Stress Reduction Therapies for Ovarian Cancer
Recruiting in Palo Alto (17 mi)
+8 other locations
Age: 18+
Sex: Female
Travel: May Be Covered
Time Reimbursement: Varies
Trial Phase: Academic
Recruiting
Sponsor: Memorial Sloan Kettering Cancer Center
Must be taking: β-blockers, COX2 inhibitors
Must not be taking: β-blockers, COX inhibitors
Disqualifiers: Autoimmune disease, Active infection, Pregnancy, others
No Placebo Group
Trial Summary
What is the purpose of this trial?This trial tests if propranolol, etodolac, MBRT, and music therapy can reduce stress in patients having major surgeries. These treatments aim to lower anxiety, pain, and promote relaxation. Propranolol has been found to reduce anxiety in various medical settings, including day case surgery.
Will I have to stop taking my current medications?
The trial requires that you do not take any β-blockers or COX inhibitors, as chronic treatment with these medications is an exclusion criterion. If you are currently on these medications, you would need to stop taking them to participate in the trial.
What data supports the effectiveness of the treatment for stress reduction in ovarian cancer patients?
Research shows that music therapy, a component of the treatment, can effectively reduce stress, anxiety, and pain in cancer patients, improving their mood and overall well-being during treatment.
12345Is music therapy safe for humans?
Music therapy is generally considered safe and can be beneficial for various physical, emotional, and psychological needs. It is used as an adjunct therapy in many medical settings and has been shown to help with stress, anxiety, and other symptoms without replacing traditional medical treatments.
46789How does music therapy differ from other treatments for ovarian cancer?
Music therapy is unique because it uses music to help reduce stress, anxiety, and improve mood, which can be particularly beneficial for cancer patients. Unlike traditional medical treatments, it involves active or passive participation in music sessions led by a trained therapist, focusing on emotional and psychological support rather than directly targeting the cancer itself.
1351011Eligibility Criteria
This trial is for adults over 18 with advanced ovarian, fallopian tube, or peritoneal carcinoma who are scheduled for surgery. Participants must understand the study and consent to it. Exclusions include active infections, pregnancy, chronic autoimmune diseases, other clinical trial participation that conflicts with this one, and certain medical conditions like asthma or liver failure.Inclusion Criteria
I understand the study's goals, can follow the rules, and agree to participate.
I am 18 years old or older.
I am scheduled for surgery to examine my abdomen and remove as much cancer as possible.
+3 more
Exclusion Criteria
I am on long-term medication for heart issues or pain that includes β-blockers or COX inhibitors.
I am undergoing a minimally invasive procedure.
I cannot take β-blockers due to certain health conditions like asthma or heart issues.
+6 more
Trial Timeline
Screening
Participants are screened for eligibility to participate in the trial
2-4 weeks
Preoperative Intervention
Participants receive mind-body resilience training/MBRT, music therapy, propranolol, and etodolac before surgery
1 week
1 visit (in-person)
Surgical Procedure
Participants undergo primary debulking surgery (PDS) or interval debulking surgery (IDS)
1 day
1 visit (in-person)
Postoperative Intervention
Participants receive postoperative mind-body resilience training/MBRT, music therapy, propranolol, and etodolac
7 days
Daily visits (in-person or virtual)
Follow-up
Participants are monitored for safety and effectiveness after treatment
21 days
Participant Groups
The PRESERVE study tests if propranolol and etodolac combined with mind-body resilience training and music therapy can reduce stress in patients undergoing surgery for ovarian cancer better than standard care without these interventions.
2Treatment groups
Experimental Treatment
Active Control
Group I: PSRBExperimental Treatment4 Interventions
Participants will receive mind-body resilience training/MBRT, music therapy, propranolol and etodolac pre and post operatively. Postoperative Psychological Interventions may occur between POD 1-7 if needed.
Group II: Standard of CareActive Control1 Intervention
Participants will receive usual care (study interventions not specifically recommended)
Find a Clinic Near You
Research Locations NearbySelect from list below to view details:
Memoral Sloan Kettering Basking Ridge (Limited Protocol Activities)Basking Ridge, NJ
Memoral Sloan Kettering Westchester (Limited Protocol Activities)Harrison, NY
Memorial Sloan Kettering Cancer Center @ Suffolk-Commack (Limited protocol activities)Commack, NY
Memorial Sloan Kettering Bergen (Limited Protocol Activities)Montvale, NJ
More Trial Locations
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Who Is Running the Clinical Trial?
Memorial Sloan Kettering Cancer CenterLead Sponsor
References
Music therapy in supportive cancer care. [2022]The purpose of this paper is to show some aspects of music therapy application in cancer care and to present the integration of music therapy program into a continuous supportive cancer care for inpatients. A cancer diagnosis is one of the most feared and serious life events that causes stress in individuals and families. Cancer disrupts social, physical and emotional well-being and results in a range of emotions, including anger, fear, sadness, guilt, embarrassment and shame. Music therapy is a part of a complementary medicine program in supportive cancer care which accompanies medical treatment. There are many benefits of music therapy for cancer patients-interactive music therapy techniques (instrumental improvisation, singing) as well as receptive music therapy techniques (listening to recorded or live music, music and imaginary) can be used to improve mood, decrease stress, pain, anxiety level and enhance relaxation. Music therapy is an effective form of supporting cancer care for patients during the treatment process. It may be also basic for planning effective programs of rehabilitation to promote wellness, improve physical and emotional well-being and the quality of life.
Guided imagery and music: using the Bonny method to evoke emotion and access the unconscious. [2022]The healing power of music has been recognized since ancient times. The use of music has been documented in diverse cultures worldwide, for ailments ranging from pain and cancer to depression and posttraumati stress disorder. The various models of music therapy are based on different theoretical traditions, including behaviorist, humanist, and psychodynamic approache This article describes the music therapy approach known as the Bonny Method of Guided Imagery and Music (GIM) therapy, reviews its research base, and presents a first-person account of the experience of GIM treatment.
Music therapy: a valuable adjunct in the oncology setting. [2011]Music therapy is the supervised and therapeutic use of music by a credentialed therapist to promote positive clinical outcomes. It can be a valuable form of complementary medicine in the oncology setting to decrease patient stress and anxiety, relieve pain and nausea, provide distraction, alleviate depression, and promote the expression of feelings. The music therapist assesses the patient and consults other members of the multidisciplinary team to create a therapeutic treatment plan. Music therapists design music sessions based on patients' needs and their intended therapeutic goals. Patients can participate actively or passively in individual or group sessions. Only a credentialed music therapist can provide safe and beneficial music therapy interventions.
Music therapy research and applications in pediatric oncology treatment. [2017]Music therapy is a profession which meets multiple physical, social, and psychological needs. Music therapists can facilitate health objectives by reducing the intensity or duration of pain, alleviating anxiety, and decreasing the amount of analgesic medication needed. Rehabilitative objectives can include activities which incorporate exercise, range of motion therapy, or gait training. Reduction of fear, anxiety, stress, or grief are common psychological objectives. Music therapy is particularly effective in promoting social objectives such as increased interaction, verbalization, independence, and cooperation; enhanced relationships with health care personnel and family members; and increased stimulation during long-term hospitalization or isolation. Counseling techniques are often paired with music to achieve emotional objectives such as expression, adjustment, stability, or locus of control. The purpose of this article is to synthesize the extant music/medical research literature and clarify how music therapy can provide a quintessential combination of physical, social, and psychological benefits to enhance the health care of pediatric oncology patients.
Music therapy for mood disturbance during hospitalization for autologous stem cell transplantation: a randomized controlled trial. [2015]High-dose therapy with autologous stem cell transplantation (HDT/ASCT) is a commonly used treatment for hematologic malignancies. The procedure causes significant psychological distress and no interventions have been demonstrated to improve mood in these patients. Music therapy has been shown to improve anxiety in a variety of acute medical settings. In the current study, the authors determined the effects of music therapy compared with standard care on mood during inpatient stays for HDT/ASCT.
[Music therapy and internal medicine]. [2006]Since December 1988 the district hospital of the Oberwallis hosts the 4 year project "Music-Therapy in Internal Medicine" under the scientific guidance of Dr. H. H. Decker-Voigt, director of the Institute of music therapy of the musical academy Hamburg. This therapy can be described as a form of psychotherapy which uses the medium music with its particularities as an adjunct for treatment. The different levels of action of music, a functional and a regressive one and their respective importance for music therapy are described first. An introduction to the two forms of music therapy, the receptive and the active with their respective particularities follows. Indications for music therapy are by large not disease-specific but depend on the assessment of the importance of psychic components in somatic disease. Coping with disease, psychosocial integration and promotion of positive resources or self-healing potential are regarded as indications for music therapy. Music therapy is not indicated when the patient is not motivated or his stay at the hospital is shorter than 2 weeks. We offer a music therapy to all patients in whose illness, according to our evaluation, emotional and psychic factors play an important role and to those patients with functional disorders on whom we would like to learn more by the psychoanalytic possibilities of music therapy. According to our experience music therapy is well suited as an adjunct in many diseases in internal medicine and represents an enrichment of our therapeutic possibilities.
Music therapy for dementia symptoms. [2020]While music/music therapy does not represent a treatment of dementia, its use is based on a possible beneficial effect on symptoms including social, emotional and cognitive skills and for decreasing behavioral problems of individuals with dementias. Thus, there are clear implications for patients' and caregivers' quality of life. However, quantification and documentation of the evidence of this effect is necessary. Professional music therapists are accountable for providing efficient, beneficial treatment. Furthermore, music therapists are responsible for assessing, designing and implementing music therapy treatments, monitoring client progress, and reformulating their practice according to data collected and new advancements in the field. If they wait until sufficient valid, empirical data on all aspects of a disability or music response are available before attempting to design a therapy session, they may well reach retirement age before even one client can be served. On the other hand, promulgating the efficacy of music therapy in general, or of specific music therapy techniques, in the absence of any substantiation other than intuition or tradition borders on professional recklessness.
Integrative Music Therapy: A Healing Intervention. [2019]Music plays a significant role in the lives of individuals across the lifespan. Some healthcare providers may not appreciate music therapy and the positive benefits it can have on the environment, patients, caregivers, and healthcare staff. Integrative Music Therapy (IMT) has proven to be effective in multiple settings, offering therapy for behavioral, emotional, physiological, psychological, and psychosocial needs. IMT, performed by a trained, certified professional (MT-BC), does not seek to replace medication or other procedures, but works synergistically with provided healthcare.
[Regulative music therapy and training as a means for enhancing adaptive potentials and for overcoming fatigue and stress]. [2008]The method of regulative music therapy (RMT) by C. Schwabe is presented-its mechanisms, the caring out procedure, usability and application domains. RMT can help to cope with mental and physical overstrain, resulting in variety of disorders regarding sleep and cardiovascular system; stomach and muscle pains, irritability and lack of balance, anxiety. RMT is based on the learning of specific perception form-efficient observation on: one's own personality, body, functions, thoughts, emotions, and not reasoning. In this way the pathogenic attention narrowing is overwhelmed and the behavior changes which reflect on the general well-being and self-tolerance. The music in RMT has a starting function. RMT is used not only in the case of neurosis therapy, it is successfully applied in the preventive medicine as a training method to cope with over-tension and as means to prevent emotional alienation in every day life.
Interactive Music Therapy on Stress Level Reduction in Women Submitted to IVF/ICSI. Prospective Randomized Study. [2022]To identify the effects of interactive music therapy on stress levels in women undergoing high complexity infertility treatments.
Arts therapies for anxiety, depression, and quality of life in breast cancer patients: a systematic review and meta-analysis. [2023]Background. Breast cancer is one of the most common types of cancer. However, only a few trials assess the effects of arts therapies. Material and Methods. We searched the Cochrane Central Register of Controlled Trials, PubMed, and Google Scholar from their start date to January 2012. We handsearched reference lists and contacted experts. All randomized controlled trials, quasi-randomized trials, and controlled clinical trials of art interventions in breast cancer patients were included. Data were extracted and risk of bias was assessed. Meta-analyses were performed using standardized mean differences. Results. Thirteen trials with a total of 606 patients were included. Arts therapies comprised music therapy interventions, various types of art therapy, and dance/movement therapies. The methodological quality ranged from poor to high quality with the majority scoring 3 of 4 points on the Jadad scale. Results suggest that arts therapies seem to positively affect patients' anxiety (standardized mean difference: -1.10; 95%, confidence interval: -1.40 to -0.80) but not depression or quality of life. No conclusion could be drawn regarding the effects of arts therapy on pain, functional assessment, coping, and mood states. Discussion. Our review indicates that arts interventions may have beneficial effects on anxiety in patients with breast cancer.