Sympathetic Nervous System Analysis for Coronary Artery Dissection

Recruiting in Palo Alto (17 mi)

Overseen by Marysia Tweet, MD, MS

Age: 18+

Sex: Female

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Recruiting

Sponsor: Mayo Clinic

Must not be taking: Anticoagulants, Antiplatelets

Disqualifiers: Pregnancy, Unstable cardiac, Prisoner, others

No Placebo Group

Trial Summary

What is the purpose of this trial?

This trial compares the stress response and artery health of people who have had a heart artery tear to those who haven't. Researchers will measure how well their body's stress system works and how healthy their arteries are.

Will I have to stop taking my current medications?

The trial does not specify if you need to stop taking your current medications, but you cannot participate if you are actively being treated with anticoagulation (blood thinners) or dual antiplatelet therapy (medications that prevent blood clots).

What data supports the effectiveness of the treatment Sympathetic Nervous System Analysis for Coronary Artery Dissection?

Research shows that the sympathetic nervous system plays a crucial role in regulating circulation and is involved in cardiovascular diseases. Understanding and analyzing this system can help in developing new therapeutic strategies, which may be beneficial for conditions like coronary artery dissection. ^{1 2 3 4 5}

Is the Sympathetic Nervous System Analysis generally safe for humans?

The axillary sympathectomy, a surgical approach to the sympathetic nervous system, is generally safe with a smooth recovery, though some temporary side effects like Horner's Syndrome (drooping eyelid and small pupil), pneumothorax (collapsed lung), and hemothorax (blood in the chest cavity) can occur but are avoidable. ^{1 2 3 6 7}

How does the treatment for coronary artery dissection differ from other treatments?

This treatment focuses on analyzing the sympathetic nervous system (SNS), which is involved in regulating blood flow and heart function. Unlike other treatments that may not directly target the SNS, this approach uses techniques like microneurography to assess and potentially modulate SNS activity, offering a novel way to address the condition. ^{1 5 8 9 10}

Research Team

Marysia Tweet, MD, MS

Principal Investigator

Mayo Clinic

Eligibility Criteria

This study is for individuals with a history of spontaneous coronary artery dissection (SCAD), confirmed by specific heart imaging tests, and healthy volunteers without any cardiac disease. Pregnant women, those with unstable heart conditions recently, or on certain blood thinners can't participate.

Inclusion Criteria

My SCAD diagnosis was confirmed through specific heart imaging tests.

I have never had heart disease.

Exclusion Criteria

I have not had any heart problems in the last month.

Pregnancy

Prisoner

Trial Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Diagnostic Assessment

Participants undergo a series of diagnostic studies to assess neurovascular function

Baseline

Follow-up

Participants are monitored for safety and effectiveness after diagnostic assessments

4 weeks

Treatment Details

Interventions

• Sympathetic Nervous System Analysis (Behavioural Intervention)

Trial Overview The trial investigates the sympathetic nervous system's activity (our body's fight or flight response) and arterial health in SCAD patients compared to healthy people using non-invasive tests like echocardiograms and carotid ultrasounds.

Participant Groups

Group I: Spontaneous coronary artery dissection (SCAD) group Experimental Treatment 6 Interventions

Subject with a history of SCAD will undergo a series of diagnostic studies to assess neurovascular function.

Group II: Healthy Control Group Experimental Treatment 6 Interventions

Healthy subjects will undergo a series of diagnostic studies to assess neurovascular function.

Find a Clinic Near You

Research Locations Nearby Select from list below to view details:

Mayo Clinic Rochester Rochester, MN

Who Is Running the Clinical Trial?

Mayo Clinic

Lead Sponsor

Trials

3427

Patients Recruited

3,221,000+

National Heart, Lung, and Blood Institute (NHLBI)

Collaborator

Trials

3987

Patients Recruited

47,860,000+

Findings from Research

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Axillary sympathectomy for upper extremities. Man, B., Kraus, L., Motovic, A.[2019]

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Branches of the thoracic sympathetic trunk in the human fetus. Groen, GJ., Baljet, B., Boekelaar, AB., et al.[2019]

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Cardiac sympathetic neuroimaging: summary of the First International Symposium. Goldstein, DS., Orimo, S.[2021]

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Topographical considerations under video-scope guidance in the T3,4 levels sympathetic surgery. Kim, DH., Hong, YJ., Hwang, JJ., et al.[2016]

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

[Sympathy and heartache: new information on the sympathetic nervous system]. Spieker, LE., Binggeli, C., Lüscher, TF., et al.[2007]

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

The lumbar sympathetic. Anatomy and surgical implications. Simeone, FA.[2005]

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Blood supply of the human cervical sympathetic chain and ganglia. Tubbs, RS., Salter, G., Wellons, JC., et al.[2019]

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

[Effect of bilateral superior cervical sympathetic ganglion occlusion on pathological process of aortic dissection and its mechanism]. Zhang, Z., Wang, H., Zhang, Y., et al.[2023]

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Anatomical variations of the upper thoracic sympathetic chain: a review. Vanlommel, J., Van Look, L., Peetermans, M., et al.[2022]

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Direct evidence of sympathetic hyperactivity in patients with vasospastic angina. Boudou, N., Despas, F., Rothem, JV., et al.[2020]

References

1. United States pubmed.ncbi.nlm.nih.gov

Axillary sympathectomy for upper extremities. [2019]

2. Germany pubmed.ncbi.nlm.nih.gov

Branches of the thoracic sympathetic trunk in the human fetus. [2019]

3. Germany pubmed.ncbi.nlm.nih.gov

Cardiac sympathetic neuroimaging: summary of the First International Symposium. [2021]

4. Germany pubmed.ncbi.nlm.nih.gov

Topographical considerations under video-scope guidance in the T3,4 levels sympathetic surgery. [2016]

5. Switzerland pubmed.ncbi.nlm.nih.gov

[Sympathy and heartache: new information on the sympathetic nervous system]. [2007]

6. England pubmed.ncbi.nlm.nih.gov

The lumbar sympathetic. Anatomy and surgical implications. [2005]

7. England pubmed.ncbi.nlm.nih.gov

Blood supply of the human cervical sympathetic chain and ganglia. [2019]

8. China pubmed.ncbi.nlm.nih.gov

[Effect of bilateral superior cervical sympathetic ganglion occlusion on pathological process of aortic dissection and its mechanism]. [2023]

9. Germany pubmed.ncbi.nlm.nih.gov

Anatomical variations of the upper thoracic sympathetic chain: a review. [2022]

10. United States pubmed.ncbi.nlm.nih.gov

Direct evidence of sympathetic hyperactivity in patients with vasospastic angina. [2020]