Cued Picture-Naming Therapy for Aphasia
Recruiting in Palo Alto (17 mi)
Age: 18+
Sex: Any
Travel: May Be Covered
Time Reimbursement: Varies
Trial Phase: Academic
Recruiting
Sponsor: Ohio State University
Disqualifiers: Severe motor speech, auditory comprehension, depression, others
No Placebo Group
Trial Summary
What is the purpose of this trial?Aphasia, or language impairment after a stroke, affects approximately 2 million people in the United States, with an estimated 180,000 new cases each year. The medical community cannot predict how well someone with aphasia will respond to treatment, as some people with aphasia are poor responders to intervention even when participating in empirically supported treatments. There is a strong likelihood that genetics play a role in language recovery after stroke, but very little research has been dedicated to investigating this link. This study will investigate whether two genes and cognitive abilities, such as memory, predict responsiveness to aphasia therapy for word-retrieval difficulties.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications.
What data supports the effectiveness of the treatment Cued Picture-Naming Therapy for Aphasia?
Research shows that using phonological (sound-related) and semantic (meaning-related) cues can help people with aphasia improve their ability to name pictures. Studies have found that these cueing strategies can make naming faster and more accurate, suggesting they are effective components of the treatment.
12345Is Cued Picture-Naming Therapy safe for humans?
The research articles do not report any safety concerns related to Cued Picture-Naming Therapy for individuals with aphasia, suggesting it is generally safe for use in humans.
12367How is cued picture-naming therapy different from other treatments for aphasia?
Cued picture-naming therapy is unique because it uses both semantic (meaning-based) and phonological (sound-based) cues to help people with aphasia improve their ability to name objects. This approach combines different types of cues to enhance the retrieval of words, making it potentially more effective than treatments that use only one type of cue.
12357Eligibility Criteria
This trial is for native English speakers who have chronic aphasia, specifically difficulty retrieving words (anomia), due to a single left-hemisphere stroke that occurred at least six months ago. It's not suitable for those with severe comprehension issues, depression, MRI contraindications like pacemakers or metal implants, claustrophobia, pregnancy, severe speech disorders, widespread brain damage or uncorrected vision/hearing problems.Inclusion Criteria
I am a native English speaker.
It has been over 6 months since my stroke in the left side of my brain.
I struggle to find the right words when speaking.
+1 more
Exclusion Criteria
You have a serious difficulty understanding spoken language.
Contraindications for MRI (e.g. cardiac pacemaker, ferrous metal implants, claustrophobia, pregnancy).
You have a serious difficulty speaking clearly.
+3 more
Trial Timeline
Screening
Participants are screened for eligibility to participate in the trial
2-4 weeks
Cognitive and Genetic Assessment
Participants undergo cognitive and language assessment and provide a saliva sample for genetic analysis
1-2 weeks
1 visit (in-person)
Treatment
Cued picture naming therapy is delivered to all participants
4 weeks
4 visits (in-person)
Follow-up
Participants are monitored for changes in picture-naming scores from post-treatment to follow-up
4 months
2 visits (in-person)
Participant Groups
The study is exploring the effectiveness of cued picture-naming therapy in treating word-retrieval difficulties in people with aphasia. It aims to determine if two specific genes and cognitive abilities such as memory can predict how well someone will respond to this treatment.
1Treatment groups
Experimental Treatment
Group I: Single Arm TreatmentExperimental Treatment1 Intervention
Cued picture naming therapy will be delivered to all participants. There will be four cohorts of participants based on BDNF and ApoE genotypes.
Find a Clinic Near You
Research Locations NearbySelect from list below to view details:
The Ohio State UniversityColumbus, OH
Loading ...
Who Is Running the Clinical Trial?
Ohio State UniversityLead Sponsor
Nationwide Children's HospitalCollaborator
References
The effects of single versus combined cue presentations on picture naming by aphasic adults. [2019]Research has demonstrated that the presentation of auditory and visual cues is an effective clinical procedure for improving picture naming of nonfluent aphasic speakers. The effect of combined cue presentation, however, has not been clearly demonstrated. The present study investigated the effect of single and multiple cueing techniques used with nonfluent (Broca's) aphasic patients. The subjects were divided into a minimum or maximum error group based on their performance on a picture-naming task. Printed words (in either cursive or manuscript style), initial syllables, and sentence completion cues were presented independently and in combination. Discussion is directed toward the potential clinical application of multiple cueing techniques.
What Does a Cue Do? Comparing Phonological and Semantic Cues for Picture Naming in Aphasia. [2019]Impaired naming is one of the most common symptoms in aphasia, often treated with cued picture naming paradigms. It has been argued that semantic cues facilitate the reliable categorization of the picture, and phonological cues facilitate the retrieval of target phonology. To test these hypotheses, we compared the effectiveness of phonological and semantic cues in picture naming for a group of individuals with aphasia. To establish the locus of effective cueing, we also tested whether cue type interacted with lexical and image properties of the targets.
Effects of two lexical retrieval cueing treatments on action naming in aphasia. [2009]The effects of two cueing treatments, Phonological Cueing Treatment (PCT) and Semantic Cueing Treatment (SCT), were examined with three chronic speakers with aphasia. The effects of treatment on action naming were measured with the use of single-subject experimental designs. The participants had received PCT and SCT to improve object naming in a previous investigation and had responded positively to both treatments. In the current study, Speaker 1 received SCT, Speaker 2 received PCT, and Speaker 3 received both SCT and PCT. Action naming improved for Speakers 1 and 3, but not for Speaker 2. These findings indicate that PCT and SCT may have utility in facilitating action naming for some speakers with aphasia but that the effects of these treatments may vary across grammatical form classes (e.g., nouns versus verbs).
Phonological and orthographic approaches to the treatment of word retrieval in aphasia. [2019]We present a preliminary report on a study of the treatment of word finding difficulties in aphasia using phonological and orthographic cues. These techniques although often used to cue word finding in the immediate term have been little evaluated in terms of therapy designed to improve word retrieval in the long term. The first phase using cued word retrieval in a picture naming task was followed by a second phase designed to facilitate use of treated words in real-life contexts. The results from both phases were encouraging with improved word retrieval for three out of the four participants. The implications for clinical practice are discussed.
Multisensory cueing facilitates naming in aphasia. [2020]Impaired naming is a ubiquitous symptom in all types of aphasia, which often adversely impacts independence, quality of life, and recovery of affected individuals. Previous research has demonstrated that naming can be facilitated by phonological and semantic cueing strategies that are largely incorporated into the treatment of anomic disturbances. Beneficial effects of cueing, whereby naming becomes faster and more accurate, are often attributed to the priming mechanisms occurring within the distributed language network.
Treatment of word retrieval deficits in aphasia. A comparison of two therapy methods. [2006]The effects of two therapy methods in the treatment of picture naming problems are compared, using a within-patient design with 12 adult patients with chronic acquired aphasia. We contrast techniques that require the patient to process the meaning corresponding to the picture name (semantic treatment) with those that provide the patients with information about the phonological form of the name (phonological treatment). With each method, patients either had 4 sessions of treatment over one week, or 8 sessions over two weeks. Both methods caused day-by-day improvement that was specific to the actual items treated. Both methods resulted in significant improvement in naming when this was measured one week after the end of treatment, with a small, but significant advantage for the semantic treatment; this is mainly due to improvement that generalizes to untreated items. We conclude that specific and theoretically motivated treatment methods can cause significant improvement in the word retrieval ability of patients with chronic aphasia.
Effect of auditory prestimulation on naming in aphasia. [2019]In five aphasic subjects, picture naming alone was compared with picture naming in the presence of four different auditory cues. Eighty words represented by pictures were associated with the following auditory cues: the first phoneme of the target word; an open-ended sentence designed to elicit the target word; three words, one of which was the target word; three words, all semantically related to the target word. Three conditions--the phonetic cue, the open-ended sentence, and the set of three words containing the target word--facilitated naming significantly. The condition making use of semantically related words resulted in a significant decrease in naming performance. Implications of these findings for theories of verbal recall, impairment of verbal recall in aphasia, and language therapy are discussed.