted for treatment
Timeline
Screening 3 weeks
Treatment Varies
Follow Up at 2 years
Awards & highlights

Summary

"This trial aims to use advanced radiation technology to deliver precise doses of radiation to cancerous tumors while avoiding damage to healthy organs. Participants with sarcoma will receive daily radiation treatment for 5 days a week

Who is the study for?
This trial is for individuals with a diagnosis of sarcoma, specifically in the abdominopelvic region. Participants will undergo radiation therapy daily for 5 days and have their primary tumor surgically removed within 12 weeks after completing radiation. They'll be followed up for 5 years.
What is being tested?
The study tests MRI and CT-guided stereotactic body radiation therapy to target cancerous tumors precisely while sparing vital organs. The goal is to deliver higher doses safely over a short period (5 consecutive days).
What are the potential side effects?
Potential side effects may include skin reactions, fatigue, nausea, discomfort at the treatment site, and other typical risks associated with radiation therapy.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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My sarcoma diagnosis was confirmed through tissue examination.
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My cancer is in my abdomen or pelvis.
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My cancer can be surgically removed.
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I am 12 years old or older.
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I am mostly able to care for myself and remain active.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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I am currently being treated for another cancer.
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I have had radiation therapy on the area that needs treatment now.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~at 2 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and at 2 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Radiation morbidity at 2 years
Secondary outcome measures
Local Control
Regional Control

Trial Design

1Treatment groups
Experimental Treatment
Group I: Arm IExperimental Treatment1 Intervention
MRI or CT-guided SBRT will be delivered in the pre-operative setting. Patients will receive 5.0-6.0 Gy x 5 fractions delivered daily.

Find a Location

Who is running the clinical trial?

Jonsson Comprehensive Cancer CenterLead Sponsor
369 Previous Clinical Trials
29,409 Total Patients Enrolled
~5 spots leftby Oct 2024
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