tDCS + TUS for Opioid Use Disorder
Trial Summary
What is the purpose of this trial?
The purpose of this study is to assess the effects of transcranial Direct Current Stimulation (tDCS) applied in conjunction with Transcranial Ultrasound (TUS) for the treatment of addiction in opiate use disorder with chronic pain. The investigators hypothesize that there will be a decrease in drug use and improved psychosocial assessments with active stimulation, when compared to sham stimulation.
Will I have to stop taking my current medications?
The trial information does not specify if you need to stop taking your current medications. However, if you have recently started on antiepileptic drugs, you may not be eligible to participate.
What data supports the effectiveness of this treatment for opioid use disorder?
Is tDCS safe for humans?
How is the tDCS + TUS treatment for opioid use disorder different from other treatments?
The tDCS + TUS treatment is unique because it uses non-invasive brain stimulation techniques to modulate brain activity, potentially reducing cravings and withdrawal symptoms in opioid use disorder. Unlike traditional drug treatments, this approach directly targets brain regions associated with addiction through electrical currents, offering a novel way to address substance use disorders.12679
Eligibility Criteria
This trial is for adults aged 18-85 with opioid use disorder (OUD) and chronic pain, who have been diagnosed according to DSM-5 criteria. Participants must consent to the study, live locally without relocation plans, and can't be on high doses of methadone. Excluded are pregnant individuals, those with a history of illegal stimulant use or certain neurological disorders, recent brain surgery patients, or those on new antiepileptic drugs.Inclusion Criteria
Exclusion Criteria
Trial Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive transcranial Direct Current Stimulation (tDCS) and Transcranial Ultrasound (TUS) for the treatment of addiction in opiate use disorder with chronic pain
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- Optimization of NIBS for Treatment of Addiction (Non-invasive Brain Stimulation)