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Understanding Immune Cell Response in Asthma

N/A

Recruiting

Led By Andrew D Luster

Research Sponsored by Andrew D. Luster, M.D.,Ph.D.

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Age between 18 and 55 years.

Life-long absence of cigarette smoking (lifetime total of < 5 pack-years and none in 5 years).

Must not have

A history of asthma-related respiratory failure requiring intubation.

Women of childbearing potential who are pregnant (based on urine beta-HCG testing), are sexually active and not using contraception, are seeking to become pregnant or who are nursing.

Timeline

Screening 3 weeks

Treatment Varies

Follow Up this is a single time point study with all information obtained at the time of bronchoscopy defined as day 0.

Awards & highlights

No Placebo-Only Group

Summary

This trial is studying how well memory T helper type 2 cells work to initiate a recall response to aeroallergens in the lungs.

Who is the study for?

This trial is for adults aged 18-55 with allergic asthma, who've never smoked much (less than 5 pack-years and none in the past 5 years), have a certain level of lung function, react to indoor allergens like pet dander or dust mites, and are not pregnant or nursing. People can't join if they're on certain medications, have other lung diseases, severe allergies to specific drugs used in the study, recent infections or steroid use.

What is being tested?

The study investigates how memory Th2 cells in the lungs respond to common airborne allergens by performing bronchoscopy/BAL and airway brushing on participants. It aims to understand these cells' role in allergic reactions which could lead to new treatments for allergic asthma.

What are the potential side effects?

Potential side effects from procedures may include discomfort during bronchoscopy such as coughing or wheezing; sore throat; bleeding; infection risk; reaction to sedatives like fentanyl or midazolam used during the procedure.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am between 18 and 55 years old.

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I have smoked less than 5 packs of cigarettes in my life and none in the last 5 years.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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I have been intubated due to severe asthma in the past.

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I am not pregnant, trying to get pregnant, or nursing, and I use contraception if sexually active.

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I have diabetes, heart failure, arrhythmias, stroke history, kidney failure, severe allergies, or liver cirrhosis.

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I haven't used specific asthma or other condition treatments like Nucala, Cinqair, Fasenra, or Dupixent in the last 6 months.

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I haven't smoked cigarettes in the last 5 years and have smoked less than 5 pack-years in total.

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I do not have other lung conditions like sarcoidosis or active infections.

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I have not used Xolair in the last 6 months.

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I am currently taking beta-blockers or MAO inhibitors.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ this is a single time point study with all information obtained at the time of bronchoscopy defined as day 0.

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~this is a single time point study with all information obtained at the time of bronchoscopy defined as day 0.

This trial's timeline: 3 weeks for screening, Varies for treatment, and this is a single time point study with all information obtained at the time of bronchoscopy defined as day 0. for reporting.