Early Brain Surgery for Brain Tumor
Trial Summary
What is the purpose of this trial?
This clinical trial evaluates the side effects and possible benefits of operating on brain tumors prior to the tumor coming back (recurrence). Understanding when surgery is most useful to patients with brain tumors is important. Some patients may undergo chemotherapy or radiation but still have visible tumor remaining after treatment. The purpose of this research is to compare outcomes of those who have surgery after chemotherapy or radiation, but prior to tumor recurrence, to those who have surgery at a different time, or no surgery at all.
Will I have to stop taking my current medications?
The trial information does not specify if you need to stop taking your current medications. However, if you have taken Avastin in the past 6 months, you cannot participate in this trial.
What data supports the effectiveness of the treatment 'Early Brain Surgery for Brain Tumor'?
Is early brain surgery for brain tumors generally safe for humans?
Research on brain surgery, including craniotomy and neurosurgery for brain tumors, shows that while it is a high-risk procedure, efforts are being made to improve safety and reduce complications. Studies have reviewed adverse events and complications, indicating that while risks exist, understanding and managing these risks is a focus in the field.56789
How does early brain surgery for brain tumor differ from other treatments?
Early brain surgery for brain tumors, particularly using awake craniotomy, allows surgeons to perform the procedure while the patient is awake, enabling real-time communication to minimize the risk of damaging critical brain areas. This approach can lead to more precise tumor removal and potentially better outcomes compared to traditional methods where the patient is fully anesthetized.310111213
Eligibility Criteria
This trial is for adults over 18 who've had chemo or radiation for brain tumors but still have some tumor left. They must be willing to undergo surgery, not be pregnant or unable to consent, and can't have had a complete tumor removal before. They should also not qualify for other clinical trials.Inclusion Criteria
Exclusion Criteria
Trial Timeline
Screening
Participants are screened for eligibility to participate in the trial
Surgery
Patients undergo surgery as indicated clinically when applicable
Follow-up
Participants are monitored for safety and effectiveness after surgery
Long-term follow-up
Participants are monitored for long-term outcomes such as local recurrence and overall survival
Treatment Details
Interventions
- Brain Surgery (Procedure)