Cancer Screening for Colorectal Cancer

Palo Alto (17 mi)

Overseen byChristine D Berg

Age: 18+

Sex: Any

Travel: May be covered

Time Reimbursement: Varies

Trial Phase: N/A

Waitlist Available

Sponsor: National Cancer Institute (NCI)

No Placebo Group

Trial Summary

What is the purpose of this trial?This clinical trial studies whether screening methods used to diagnose cancer of the prostate, lung, colon, rectum, or ovaries can reduce deaths from these cancers. Screening tests may help doctors find cancer cells early and plan better treatment for colorectal cancer.

Eligibility Criteria

This trial is for men and women aged 55 to 74 who haven't had certain cancer screenings in the past three years. It's not for those with a history of specific cancers, major organ removals, or current cancer treatment (except some skin cancers). Women who've had both ovaries removed could join after October 1996.

Exclusion Criteria

I have had cancer in my colon, rectum, lung, prostate, or PLCO-related cancers.

I am under 55 or over 75 years old.

I have had surgery to remove my entire colon, one lung, or my entire prostate.

I am currently being treated for cancer, not including basal or squamous skin cancer.

I am a male who has had multiple PSA tests in the last 3 years.

Treatment Details

The study tests if sigmoidoscopy (a procedure to look inside the lower part of the large intestine) and a screening questionnaire can help detect colorectal cancer early and reduce death rates from this disease.

2Treatment groups

Active Control

Group I: Colorectal ScreeningActive Control2 Interventions

Participants undergo a colorectal examination with a flexible sigmoidoscope at baseline and year 5. Participants complete a DQX at baseline and DHQ at year 3. An ADU (previously referred to as the PSH questionnaire) is mailed to each participant annually for 13 years to identify all prevalent and incident colorectal cancers as all deaths that occur among both screened and control subjects during the trial.

Group II: ControlActive Control1 Intervention

Participants receive standard medical care. Participants complete a DHQ at baseline.