TTFields for Brain Cancer

N/A

Recruiting

Led By Sanjeev Chawla, PhD

Research Sponsored by Abramson Cancer Center of the University of Pennsylvania

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Adult population ≥ 22 years

Histologically confirmed diagnosis of GBM or molecular GBM according to c-IMPACT NOW criteria

Must not have

Presence of infra-tentorial GBM

Presence of significant hemorrhage in and around the tumor bed that may potentially degrade the image quality

Timeline

Screening 3 weeks

Treatment Varies

Follow Up through study completion and clinical follow ups for up to 5 years

Awards & highlights

No Placebo-Only Group

Summary

This trialis testing a novel electrical therapy to treat brain tumors, using MRI to find where to direct the dose, to maximize effectiveness and improve survival & quality of life.

Who is the study for?

This trial is for adults over 22 with a confirmed diagnosis of Glioblastoma (GBM) who've had surgery and radiation therapy. They must have good blood, liver, and kidney function and be willing to receive TTFields treatment. It's not for those with GBM below the cerebellum, pregnant women, people with certain medical devices or skull defects, or sensitivity to conductive hydrogels.

What is being tested?

The study tests if an advanced MRI technique called 'whole brain spectroscopy' can better guide the placement of TTFields therapy compared to standard mapping. This could potentially improve survival rates and quality of life by more effectively targeting tumor cells in GBM patients.

What are the potential side effects?

While specific side effects are not listed for this trial, TTFields therapy may cause skin irritation under the device electrodes, headaches, malaise or muscle twitching. The precise side effects will depend on individual patient responses.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am 22 years old or older.

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My diagnosis of brain cancer is confirmed by lab tests.

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I am willing to undergo TTFields therapy.

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My cancer has specific genetic features (MGMT or IDH).

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I've had surgery to remove as much of the tumor as safely possible, followed by a specific course of radiation.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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My brain tumor is located below the tentorium.

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I have bleeding in the area of my tumor that could affect imaging tests.

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I have health issues that would prevent me from taking TMZ treatment.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ through study completion and clinical follow ups for up to 5 years

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~through study completion and clinical follow ups for up to 5 years

This trial's timeline: 3 weeks for screening, Varies for treatment, and through study completion and clinical follow ups for up to 5 years for reporting.