MicroRNA-210 Regulation for Peripheral Arterial Disease

Recruiting in Palo Alto (17 mi)

+3 other locations

Overseen byPanagiotis Koutakis, PhD

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: University of West Florida

No Placebo Group

Trial Summary

What is the purpose of this trial?MicroRNA-210 (miR-210) can be a potential therapeutic target of patients with peripheral artery disease (PAD). Recent evidence suggests the role of miR-210 and oxidative stress in the pathophysiology of PAD and its association with mitochondrial function, oxidative metabolism, walking distances and quality of life. The protocol evaluates the mechanisms which miR-210 regulates oxidative stress and provides evidence of potential therapeutic strategies.

Eligibility Criteria

This trial is for men and women over 30 with peripheral artery disease (PAD) who have severe limb pain or wounds due to poor blood flow, and are candidates for a revascularization operation. They must not have musculoskeletal or neurological symptoms that could affect the study, be willing to follow the study plan, attend check-ups, complete assessments, and give written consent. People undergoing chemotherapy or radiation therapy, those with a life expectancy under 2 years from non-PAD causes, or recent acute lower limb ischemic events can't participate.

Inclusion Criteria

Willingness to comply with protocol, attend follow-up appointments, complete all study assessments, and provide written informed consent

I am 30 years old or older.

I have severe leg pain or non-healing wounds due to poor blood flow.

+3 more

Exclusion Criteria

I recently had a blood clot or injury affecting my leg.

I am expected to live less than 2 years because of conditions not related to PAD.

I am currently undergoing chemotherapy or radiation therapy.

Participant Groups

The trial is studying how microRNA-210 affects oxidative stress in PAD patients. It's looking at whether targeting miR-210 can improve mitochondrial function and quality of life by comparing two groups: one receiving standard care and another undergoing a revascularization operation designed to restore proper blood flow in affected limbs.

2Treatment groups

Experimental Treatment

Group I: Revascularization groupExperimental Treatment1 Intervention

Participants will be randomized to either an endovascular or an open bypass procedure.

Group II: Control groupExperimental Treatment1 Intervention

Healthy non-PAD participants will be recruited as control group