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Early Brain Surgery for Brain Tumor

N/A
Recruiting
Led By Terence C Burns
Research Sponsored by Mayo Clinic
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Histological or cytological confirmation of brain tumor and/or suspected brain tumor based on clinical and radiologic findings
Age >= 18 years
Must not have
Avastin within the past 6 months for any reason
Age < 18 years
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 5 years
Awards & highlights
No Placebo-Only Group

Summary

This trial is testing whether surgery on brain tumors before they come back is more effective than surgery at a different time or no surgery.

Who is the study for?
This trial is for adults over 18 who've had chemo or radiation for brain tumors but still have some tumor left. They must be willing to undergo surgery, not be pregnant or unable to consent, and can't have had a complete tumor removal before. They should also not qualify for other clinical trials.
What is being tested?
The study looks at the timing of brain surgery in treating tumors that haven't recurred yet. It compares outcomes between those having early surgery after chemo/radiation and those who wait or don’t get operated on at all.
What are the potential side effects?
Potential side effects include typical risks associated with brain surgery such as infection, bleeding, neurological damage, reaction to anesthesia, and complications from wound healing.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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My brain tumor diagnosis was confirmed through lab tests or imaging.
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I am 18 years old or older.
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I have had chemotherapy or radiation for my tumor.
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I am willing to have surgery and understand the risks involved.
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I have tumors that haven't been removed or still show on scans.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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I have not taken Avastin in the last 6 months.
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I am under 18 years old.
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I am considered vulnerable due to pregnancy or inability to consent.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 5 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 5 years for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Feasibility of surgical resection by short and long term outcomes
Incidence of adverse events
Secondary study objectives
Neurosurgical morbidity
Overall survival
Progression free survival
+3 more

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups
Experimental Treatment
Group I: Treatment (surgery)Experimental Treatment1 Intervention
Patients undergo surgery as indicated clinically when applicable.

Find a Location

Who is running the clinical trial?

Mayo ClinicLead Sponsor
3,343 Previous Clinical Trials
3,062,309 Total Patients Enrolled
National Cancer Institute (NCI)NIH
13,928 Previous Clinical Trials
41,017,998 Total Patients Enrolled
Terence C BurnsPrincipal InvestigatorMayo Clinic in Rochester
4 Previous Clinical Trials
391 Total Patients Enrolled

Media Library

Brain Surgery Clinical Trial Eligibility Overview. Trial Name: NCT04810871 — N/A
Brain Tumor Research Study Groups: Treatment (surgery)
Brain Tumor Clinical Trial 2023: Brain Surgery Highlights & Side Effects. Trial Name: NCT04810871 — N/A
Brain Surgery 2023 Treatment Timeline for Medical Study. Trial Name: NCT04810871 — N/A
~3 spots leftby Mar 2025
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