Stereotactic Radiosurgery for Brain Metastasis

Recruiting in Palo Alto (17 mi)

Overseen byJing Li

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Phase 2

Waitlist Available

Sponsor: M.D. Anderson Cancer Center

No Placebo Group

Prior Safety Data

Approved in 6 Jurisdictions

Trial Summary

What is the purpose of this trial?

This phase II trial investigates how stereotactic radiosurgery affects brain functions while treating patients with small cell lung cancer that has spread to the brain (brain metastasis). Standard of care treatment consists of whole brain radiation therapy, which targets the entire brain, and may result in side effects affecting the nervous system. Stereotactic radiosurgery only targets areas of the brain that are suspected to be affected by the disease. The purpose of this trial is to learn if and how patients' brain functions are affected by the use of stereotactic radiosurgery rather than whole brain radiation therapy in managing brain metastasis caused by small cell lung cancer. Stereotactic radiosurgery may help patients avoid nervous system side effects caused by whole brain radiation therapy.

Research Team

Jing Li

Principal Investigator

M.D. Anderson Cancer Center

Eligibility Criteria

This trial is for English-speaking patients with small cell lung cancer that has spread to the brain, who have not had prior brain radiation therapy. They must be physically able to participate (ECOG <=3), have 10 or fewer brain metastases, and no history of psychiatric/neurologic illness affecting cognition. Pregnant or breastfeeding women are excluded.

Inclusion Criteria

My doctor has assessed my ability to perform daily activities.

My diagnosis of small cell lung cancer is confirmed through tissue samples.

Patient's primary language is English

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Exclusion Criteria

I do not have a history of metastatic cancer other than small cell, or any uncontrolled non-metastatic cancer.

I do not have a psychiatric or neurological illness affecting my thinking, except if it's due to brain metastasis.

You cannot participate if tests find cancer cells in your spinal fluid.

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Treatment Details

Interventions

Stereotactic Radiosurgery (Radiation Therapy)

Trial OverviewThe trial studies stereotactic radiosurgery's effect on brain function in treating brain metastasis from small cell lung cancer. It compares this targeted approach to standard whole-brain radiation therapy, aiming to reduce nervous system side effects.

Participant Groups

1Treatment groups

Experimental Treatment

Group I: Treatment (SRS)Experimental Treatment2 Interventions

Patients undergo SRS in the absence of disease progression or unacceptable toxicity. Patients whose disease progresses may be treated with additional courses of SRS per physician discretion.

Stereotactic Radiosurgery is already approved in Canada, Japan, China, Switzerland for the following indications: