Needle Gauge and Anesthetic for Knee Arthritis Injections

Recruiting in Palo Alto (17 mi)

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Phase 4

Waitlist Available

Sponsor: University of California, Davis

Prior Safety Data

Trial Summary

What is the purpose of this trial?This study aims to investigate factors that affect the subjective experience of pain during and after intra-articular knee joint injection of steroids by comparing needle gauge size (22 G vs 25 G needles), as well as the presence or absence of topical ethyl chloride spray. Additionally, this study will investigate the effects of other various factors on patients' pain associated with the injection. Lastly, this study aims to determine the effect of patients' subjective pain from the injection on long-term clinical outcomes. Specific aims are as follows: Aim 1): Determine the effect of needle gauge size on patient reported pain associated with an ultrasound-guided intra-articular knee injection. Aim 2): Determine the effect of ethyl chloride spray on patient reported pain associated with an ultrasound-guided intra-articular knee injection. Aim 3): Determine the effect of sex, age, BMI, thigh size, severity of OA, and fear of needles on patient pain associated with an ultrasound-guided intra-articular knee injection. Aim 4) Determine the effect of patient pain from the procedure on longer term clinical outcomes after an ultrasound-guided intra-articular knee steroid injection. Researchers will obtain data at various time points, including pre-procedural data, immediately after the procedure, 24-48 hours after, and 6 weeks post-procedure. Participants will: Consent to receiving an intra-articular knee joint injection with steroids if indicated. Score their "procedural" pain immediately following the procedure, score their post-procedural "soreness" 24-48 hours after via telephone call, and score their overall knee pain about 6 weeks after the procedure via telephone call.

Eligibility Criteria

This trial is for individuals with knee osteoarthritis who need steroid injections and are not afraid of needles. It's open to adults regardless of sex, age, BMI, or thigh size. However, it excludes those who can't consent to the procedure or follow-up calls.

Inclusion Criteria

I have agreed to receive a knee injection with steroids.

Fulfillment of the American College of Rheumatology criteria for knee OA

I am 40 years old or older.

+3 more

Exclusion Criteria

I had a knee arthroscopy within the last 6 months.

I have not had a steroid injection in my knee in the last 3 months.

Cognitively impaired individuals

+3 more

Participant Groups

The study tests pain levels during knee injections using different needle sizes (22G vs 25G) and with/without ethyl chloride spray. It also examines how factors like gender, age, body size, arthritis severity affect pain perception and long-term outcomes.

4Treatment groups

Experimental Treatment

Placebo Group

Group I: 25 Gauge Needle WITH Ethyl Chloride sprayExperimental Treatment2 Interventions

This group will receive an intra-articular knee joint injection using a 25 gauge needle, and will be pre-anesthetized with ethyl chloride spray

Group II: 22 Gauge Needle WITH Ethyl Chloride sprayExperimental Treatment2 Interventions

This group will receive an intra-articular knee joint injection using a 22 gauge needle, and will be pre-anesthetized with ethyl chloride spray

Group III: 22 Gauge Needle WITHOUT Ethyl Chloride sprayPlacebo Group2 Interventions

This group will receive an intra-articular knee joint injection using a 22 gauge needle, and will be pre-anesthetized with a PLACEBO spray

Group IV: 25 Gauge Needle WITHOUT Ethyl Chloride sprayPlacebo Group2 Interventions

This group will receive an intra-articular knee joint injection using a 25 gauge needle, and will be pre-anesthetized with a PLACEBO spray