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tDCS

Active tDCS plus Speech-Language Therapy for Primary Progressive Aphasia

N/A
Waitlist Available
Led By Argye E Hillis, MD, MS
Research Sponsored by Johns Hopkins University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline, and 4-7 weeks after treatment begins
Awards & highlights

Study Summary

This trial investigates whether tDCS paired with language therapy can help improve verb usage for people with PPA, a debilitating disorder that gradually robs patients of their language skills.

Eligible Conditions
  • Primary Progressive Aphasia

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline, and 4-7 weeks after treatment begins
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, and 4-7 weeks after treatment begins for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in Accuracy of Naming Trained Verbs (0 to 15, Higher Scores Reflect Better Naming Abilities) as Assessed by Object and Action Naming Battery (OANB)
Secondary outcome measures
Change in Accuracy of Naming Trained Verbs (0 to 15, Higher Scores Reflect Better Naming Abilities) as Assessed by Object and Action Naming Battery
Change in Accuracy of Naming Untrained Verbs (0 to 85, Higher Scores Reflect Better Naming Abilities) and Nouns (0 to 162, Higher Scores Reflect Better Naming Abilities) as Assessed by Object and Action Naming Battery
Change in Accuracy of Naming Untrained Verbs (0 to 85, Higher Scores Reflect Better Naming Abilities) and Untrained Nouns (0 to 162, Higher Scores Reflect Better Naming Abilities) as Assessed by Object and Action Naming Battery
+1 more

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Active tDCS plus Speech-Language TherapyExperimental Treatment2 Interventions
Active tDCS will be applied at the beginning of 45min speech-language therapy session and will last for 20 min. Language therapy will be verb naming therapy in a sentence context. This will be followed by sham tDCS plus speech-language therapy after a 2 month washout period.
Group II: Sham plus Speech-Language TherapyPlacebo Group2 Interventions
Sham tDCS will be applied at the beginning of 45min speech-language therapy session. Language therapy will be oral and written naming. Language therapy will be verb naming therapy in a sentence context. This will be followed by active tDCS plus speech-language therapy after a 2 month washout period.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Active tDCS plus Speech-Language Therapy
2018
N/A
~10
Sham tDCS plus Speech-Language Therapy
2018
N/A
~10

Find a Location

Who is running the clinical trial?

Johns Hopkins UniversityLead Sponsor
2,274 Previous Clinical Trials
14,840,510 Total Patients Enrolled
Argye E Hillis, MD, MSPrincipal InvestigatorJohns Hopkins University
Shannon M Sheppard, PhDPrincipal InvestigatorJohns Hopkins University
~1 spots leftby Jun 2025
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