Lidocaine + Epinephrine for Local Anesthesia

Palo Alto (17 mi)

Overseen byKira Minkis, MD, PhD

Age: 18+

Sex: Any

Travel: May be covered

Time Reimbursement: Varies

Trial Phase: Phase 4

Waitlist Available

Sponsor: Weill Medical College of Cornell University

No Placebo Group

Prior Safety Data

Trial Summary

What is the purpose of this trial?This is a research study to compare how long injectable pain medications (anesthetics) commonly used in dermatologic surgery are effective for. The investigators will investigate the role of anesthetic volume on the duration of action at highly vascular sites.

Eligibility Criteria

This trial is for individuals who require local anesthesia, possibly for dermatologic procedures. Specific eligibility criteria are not provided, so it's assumed that participants should be in good health and suitable for receiving local anesthetics.

Exclusion Criteria

I am currently taking MAOI or certain types of antidepressants.

Treatment Details

The study is testing the duration of pain relief from two different volumes of lidocaine mixed with epinephrine (0.5 ml and 1.0 ml) at sites with a lot of blood vessels to see if more anesthetic means longer pain relief.

2Treatment groups

Experimental Treatment

Group I: 1.0 ml Lidocaine with epinephrine vs 0.5 ml Lidocaine with epinephrineExperimental Treatment2 Interventions

Each side of the nasal ala will be tested for normal sensation using sterile 30-gauge needles. Other eligibility criteria will be confirmed. Participants in this arm will receive an injection of 1.0ml of Xylocaine + epinephrine 1:100,000 (lidocaine + epinephrine 1:100,000), buffered 1/10 with sodium bicarb into one side of the nose (nasal ala) and 0.5 ml of Xylocaine + epinephrine 1:100,000 (lidocaine + epinephrine 1:100,000), buffered 1/10 with sodium bicarb into the opposite nasal ala. Laterality of each anesthetic volume administration will be randomly assigned for each patient. Subjects will be evaluated for duration of effect of anesthesia every 15 minutes on both sides of the face, until the patient reports return of a sharp sensation upon the pinprick test.

Group II: 0.5 ml Lidocaine with epinephrine vs. 1.0 ml Lidocaine with epinephrineExperimental Treatment2 Interventions

Each side of the nasal ala will be tested for normal sensation using sterile 30-gauge needles. Other eligibility criteria will be confirmed. Participants in this arm will receive an injection of 0.5ml of Xylocaine + epinephrine 1:100,000 (lidocaine + epinephrine 1:100,000), buffered 1/10 with sodium bicarb into one side of the nose (nasal ala) and 1.0 ml of Xylocaine + epinephrine 1:100,000 (lidocaine + epinephrine 1:100,000), buffered 1/10 with sodium bicarb into the opposite nasal ala. Laterality of each anesthetic volume administration will be randomly assigned for each patient. Subjects will be evaluated for duration of effect of anesthesia every 15 minutes on both sides of the face, until the patient reports return of a sharp sensation upon the pinprick test.