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local antibiotics and surgery for Gum Disease

Phase 3
Waitlist Available
Led By J Max Goodson, DDS, PhD
Research Sponsored by The Forsyth Institute
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 5 years
Awards & highlights

Summary

The purpose of this study is to test combined effects of scaling and root planing with periodontal surgery, systemically administered amoxicillin and metronidazole, and/or local tetracycline on pocket depth reduction and attachment level "gain" in patients with chronic periodontitis.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 5 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 5 years for reporting.

Treatment Details

Trial Design

8Treatment groups
Experimental Treatment
Active Control
Group I: systemic antibiotics and surgeryExperimental Treatment1 Intervention
Group II: systemic antibioticsExperimental Treatment1 Intervention
Group III: local antibiotics and surgeryExperimental Treatment1 Intervention
Group IV: local antibiotic and systemic antibioticsExperimental Treatment1 Intervention
Group V: local and systemic antibiotics and surgeryExperimental Treatment1 Intervention
Group VI: Periodontal surgeryExperimental Treatment1 Intervention
Group VII: Local delivery of tetracyclineExperimental Treatment1 Intervention
Group VIII: Scaling and root planingActive Control1 Intervention
scaling and root planing as a solo therapy
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Tetracycline
FDA approved
Amoxicillin
FDA approved
Amoxicillin
FDA approved

Find a Location

Who is running the clinical trial?

The Forsyth InstituteLead Sponsor
14 Previous Clinical Trials
1,550 Total Patients Enrolled
Göteborg UniversityOTHER
425 Previous Clinical Trials
1,021,785 Total Patients Enrolled
Boston UniversityOTHER
467 Previous Clinical Trials
9,954,081 Total Patients Enrolled
~7 spots leftby Sep 2025
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