Alkylating agents
Chemotherapy + Bevacizumab for Abdominal Cancer
This trial is testing a new cancer treatment combining two drugs, one given directly into the abdomen and one taken by mouth. It is for people with a certain kind of cancer that has spread into the abdomen, and who have had surgery to remove as much of the cancer as possible.
CAR T-cell Therapy
Gene-Modified T Cells for Advanced Cancers
This trial is testing the side effects and best dose of gene-modified T cells, given with or without decitabine, to treat patients with malignancies expressing cancer-testis antigens 1 (NY-ESO-1) gene that have spread to other places in the body (advanced).
Popular Filters
Trials for Ovarian Tumors Patients
CAR T-cell Therapy
ICT Cell Therapy for Ovarian Cancer
This trial tests a new treatment using modified immune cells (AB-1015) for patients with ovarian cancer that didn't respond to standard treatments. The modified cells are designed to target and kill cancer cells. The goal is to find a safe dose and see if the treatment helps fight the cancer. Modified immune cells, such as those used in AB-1015, have shown good curative effects in treating ovarian cancer.
Monoclonal Antibodies
SGN-B7H4V for Advanced Cancers
This trial tests a new drug called SGN-B7H4V for safety and side effects in patients with advanced or metastatic solid tumors. It aims to find the right dosage and see if the drug can effectively treat their cancer.
Cancer Vaccine
Oregovomab + Chemo for Advanced Ovarian Cancer
This trial tests if oregovomab, an IV medication, can help treat advanced ovarian cancer when used with standard chemotherapy. It targets patients who have had surgery to remove tumors and aims to boost the immune system to fight cancer cells more effectively. Oregovomab has been previously tested in advanced ovarian cancer but did not improve outcomes.
Chemotherapy
Chemotherapy + Pembrolizumab/Olaparib for Ovarian Cancer
This trial is testing a new combination of drugs to treat ovarian cancer. The new combination is pembrolizumab, carboplatin/paclitaxel, and maintenance olaparib. The hypothesis is that this new combination will be better than just carboplatin/paclitaxel at treating ovarian cancer.
PARP Inhibitor
PARP Inhibitor + CTLA-4 Blockade for Ovarian Cancer
This trial is testing a combination of two drugs to treat ovarian cancer that is caused by a BRCA mutation. The drugs are a PARP inhibitor and a T cell checkpoint inhibitor. The trial is testing to see if this combination is safe and effective.
Trials for Ovarian Cancer Patients
CAR T-cell Therapy
ICT Cell Therapy for Ovarian Cancer
This trial tests a new treatment using modified immune cells (AB-1015) for patients with ovarian cancer that didn't respond to standard treatments. The modified cells are designed to target and kill cancer cells. The goal is to find a safe dose and see if the treatment helps fight the cancer. Modified immune cells, such as those used in AB-1015, have shown good curative effects in treating ovarian cancer.
Monoclonal Antibodies
SGN-B7H4V for Advanced Cancers
This trial tests a new drug called SGN-B7H4V for safety and side effects in patients with advanced or metastatic solid tumors. It aims to find the right dosage and see if the drug can effectively treat their cancer.
Cancer Vaccine
Oregovomab + Chemo for Advanced Ovarian Cancer
This trial tests if oregovomab, an IV medication, can help treat advanced ovarian cancer when used with standard chemotherapy. It targets patients who have had surgery to remove tumors and aims to boost the immune system to fight cancer cells more effectively. Oregovomab has been previously tested in advanced ovarian cancer but did not improve outcomes.
Chemotherapy
Chemotherapy + Pembrolizumab/Olaparib for Ovarian Cancer
This trial is testing a new combination of drugs to treat ovarian cancer. The new combination is pembrolizumab, carboplatin/paclitaxel, and maintenance olaparib. The hypothesis is that this new combination will be better than just carboplatin/paclitaxel at treating ovarian cancer.
PARP Inhibitor
PARP Inhibitor + CTLA-4 Blockade for Ovarian Cancer
This trial is testing a combination of two drugs to treat ovarian cancer that is caused by a BRCA mutation. The drugs are a PARP inhibitor and a T cell checkpoint inhibitor. The trial is testing to see if this combination is safe and effective.
Trials for BRCA1 Positive Patients
CAR T-cell Therapy
ICT Cell Therapy for Ovarian Cancer
This trial tests a new treatment using modified immune cells (AB-1015) for patients with ovarian cancer that didn't respond to standard treatments. The modified cells are designed to target and kill cancer cells. The goal is to find a safe dose and see if the treatment helps fight the cancer. Modified immune cells, such as those used in AB-1015, have shown good curative effects in treating ovarian cancer.
Chemotherapy
Chemotherapy + Pembrolizumab/Olaparib for Ovarian Cancer
This trial is testing a new combination of drugs to treat ovarian cancer. The new combination is pembrolizumab, carboplatin/paclitaxel, and maintenance olaparib. The hypothesis is that this new combination will be better than just carboplatin/paclitaxel at treating ovarian cancer.
PARP Inhibitor
PARP Inhibitor + CTLA-4 Blockade for Ovarian Cancer
This trial is testing a combination of two drugs to treat ovarian cancer that is caused by a BRCA mutation. The drugs are a PARP inhibitor and a T cell checkpoint inhibitor. The trial is testing to see if this combination is safe and effective.
PARP Inhibitor
Niraparib + Dostarlimab for Cancer
This trial is testing the combination of two drugs to treat patients with BRCA-mutated cancer. Niraparib is an inhibitor of PARP, an enzyme that helps repair DNA. TSR-042 is an immunotherapy that may help the body's immune system attack the cancer.
PARP Inhibitor
ZEN003694 + Talazoparib for Ovarian Cancer
This trial is testing a combination of two oral drugs, ZEN003694 and talazoparib, in patients with recurrent ovarian, fallopian tube, or primary peritoneal cancer. ZEN003694 helps stop cancer cells from growing, while talazoparib blocks an enzyme that cancer cells need to repair themselves. The goal is to see how well these drugs work together in this specific group of patients.
Phase 3 Trials
Corticosteroid
Relacorilant + Nab-Paclitaxel for Ovarian Cancer
This trial tests a new combination of two drugs for ovarian cancer patients who have no other treatment options left. The combination includes a drug that may make chemotherapy more effective and a chemotherapy drug that has been used in various cancer treatments. The goal is to see if this combination can help patients live longer without their disease getting worse.
Cancer Vaccine
Oregovomab + Chemo for Advanced Ovarian Cancer
This trial tests if oregovomab, an IV medication, can help treat advanced ovarian cancer when used with standard chemotherapy. It targets patients who have had surgery to remove tumors and aims to boost the immune system to fight cancer cells more effectively. Oregovomab has been previously tested in advanced ovarian cancer but did not improve outcomes.
Chemotherapy
Chemotherapy + Pembrolizumab/Olaparib for Ovarian Cancer
This trial is testing a new combination of drugs to treat ovarian cancer. The new combination is pembrolizumab, carboplatin/paclitaxel, and maintenance olaparib. The hypothesis is that this new combination will be better than just carboplatin/paclitaxel at treating ovarian cancer.
Aromatase Inhibitor
Letrozole +/- Chemotherapy for Ovarian Cancer
This trial is testing whether Letrozole, with or without Paclitaxel and Carboplatin, can effectively treat patients with Stage II-IV Low-Grade Serous Carcinoma of the ovary, fallopian tube, or peritoneum.
Procedure
Minimally Invasive Surgery vs Laparotomy After Chemotherapy for Ovarian and Related Cancers
This trial is comparing two different surgeries for ovarian, primary peritoneal, or fallopian tube cancer patients who are also receiving chemotherapy. One surgery is minimally invasive and the other is laparotomy. They are checking to see if the minimally invasive surgery is just as good or better than the laparotomy in prolonging the return of the disease and/or improving quality of life after surgery.
Trials With No Placebo
CAR T-cell Therapy
ICT Cell Therapy for Ovarian Cancer
This trial tests a new treatment using modified immune cells (AB-1015) for patients with ovarian cancer that didn't respond to standard treatments. The modified cells are designed to target and kill cancer cells. The goal is to find a safe dose and see if the treatment helps fight the cancer. Modified immune cells, such as those used in AB-1015, have shown good curative effects in treating ovarian cancer.
Corticosteroid
Relacorilant + Nab-Paclitaxel for Ovarian Cancer
This trial tests a new combination of two drugs for ovarian cancer patients who have no other treatment options left. The combination includes a drug that may make chemotherapy more effective and a chemotherapy drug that has been used in various cancer treatments. The goal is to see if this combination can help patients live longer without their disease getting worse.
Monoclonal Antibodies
SGN-B7H4V for Advanced Cancers
This trial tests a new drug called SGN-B7H4V for safety and side effects in patients with advanced or metastatic solid tumors. It aims to find the right dosage and see if the drug can effectively treat their cancer.
PARP Inhibitor
PARP Inhibitor + CTLA-4 Blockade for Ovarian Cancer
This trial is testing a combination of two drugs to treat ovarian cancer that is caused by a BRCA mutation. The drugs are a PARP inhibitor and a T cell checkpoint inhibitor. The trial is testing to see if this combination is safe and effective.
View More Related Trials
Frequently Asked Questions
Introduction to peritoneal carcinomatosis
What are the top hospitals conducting peritoneal carcinomatosis research?
Peritoneal carcinomatosis, a condition characterized by the spread of cancer cells to the lining of the abdominal cavity, demands innovative approaches and dedicated research. In Houston's M D Anderson Cancer Center, an esteemed institution renowned for its expertise in oncology, researchers are currently conducting 10 active peritoneal carcinomatosis trials. With a commendable track record of 24 completed trials since their first recorded investigation in 2005, this center leads the way in advancing our understanding and treatment options for this challenging disease.
The National Institutes of Health Clinical Center located in Bethesda is another prominent player in peritoneal carcinomatosis research. Despite having fewer ongoing trials compared to other institutions on this list with four active studies, they have made significant contributions over time with six previous investigations dating back to their initiation into peritoneal carcinomatosis trials also during 2005.
Out on the west coast, Kaiser Permanente Los Angeles Medical Center joins forces with four current peritoneal carcinomatosis clinical trials as part of their commitment to fighting against this devastating condition. Their dedication extends further through eight past investigations that have paved the way for progress since they embarked upon exploring potential solutions more than two decades ago—specifically from1992.
Venturing inland to Tucson's University of Arizona Cancer Center-North Campus reveals another hub for cutting-edge research. With four ongoing peritoneal carcinomatosis studies and seven accomplished trial initiatives since commencing exploration into this area during2009; these ardent researchers contribute significantly towards improving treatment outcomes for patients diagnosed with this formidable disease.
Rounding out our list is Providence Saint Joseph Medical Center/Disney Family Cancer Center situated in Burbank—a hospital not only associated with entertainment but also dedicated to making strides against cancer through dedicated clinical research efforts. Although they too encompass four active peritoneal carcinoma clinical experiments presently underway; interestingly enough theirs stretch beyond shorter span reaching up until ten years earlier when they initiated their earliest peritoneal carcinomatosis trial in 1992.
These leading hospitals, scattered across the United States, represent beacons of hope for patients battling peritoneal carcinomatosis. Their unwavering commitment to research and clinical trials is propelling us closer to breakthroughs that can improve outcomes and quality of life for those affected by this challenging condition.
Which are the best cities for peritoneal carcinomatosis clinical trials?
When it comes to peritoneal carcinomatosis clinical trials, several cities in the United States are at the forefront of research and innovation. Denver, Colorado leads with 20 active trials exploring treatments like Paclitaxel, Quality-of-Life Assessment, and SGN-B7H4V. Houston, Texas closely follows with 18 ongoing studies focused on Adavosertib, Paclitaxel, and Chemotherapy interventions. Anchorage, Alaska is also a notable city with 16 active trials investigating Letrozole, Quality-of-Life Assessment, and Paclitaxel as potential treatment options. Additionally, Tucson in Arizona has 14 active trials studying Paclitaxel and Letrozole among other interventions. Lastly Sacramento in California offers 13 active trials examining treatments such as Paclitaxel, Letrozole,and Oregovomab for peritoneal carcinomatosis patients. These cities provide valuable opportunities for individuals seeking participation in cutting-edge clinical research that may lead to improved outcomes against this challenging condition.
Which are the top treatments for peritoneal carcinomatosis being explored in clinical trials?
Peritoneal carcinomatosis, a challenging condition to treat, has seen notable advancements in clinical trials for various treatments. Paclitaxel emerges as a frontrunner with six active trials and an impressive 40 all-time studies dedicated to peritoneal carcinomatosis since its introduction in 2002. Close behind is cisplatin, currently being explored in three ongoing trials and having recorded 16 total peritoneal carcinomatosis studies since 2009. Additionally, pharmacological studies are gaining traction with two active trials and five overall research endeavors dating back to 2011. Quality-of-life assessment also enters the picture with two active trials and a portfolio of 20 past investigations starting from as early as 2005. Finally, chemotherapy shows promise through two current clinical trials alongside five historical studies beginning in 2012—a testament to the tireless efforts towards improving outcomes for patients battling peritoneal carcinomatosis
What are the most recent clinical trials for peritoneal carcinomatosis?
Exciting developments are occurring in the field of peritoneal carcinomatosis treatment, with recent clinical trials offering new hope for patients. The mEPIC trial, a Phase 2 study, explores innovative approaches to combat this condition and became available on 7/1/2023. Additionally, another trial investigates the potential benefits of combining IP FT538 and Enoblituzumab in treating peritoneal carcinomatosis—a Phase 1 study that became available on 4/28/2023. Furthermore, a compelling experimental approach involving chemotherapy combined with BEV and IMNN-001 is being evaluated through both Phase 1 and Phase 2 trials since becoming available on 2/10/2023. These groundbreaking studies pave the way towards enhanced treatments for peritoneal carcinomatosis patients who can now anticipate improved outcomes in their battle against this challenging disease.
What peritoneal carcinomatosis clinical trials were recently completed?
Recently completed clinical trials for peritoneal carcinomatosis have made significant strides in the search for improved treatments. In November 2021, OncoNano Medicine successfully concluded a trial investigating pegsitacianine as a potential therapy. Additionally, research led by Dan Blazer III, M.D., yielded insights into the effectiveness of Talimogene Laherparepvec, with their trial wrapping up in May 2019. These studies build upon earlier investigations such as Atezolizumab and Rucaparib trials sponsored by Hoffmann-La Roche and Clovis Oncology respectively (both completed in March 2017), along with Hyperthermic Intraperitoneal Chemotherapy (completed in September 2016) conducted at M.D. Anderson Cancer Center, Oxaliplatin research supported by University of Massachusetts Worcester (completed July 2016), and Adavosertib study sponsored by AstraZeneca (concluded January 2015). Collectively these endeavors highlight the ongoing commitment to advancing treatment options for patients grappling with peritoneal carcinomatosis.