← Back to Search

Behavioural Intervention

Combined Exercise and Therapy for Post-Stroke Reading Deficits

N/A

Recruiting

Led By Olga Boukrina

Research Sponsored by Kessler Foundation

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

1st ever stroke

Summary

This trial aims to test a new way of treating reading disorders caused by stroke. It will combine exercise training with a specific reading treatment to help improve blood flow in the brain and strengthen the damaged neural networks

Who is the study for?

This trial is for right-handed individuals who were fluent in English and literate before their first-ever stroke, which occurred over 3 months ago. They must have reading deficits as defined by specific accuracy percentages for words and nonwords, be cleared for exercise by a physician, and live within 50 miles of the Kessler Foundation. People with MRI contraindications, prior neurological diseases, or those currently undergoing speech therapy cannot participate.

What is being tested?

The study tests a new treatment method combining physical exercises (stretching and aerobic training) with Phono-Motor Therapy to improve reading abilities after a stroke. The goal is to boost brain circulation and repair damaged language networks through this dual approach.

What are the potential side effects?

While the trial's description does not specify side effects, typical ones from exercise may include muscle soreness or fatigue. Phono-Motor Therapy generally doesn't have physical side effects but can sometimes cause frustration or mental fatigue.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I have had my first stroke.

Select...

It has been over 3 months since I had a stroke.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

Select...

I have had a neurological disease before.

Select...

I am currently receiving speech and language therapy.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline and within 2 weeks of treatment completion (~10 weeks from study onset)

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline and within 2 weeks of treatment completion (~10 weeks from study onset)

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline and within 2 weeks of treatment completion (~10 weeks from study onset) for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

2 Alternative Forced Choice Computer Tasks

Cerebral Blood Flow (CBF)

Reading Aloud

+3 more

Secondary study objectives

Philadelphia Naming Test (Short)

Western Aphasia Battery Revised

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: Aerobic Exercise Treatment (AET) combined with Phono-Motor Therapy (PMT)Experimental Treatment2 Interventions

Patients will receive 40, once-daily 2-hour intervention sessions administered 4-5 times per week by trained research assistants. Sessions will begin with a 5-min warm-up, followed by 20 min of aerobic exercise (cycling, 60% heart rate range), and a 5-min cool-down. Participants will rate their perceived effort every 5 minutes and complete a log at the end of each session to characterize their experience. When HR returns to near resting levels (i.e., 5-min after cool-down), participants will undertake the PMT for the remaining 90 min.

Group II: Stretching and PMTActive Control2 Interventions

Patients will receive 40, once-daily 2-hour intervention sessions administered 4-5 times per week by trained research assistants. Sessions will begin with a 5-min warm-up, followed by 20 min of stretching and a 5-min cool-down. Stretching activities will target the head/neck, shoulder, elbow/forearm, hand/wrist, trunk/hip, ankle/foot. Participants will complete a log at the end of each session to characterize their experience, and within 5 min of completing the last stretching activity, participants will undertake PMT for the remaining 90 min of a given session.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Aerobic Exercise Training (AET)

2015

N/A

~50

0 / 4Eligibility criteria met