Right Time Eating and Delayed Time Eating for Colorectal Cancer
(AFT Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores how different eating and drinking habits might affect the risk of developing colorectal cancer. Participants will try various combinations of meal timing and alcohol consumption over several weeks to observe how these habits influence the body's natural rhythms and gut health. It is ideal for individuals who have had advanced tubular adenoma (a type of colon polyp) in the past year and do not have certain health conditions that could interfere with the study. The goal is to better understand how lifestyle choices impact cancer risk, potentially helping to identify individuals at higher risk in the future. As an unphased trial, this study offers a unique opportunity to contribute to groundbreaking research that could lead to improved prevention strategies for colorectal cancer.
Will I have to stop taking my current medications?
The trial does not specify if you must stop all current medications, but you cannot participate if you regularly use medications that affect melatonin, like melatonin supplements, certain anti-nausea drugs, or sleep aids, in the four weeks before the study.
What prior data suggests that these eating patterns and alcohol consumption are safe for participants?
Research shows that meal timing can affect the risk of colorectal cancer. Eating meals during the day might lower this risk, while eating later could increase the chance of developing certain colorectal growths.
Heavy alcohol consumption is a known risk factor for colorectal cancer. The effects of moderate drinking are less clear, but some studies suggest it might not be completely safe.
Adjusting meal times and moderating alcohol intake are generally safe and common lifestyle changes. However, even moderate alcohol consumption carries some health risks.12345Why are researchers excited about this trial?
Researchers are excited about this trial because it explores how the timing of eating and moderate alcohol consumption might influence colorectal cancer outcomes. Unlike standard treatments that focus on medication or surgical interventions, this trial investigates lifestyle changes as a potential factor in cancer management. By examining “right time” eating and “delayed time” eating patterns, both with and without alcohol, the trial aims to uncover whether these daily habits could play a role in cancer prevention or progression. This is particularly intriguing because it suggests a non-invasive approach that could complement existing treatment options.
What evidence suggests that this trial's treatments could be effective for colorectal cancer?
This trial will compare "right-time eating" and "delayed-time eating" with and without alcohol consumption. Research has shown that eating meals at regular times earlier in the day, known as "right-time eating," may help maintain colon health and lower cancer risk. In contrast, eating meals later, called "delayed-time eating," can disrupt the body's natural rhythms and may worsen alcohol's harmful effects on the colon. Some studies suggest that eating at the right times might protect against colon issues related to alcohol. However, research on the effects of eating later continues. Overall, maintaining a regular meal schedule could benefit colon health, especially when combined with limited alcohol intake.678910
Who Is on the Research Team?
Ali Keshavarzian, MD
Principal Investigator
Rush University Medical Center
Are You a Good Fit for This Trial?
This trial is for adults over 21 who've had advanced tubular adenoma in the past year. It's not for those with sleep apnea, alcohol disorders, genetic predispositions to colorectal cancer, inflammatory bowel diseases, or conditions affecting the circadian system like chronic renal failure or night shift work.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Intervention
Participants undergo four different eating and alcohol consumption conditions, each lasting one week, with a wash-out period in between.
Follow-up
Participants are monitored for safety and effectiveness after intervention
What Are the Treatments Tested in This Trial?
Interventions
- Alcohol
- Delayed time eating
- Right time eating
- Sigmoidoscopy
Trial Overview
The study tests how 'right-time' and 'delayed-time' eating patterns combined with alcohol consumption affect susceptibility to colorectal cancer. Participants will try four different conditions involving these variables and undergo sigmoidoscopies and optional circadian assessments.
How Is the Trial Designed?
4
Treatment groups
Experimental Treatment
"Right-time eating" means breakfast before 8am, lunch before 1 pm and dinner before 6pm. Subjects will be asked to stick to this eating schedule for 1 week. Subjects will randomly be assigned to each eating pattern during the study period. Moderate alcohol drinking means 0.3-0.5 g/kg alcohol daily, which will be not more than 2 glasses of wine depending on subject's weight. Alcohol will always be consumed in the evening with food or after food (e.g., dinner). The timing of alcohol consumption will be consistent for each individual. Subjects will be provided with red wine for the 1 alcohol intervention week. The order of conditions will be random.
"Right-time eating" means breakfast before 8am, lunch before 1 pm and dinner before 6pm. Subjects will be asked to stick to this eating schedule for 1 week. Subjects will be asked to not drink alcohol for 1 week. Subjects will randomly be assigned to each eating pattern during the study period.
"Delayed-eating" means eating each meal 3 hours later than the "Right-time eating."Subjects will be asked to stick to this eating schedule for 1 week. Subjects will randomly be assigned to each eating pattern during the study period. Moderate alcohol drinking means 0.3-0.5 g/kg alcohol daily, which will be not more than 2 glasses of wine depending on subject's weight. Alcohol will always be consumed in the evening with food or after food (e.g., dinner). The timing of alcohol consumption will be consistent for each individual. Subjects will be provided with red wine for the 1 alcohol intervention week. The order of conditions will be random.
"Delayed-eating" means eating each meal 3 hours later than the "Right-time eating."Subjects will be asked to stick to this eating schedule for 1 week. Subjects will randomly be assigned to each eating pattern during the study period. Subjects will be asked to not drink alcohol for 1 week.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Rush University Medical Center
Lead Sponsor
Citations
Right Time Eating and Delayed Time Eating for Colorectal ...
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“Right-time eating” means breakfast before 8am ... colorectal cancer. Additionally, the knowledge ... collect follow-up data on you. If follow-up ...
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researchgate.net
researchgate.net/publication/337002396_Abnormal_Eating_Patterns_Cause_Circadian_Disruption_and_Promote_Alcohol-Associated_Colon_CarcinogenesisAbnormal Eating Patterns Cause Circadian Disruption and ...
ileum. 24. Mice were exposed to WTE or right-time eating. (RTE) regimens, either alcohol-treated (RTE þalcohol or. WTE þalcohol) or water-treated (RTE þwater ...
Meta-analysis of 16 studies of the association of alcohol with ...
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