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Cued Picture-Naming Therapy for Aphasia

N/A
Recruiting
Led By Stacy M Harnish, PhD
Research Sponsored by Ohio State University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Native English Speaker.
At least six months post-onset of a single left-hemisphere stroke
Must not have
Severe depression
Diffuse injury or disease of the brain
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 4 months
Awards & highlights
No Placebo-Only Group

Summary

This trial will investigate whether genes and cognitive abilities predict responsiveness to aphasia therapy for word-retrieval difficulties.

Who is the study for?
This trial is for native English speakers who have chronic aphasia, specifically difficulty retrieving words (anomia), due to a single left-hemisphere stroke that occurred at least six months ago. It's not suitable for those with severe comprehension issues, depression, MRI contraindications like pacemakers or metal implants, claustrophobia, pregnancy, severe speech disorders, widespread brain damage or uncorrected vision/hearing problems.
What is being tested?
The study is exploring the effectiveness of cued picture-naming therapy in treating word-retrieval difficulties in people with aphasia. It aims to determine if two specific genes and cognitive abilities such as memory can predict how well someone will respond to this treatment.
What are the potential side effects?
Since the intervention involves non-invasive therapy sessions focused on language recovery rather than medication or surgery, there are no direct physical side effects expected from the cued picture-naming therapy itself.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am a native English speaker.
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It has been over 6 months since my stroke in the left side of my brain.
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I struggle to find the right words when speaking.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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I have severe depression.
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I have widespread brain damage or disease.
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I have vision or hearing problems that haven't been corrected.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~4 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 4 months for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Percent of pictures named correctly
Percentage of pictures named correctly
Secondary study objectives
Percentage of untrained pictures named correctly
percentage of definitions named correctly

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups
Experimental Treatment
Group I: Single Arm TreatmentExperimental Treatment1 Intervention
Cued picture naming therapy will be delivered to all participants. There will be four cohorts of participants based on BDNF and ApoE genotypes.

Find a Location

Who is running the clinical trial?

Ohio State UniversityLead Sponsor
871 Previous Clinical Trials
655,851 Total Patients Enrolled
1 Trials studying Aphasia
20 Patients Enrolled for Aphasia
Nationwide Children's HospitalOTHER
348 Previous Clinical Trials
5,227,690 Total Patients Enrolled
Stacy M Harnish, PhDPrincipal InvestigatorOhio State University

Media Library

Cued picture-naming therapy Clinical Trial Eligibility Overview. Trial Name: NCT05179538 — N/A
Aphasia Research Study Groups: Single Arm Treatment
Aphasia Clinical Trial 2023: Cued picture-naming therapy Highlights & Side Effects. Trial Name: NCT05179538 — N/A
Cued picture-naming therapy 2023 Treatment Timeline for Medical Study. Trial Name: NCT05179538 — N/A
~15 spots leftby Aug 2025
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