Intraoperative Microdialysis for Brain Tumor
Trial Summary
What is the purpose of this trial?
This trial uses a small device during brain surgery to collect fluid samples from patients with brain tumors. The collected fluid is tested to find indicators of the disease. This information may help doctors better diagnose, monitor, and treat brain tumors.
Do I need to stop my current medications for the trial?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
Is intraoperative microdialysis for brain tumor surgery safe?
Intraoperative microdialysis has been used in various neurosurgical procedures to monitor brain metabolism and pH levels, with some patients experiencing stable outcomes and others having complications like hemiparesis (weakness on one side of the body). While it shows potential for monitoring, more experience is needed to fully understand its safety.12345
How is intraoperative cerebral microdialysis different from other treatments for brain tumors?
Intraoperative cerebral microdialysis is unique because it allows real-time sampling of the fluid around brain tumors during surgery, providing direct information about the tumor environment and drug levels, unlike traditional methods that rely on blood or spinal fluid samples. This technique uses a special catheter to collect molecules directly from the tumor area, offering more precise data for treatment decisions.12678
Research Team
Terence C Burns, MD, PhD
Principal Investigator
Mayo Clinic in Rochester
Eligibility Criteria
Adults (18+) with certain brain tumors or epilepsy needing surgery can join. They should be in fair to good health otherwise, as measured by ECOG performance status. Surgery must be planned at Mayo Clinic in Rochester, MN, and participants need to consent to the study.Inclusion Criteria
Exclusion Criteria
Trial Timeline
Screening
Participants are screened for eligibility to participate in the trial
Intraoperative Microdialysis
Patients undergo microdialysis over 30 minutes during standard of care biopsy or resection
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- Intraoperative cerebral microdialysis using M dialysis 107 pump and 71 High cut-off brain microdialysis catheter (Device)
Find a Clinic Near You
Who Is Running the Clinical Trial?
Mayo Clinic
Lead Sponsor
Dr. Gianrico Farrugia
Mayo Clinic
Chief Executive Officer since 2019
MD from University of Malta Medical School
Dr. Richard Afable
Mayo Clinic
Chief Medical Officer
MD from Loyola Stritch School of Medicine
National Institute of Neurological Disorders and Stroke (NINDS)
Collaborator
Jordan Gladman
National Institute of Neurological Disorders and Stroke (NINDS)
Chief Medical Officer
MD from Harvard Medical School
Walter J. Koroshetz
National Institute of Neurological Disorders and Stroke (NINDS)
Chief Executive Officer since 2007
MD from the University of Chicago
National Cancer Institute (NCI)
Collaborator
Dr. Douglas R. Lowy
National Cancer Institute (NCI)
Chief Executive Officer since 2023
MD from New York University School of Medicine
Dr. Monica Bertagnolli
National Cancer Institute (NCI)
Chief Medical Officer since 2022
MD from Harvard Medical School