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Procedure

Advanced MRI Imaging for Glioblastoma

Phase 3
Waitlist Available
Led By Kunal S Patel
Research Sponsored by Jonsson Comprehensive Cancer Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Documentation of a newly diagnosed World Health Organization (WHO) grade IV glioblastoma as evidenced by clinical features and imaging data
Be older than 18 years old
Must not have
Male or female < 18 years of age
Not medically cleared for surgery
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 2 years
Awards & highlights

Summary

This trial is comparing a new type of MRI imaging called pH weighted chemical exchange saturation transfer (CEST) MRI to the standard MRI imaging for guiding surgical resections in patients with glioblastoma.

Who is the study for?
This trial is for patients with glioblastoma, a type of brain cancer. It's testing if a new MRI technique can help surgeons remove more of the tumor than standard surgery does. Participants should be eligible for surgical resection and meet specific health criteria not detailed here.
What is being tested?
The study compares traditional MRI-guided surgery to pH weighted Chemical Exchange Saturation Transfer (CEST) MRI-based surgery in removing glioblastoma tumors. The goal is to see if CEST MRI can better identify and allow removal of tumor tissue that regular MRIs might miss.
What are the potential side effects?
Since this trial focuses on imaging techniques rather than drugs, side effects are related to the surgical procedure itself or potential reactions to contrast agents used during MRI scans.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I have been diagnosed with a grade IV glioblastoma.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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I am under 18 years old.
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I am not cleared for surgery by a doctor.
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I have had cancer treatment before.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 2 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 2 years for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Progression free survival
Secondary study objectives
Overall survival
Quality of life
Surgical complication rate

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Group II (CEST MRI based surgical resection)Experimental Treatment5 Interventions
Patients undergo surgical resection with intraoperative guidance using CEST MRI. Patients also undergo post operative standard of care radiation therapy over 30 fractions and receive standard of care temozolomide PO for 6 weeks. Additionally, patients undergo MRI during follow up.
Group II: Group I (standard of care surgical resection)Active Control5 Interventions
Patients undergo surgical resection with standard intraoperative guidance using contrast-enhanced MRI. Patients also undergo post operative standard of care radiation therapy over 30 fractions and receive standard of care temozolomide PO for 6 weeks. Additionally, patients undergo MRI during follow up.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Radiation Therapy
2017
Completed Phase 3
~7250
Surgical Procedure
2020
Completed Phase 2
~160
Magnetic Resonance Imaging
2017
Completed Phase 3
~1160
Temozolomide
2010
Completed Phase 3
~1880

Find a Location

Who is running the clinical trial?

Jonsson Comprehensive Cancer CenterLead Sponsor
369 Previous Clinical Trials
29,369 Total Patients Enrolled
18 Trials studying Glioblastoma
490 Patients Enrolled for Glioblastoma
Kunal S PatelPrincipal InvestigatorUCLA / Jonsson Comprehensive Cancer Center
~40 spots leftby Dec 2026
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