Stereotactic Radiosurgery for Melanoma Brain Metastases

Recruiting in Palo Alto (17 mi)

Overseen byJing Li

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Phase 2

Waitlist Available

Sponsor: M.D. Anderson Cancer Center

No Placebo Group

Prior Safety Data

Approved in 6 Jurisdictions

Trial Summary

What is the purpose of this trial?This phase II trial studies how well stereotactic radiosurgery works in treating patients with melanoma that has spread to more than 3 places in the brain. Stereotactic radiosurgery is a specialized radiation therapy that delivers a single, high dose of radiation directly to the tumor and may cause less damage to normal tissue.

Eligibility Criteria

This trial is for melanoma patients with more than three brain metastases confirmed by MRI. They must have normal kidney function, blood platelet count, and coagulation levels; be able to pause certain medications around treatment time; and not be pregnant or breastfeeding. Patients previously treated with whole-brain radiotherapy or those with additional cancers are excluded.

Inclusion Criteria

Your platelet count is higher than 50,000.

My melanoma diagnosis was confirmed through tissue examination.

All my cancer lesions can be treated, as confirmed by a radiation oncologist.

+6 more

Exclusion Criteria

I have not had whole brain radiotherapy in the last 3 months.

I do not have cancer spread to the lining of my brain or spinal cord.

You cannot have had an allergic reaction to gadolinium in the past.

+3 more

Participant Groups

The study tests stereotactic radiosurgery's effectiveness on patients with multiple melanoma brain metastases. This precise radiation therapy targets tumors directly in a single high dose, potentially sparing healthy tissue.

1Treatment groups

Experimental Treatment

Group I: Treatment (SRS)Experimental Treatment3 Interventions

Patients undergo SRS on day 1.

Stereotactic Radiosurgery is already approved in European Union, United States, Canada, Japan, China, Switzerland for the following indications:

🇪🇺 Approved in European Union as Stereotactic Radiosurgery for: