Neurophysiological Assessments for Chronic Pain and Opioid Risk

Recruiting in Palo Alto (17 mi)

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: The Cleveland Clinic

No Placebo Group

Trial Summary

What is the purpose of this trial?This study is designed to find behavioral and neurophysiological correlates of pain avoidance behavior among chronic pain patients, controlling for risk for opioid use disorder. Further, traits and risk factors that contribute to pain avoidance behavior will be investigated. The knowledge gained will broaden the current understanding of mechanisms involved in pain avoidance behavior in chronic pain patients, and help devise novel interventions.

Eligibility Criteria

This trial is for adults with chronic pain, rating their daily pain ≥5 out of 10 for the past month. They must have CRPS I or II, allodynia, and severe pain that hasn't improved after six months of treatment. Participants need to be willing to undergo brain scans and tests, and have mostly one-sided pain.

Inclusion Criteria

You can have a brain MRI scan.

Willingness to complete behavioral, clinical and neurophysiological measurement procedures

My daily pain level has been 5 or more on a scale of 0 to 10 for the past month.

+6 more

Exclusion Criteria

I have been diagnosed with a condition that causes pain.

My daily pain level has been below 5 for the last month.

I experience pain on both sides of my body.

+6 more

Participant Groups

The study uses EEG/MEG/MRI scans to understand how people with chronic pain try to avoid more pain and how this might relate to the risk of opioid addiction. It looks at behaviors, brain activity patterns, traits, and risk factors linked to avoiding pain.

2Treatment groups

Experimental Treatment

Group I: PatientsExperimental Treatment1 Intervention

Patients with CRPS diagnosis

Group II: ControlsExperimental Treatment1 Intervention

Healthy controls with known Neurological Disorders