What side effects are associated with this type of intervention?

Common treatments for prostate cancer include chemotherapy, androgen deprivation therapy (ADT), and other systemic therapies. Chemotherapy, such as docetaxel, can cause side effects like fatigue, nausea, hair loss, and increased risk of infections. ADT, which reduces testosterone levels, can lead to hot flashes, reduced libido, osteoporosis, and cardiovascular issues. Other systemic therapies, like abiraterone, may cause hypertension, hypokalemia, and liver function abnormalities. These treatments aim to manage cancer but come with a range of potential side effects that should be discussed with a healthcare provider.

What prior FDA approvals exist?

The FDA has approved several treatments for prostate cancer, including androgen receptor-targeted therapies such as enzalutamide and abiraterone. These drugs are used to manage metastatic castration-resistant prostate cancer (mCRPC) by inhibiting androgen signaling, which is crucial for prostate cancer growth. Additionally, the FDA has approved the use of PSA (prostate-specific antigen) testing as a screening tool to detect prostate cancer early. The Prostate Cancer Genius App aims to enhance the uptake of PSA testing, particularly among African American men, by improving knowledge and facilitating home-based testing.

What other types of research exist?

<ol> <li>AI-based diagnostic tools: AI applications in urology, such as computer-assisted diagnosis, are expected to revolutionize decision-making and improve early detection of prostate cancer. 2.</li> </ol> High-quality mobile apps: Evaluated using the Mobile Application Rating Scale (MARS), these apps provide educational resources and support for patients with genitourinary cancers. 3. Home-based exercise programs: A 24-week home-based exercise program has shown potential to improve prognosis, physical function, and quality of life in men with prostate cancer. 4. PSMA-targeted PET imaging: Advanced imaging techniques like Ga-68 PSMA-11 and piflufolastat F-18 for early detection and monitoring of prostate cancer recurrence.

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Prostate Cancer Genius App Education for Prostate Cancer (PCGA Trial)

N/A

Waitlist Available

Led By Adam Alexander, PhD

Research Sponsored by University of Oklahoma

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

are between the ages of 55 and 69

self-identify as "male" and "Black or African American"

Must not have

Currently or previously diagnosed with prostate cancer

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 30-days

Awards & highlights

No Placebo-Only Group

Summary

This trial tests the Prostate Cancer Genius App, designed to educate African American men about prostate cancer and help them complete a home-based PSA test. The study involves men aged 55 to 69 from Oklahoma who haven't had a PSA test in a while. The app aims to increase knowledge and screening rates by providing tailored information and guidance.

Who is the study for?

This trial is for African American men aged 55-69 living in Oklahoma who haven't had a PSA screening for prostate cancer in the last two years and have never been diagnosed with prostate cancer.

What is being tested?

The study is testing the Prostate Cancer Genius App against an existing health app to see if it improves knowledge about prostate cancer risk, encourages home-based PSA testing, and is user-friendly over a period of 30 days.

What are the potential side effects?

Since this trial involves educational apps rather than medical treatments, there are no direct physical side effects. However, participants may experience stress or anxiety related to learning about their potential cancer risk.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I am between 55 and 69 years old.

Select...

I am a Black or African American male.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

Select...

I have been diagnosed with prostate cancer.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 30-days

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~30-days

This trial's timeline: 3 weeks for screening, Varies for treatment, and 30-days for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Prostate Cancer Knowledge

Secondary study objectives

PSA screening test completion rates

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: Prostate Cancer Genius appExperimental Treatment1 Intervention

The Prostate Cancer Genius app includes the following components: (1) educational content that is consistent with existing evidence and recommendations for prostate cancer and prostate cancer screening but has been adapted for the African American male population and for adults who read at or below the 8th-grade level; (2) real-time messages about the risks of prostate cancer and the benefits of completing a PSA test, placing a special emphasis on screening considerations for individuals with a family history of prostate cancer and/or lower urinary tract symptoms (measured via the American Urological Association Symptom Score); (3) general trivia that also incorporates quiz questions about prostate cancer and the PSA test; (4) African American-specific testimonials and educational videos; (5) optional counseling by African American prostate cancer survivors; and (6) on-demand, automated ordering of a home-based PSA test.

Group II: Prevention Taskforce appActive Control1 Intervention

The Prevention Taskforce app provides on-demand access to evidence-based recommendations for prostate cancer for men between 55 and 69 (i.e., it can be accessed as needed).

0 / 3Eligibility criteria met

Research Highlights

Information in this section is not a recommendation. We encourage patients to speak with their healthcare team when evaluating any treatment decision.

Mechanism Of Action

Side Effect Profile

Prior Approvals

Other Research

The most common treatments for prostate cancer, particularly advanced stages, include androgen deprivation therapy (ADT), which works by lowering serum testosterone levels to inhibit cancer growth. This can be achieved through surgical castration or medications like luteinizing hormone-releasing hormone (LHRH) agonists and antagonists. Additionally, antiandrogens block the action of testosterone on prostate cancer cells. These treatments are crucial as they help manage symptoms, slow disease progression, and improve survival rates. Understanding these mechanisms is vital for patients, as it underscores the importance of regular monitoring through PSA testing, which can be facilitated by digital platforms like the Prostate Cancer Genius App.

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