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Photodynamic Therapy vs Chemical Peels for Actinic Keratosis

Phase 2
Waitlist Available
Led By Murad Alam, MD
Research Sponsored by Northwestern University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
>18 years of age
Be older than 18 years old
Must not have
Participants who are unable to communicate or cooperate with the investigator due to language problems, poor mental development, or impaired cerebral function are not eligible
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 2-8 weeks after treatments
Awards & highlights
No Placebo-Only Group

Summary

This trial is comparing photodynamic therapy to a combination of Jessner's solution and 35% TCA chemical peels to see which is more effective for treating actinic keratoses.

Who is the study for?
This trial is for adults over 18 in the Chicago area who want to treat actinic keratoses on both upper arms and are in good health. They must understand and sign a consent form. Pregnant or nursing individuals, those with communication issues, or extensive skin conditions like eczema or psoriasis on their arms cannot participate.
What is being tested?
The study compares two treatments for actinic keratosis: photodynamic therapy (PDT) on one arm versus a chemical peel using Jessner's solution and trichloroacetic acid (TCA) on the other arm. Each participant receives both treatments, one on each arm, to see which works better.
What are the potential side effects?
Potential side effects of PDT may include redness, swelling, and discomfort at the treatment site. Chemical peels might cause stinging, redness, peeling, scabbing or changes in skin color.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am older than 18 years.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
Select...
I can communicate and cooperate with my doctor without issues.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~2-8 weeks after treatments
This trial's timeline: 3 weeks for screening, Varies for treatment, and 2-8 weeks after treatments for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Percentage of total AKs cleared

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Active Control
Group I: Chemical PeelsActive Control1 Intervention
One upper arm will be exposed to Jessner's Solution AND 35% Trichloroacetic acid peel
Group II: Photodynamic TherapyActive Control1 Intervention
One upper arm will be exposed to blue light therapy

Find a Location

Who is running the clinical trial?

Northwestern UniversityLead Sponsor
1,645 Previous Clinical Trials
958,534 Total Patients Enrolled
Murad Alam, MDPrincipal InvestigatorNorthwestern University
69 Previous Clinical Trials
2,520 Total Patients Enrolled

Media Library

Chemical Peels (Other) Clinical Trial Eligibility Overview. Trial Name: NCT04429308 — Phase 2
Actinic Keratosis Research Study Groups: Chemical Peels, Photodynamic Therapy
Actinic Keratosis Clinical Trial 2023: Chemical Peels Highlights & Side Effects. Trial Name: NCT04429308 — Phase 2
Chemical Peels (Other) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04429308 — Phase 2
~40 spots leftby Dec 2025
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