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Monoclonal Antibodies

EYP-1901 vs Aflibercept for Age-Related Macular Degeneration (wAMD Trial)

Phase 3
Recruiting
Research Sponsored by EyePoint Pharmaceuticals, Inc.
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 5 years
Awards & highlights
No Placebo-Only Group
Pivotal Trial

Summary

This trial is comparing the effectiveness of a new treatment called EYP-1901 to an existing treatment called Aflibercept.

Who is the study for?
This trial is for individuals with wet Age-Related Macular Degeneration (wAMD), either new or previously treated. Participants must have a certain level of vision, measured by the ETDRS letter score, and if previously treated, they should have had at least two anti-VEGF injections in the past six months.
What is being tested?
The study compares EYP-1901 to Aflibercept over two years to see which is more effective for wAMD. It's a phase 3 trial where participants are randomly assigned treatments and neither they nor the researchers know who gets which treatment (double-masked).
What are the potential side effects?
While specific side effects aren't listed here, both EYP-1901 and Aflibercept can potentially cause eye-related side effects due to their application via injection into the eye.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 5 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 5 years for reporting.

Treatment Details

Side effects data

From 2020 Phase 4 trial • 26 Patients • NCT03022292
4%
Retinal detachment
4%
Myelodysplastic syndrome
4%
Pneumonia
100%
80%
60%
40%
20%
0%
Study treatment Arm
IAI Treatment

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.
Pivotal Trial
The final step before approval, pivotal trials feature drugs that have already shown basic safety & efficacy.

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: EYP-1901 2686 µgExperimental Treatment1 Intervention
EYP-1901
Group II: AfliberceptActive Control1 Intervention
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
EYP-1901
2022
Completed Phase 2
~100

Find a Location

Who is running the clinical trial?

EyePoint Pharmaceuticals, Inc.Lead Sponsor
18 Previous Clinical Trials
2,303 Total Patients Enrolled
~267 spots leftby Oct 2026
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